SCIENTIFIC AND INFORMATION-ANALYTICAL MAGAZINE

ISSN 1024-6177 (Print), ISSN 2618-9615 (Online)

Medical Radiology and Radiation Safety. 2015. Vol. 60. No. 5. P. 59-73

REVIEW

E.A. Dunaeva1, A.V. Boyko1, L.V. Demidova1, L.Z. Velher2, L.I. Korobkova2, A.U. Korobkova2, O.B. Dubovetskaya1, T.A. Teleous1

Conservative Methods of Prevention and Treatment of Radiation Complications in Patients with Malignant Neoplasms of Female Genital Organs

1. P.A. Herzen Research Oncological Institute, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. A.I. Evdokimov Moscow Stage University of Medicine and Dentistry, Moscow, Russia

CONTENTS

Radiation therapy of malignant tumors of the genitals, even with the use of modern equipment and radiotherapy capabilities, as well as, dosimetry planning leads to the development of pathological changes in the mucosa of the rectum, bladder and vagina in 20-80 % of patients. The main factors influenced on the occurrence and severity of radiation damage are: the value of single and total focal dose, the dose fractionation regimen, method of irradiation (remote, intracavitary, combined), the number of exposures (2, 4, 6 patch reference technique for remote RT), co-morbidities of annexa (rectosigmoid colon, bladder, vagina), radiomodifications (chemotherapy, hyperthermia), surgery on the pelvic organs and the initial state of the organism. In the treatment of local radiation damage generally used approach includes methods of general and local feedback. Among conservative methods of treatment of local radiation injuries physical impact factors, such as low-intensity laser radiation (LLLT) have recently become widely used. Creating optimal combinations of drugs (in the form of ointments, gels, sprays, suppositories, etc.) having a therapeutic effect on wound process are recognized as of promising. The advent of technology aimed (targeted) drug delivery using Kolegel gels suggests a significant impact on the state of tissues within the irradiation zone. Application of these hydrogel materials allowed marking good tolerance, high efficiency in the prevention of radiation reactions (as compared to standard procedures).

Key words: female sexual organs, conservative treatment, radiation complications, radiation rectitis, radiation cystitis, radiation mucousitis, review

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For citation: Dunaeva EA, Boyko AV, Demidova LV, Velher LZ, Korobkova LI, Korobkova AU, Dubovetskaya OB, Teleous TA. Conservative Methods of Prevention and Treatment of Radiation Complications in Patients with Malignant Neoplasms of Female Genital Organs. Medical Radiology and Radiation Safety. 2015;60(5):59-73. Russian.

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