SCIENTIFIC AND INFORMATION-ANALYTICAL MAGAZINE

ISSN 1024-6177 (Print), ISSN 2618-9615 (Online)

Medical Radiology and Radiation Safety. 2016. Vol. 61. No. 2. P. 5-19

RADIATION BIOLOGY

A.N. Koterov, L.N. Ushenkova, A.P. Biryukov, A.S. Samoilov

RET/PTC Gene Rearrangements Frequency in Papillary Thyroid Carcinoma Worldwide Depending on Time After Chernobyl Nuclear Power Plant Accident (Pooled-Analysis)

A.I. Burnasyan Federal Medical Biophysical Center of FMBA, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

ABSTRACT

Results of pooled-analysis of primary data in the database formed from molecular epidemiological sources on RET/PTC generearrangements frequency in papillary thyroid carcinoma developed spontaneously and after Chernobyl nuclear power plant accident showed declined chronological trends for RET/PTC1, RET/PTC3 and RET/PTC after the incident separately for cohorts from Europe, USA + Canada and the Asia-Pacific region have been demonstrated. The above trend for RET/PTC3 and RET/PTC in total was similar to trends observed in carcinomas of Chernobyl etiology (Belarus, Russia and Ukraine), although there was no apparent time dependence for RET/PTC1 level in this case. Observed trends could not be connected to any chronological changes in the degree of carcinoma differentiation or age factor for tumor. As chronological changes of RET/PTC frequency in carcinomas in different continents and regions can not be explained by the radiation factor of the Chernobyl accident, it was concluded about the predominant contribution of the ‘human factor’ associated with ‘overestimation’ and ‘overdiagnosis’ of early forms of thyroid tumors in connection with increased vigilance after the Chernobyl accident. Apparently, these factors, along with improvement of instrumental methods at that time, coupled with the ‘aggressive surgery’, took place worldwide resulting in detection of early forms of the occult carcinomas and microcarcinomas. The frequency of RET/PTC in such tumors is higher than in conventional tumors. The frequence of these subjective factors is likely to decrease with time from the date of the Chernobyl accident.

Key words: pooled-analysis, RET/PTC gene rearrangements, papillary thyroid carcinoma, the time after the Chernobyl accident, overestimation

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For citation: Koterov AN, Ushenkova LN, Biryukov AP, Samoilov AS. RET/PTC Gene Rearrangements Frequency in Papillary Thyroid Carcinoma Worldwide Depending on Time After Chernobyl Nuclear Power Plant Accident (Pooled-Analysis). Medical Radiology and Radiation Safety. 2016;61(2):5-19. Russian.

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