Medical Radiology and Radiation Safety. 2015. Vol. 60. No. 1. P. 39-44

RADIATION THERAPY

G.S. Zhamgaryan, L.I. Musabaeva, V.A. Lisin, Yu.I. Tyukalov

Combined Modality Treatment Including Intraoperative Electron and External Beam Radiation Therapies for Soft Tissue Sarcomas

Tomsk Cancer Research Institute, Tomsk, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

ABSTRACT

Purpose: To study the efficiency of the combined modality treatment including intraoperative radiation therapy (IORT) and external radiotherapy for patients with soft tissue sarcomas.

Material and methods: Between 1991 and 2011, a total of 115 patients with soft tissue sarcomas of the trunk and extremities received combined modality IORT and external beam radiation therapy. There were 44 (38 %), male and 71 female (62 %) patients aged from 15 to 75 years (median age 47.6 ± 2.5 years). Primary sarcomas were diagnosed in 79 (69 %) patients and recurrent sarcomas in 36 (31 %). The study included patients with locally advanced stage II-III soft tissue sarcomas and most of them (52 %) had stage III disease.

Results: Acute and late radiation-induced damages were observed only in patients who underwent surgery with 20 Gy IORT. No radiation-induced complications were found in groups I and II. In these groups of patients who received the total radiation dose of 60-65 Gy, the 2-year disease-free survival rates were 76.2 ± 7.5 % and 76.0 ± 11.3 %, respectively.

Key words: combined modality treatment, soft tissue sarcomas, intraoperative radiation therapy, external beam radiotherapy

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For citation: Galstyan IA, Nadejina NM, Levadnaya MG, Aksenenko AV. Ulcer-Cancer of the Skin as an Outcome of Local Radiation Injury. Medical Radiology and Radiation Safety. 2015;60(1):39-44. Russian.

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