Medical Radiology and Radiation Safety. 2015. Vol. 60. No. 3. P. 65-78

REVIEW

V.S. Kalistratova, I.K. Belyaev, E.S. Zhorova, I.M. Parfenova, G.S. Tischenko

Prophylaxis of Radiation and Chemical Carcinogenesis Using Vitamin A and Its Precursor Beta-Carotene (Experimental and Clinical Studies)

A.I. Burnasyan Federal Medical Biophysical Center of FMBA, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

ABSTRACT

Objective: To summarize our own and literature data on the anti-cancer effect of carotenoids obtained in experiments on laboratory animals and clinical studies.

Content: The mechanism of the antitumor effect of vitamin A and beta-carotene, prevention and treatment of chemical and radiation carcinogenesis, long-term consequences for external whole-body irradiation and incorporation of radionuclides (¹³⁷Cs, HTO, ¹³¹I, ²³⁸Pu, ⁹⁰Sr).

Conclusions: It was found that experimental and clinical positive antitumor effects when used carotenoids in the case of chemical and radiation carcinogenesis (increased life expectancy, the latent period and the incidence of some types of tumors) require additional research.

Key words: carcinogenesis, prevention, radiation, chemical factor, laboratory animals, experimental studies, clinical studies, retinol, beta-carotene

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For citation: Kalistratova VS, Belyaev IK, Zhorova ES, Parfenova IM, Tischenko GS. Prophylaxis of Radiation and Chemical Carcinogenesis Using Vitamin A and It`s Precursor Beta-Carotene (Experimental and Clinical Studies). Medical Radiology and Radiation Safety. 2015;60(3):65-78. Russian.

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