Medical Radiology and Radiation Safety. 2014. Vol. 59. No. 2. P. 47-53
NUCLEAR MEDICINE
G.E. Kodina, V.N. Korsunsky, O.E. Klementyeva, A.O. Malysheva, M.V. Zhukova, N.A. Taratonenkova
Preliminary Biological Evaluation of 188Re-Sn Suspension as Promissing Radiopharmaceutical for Radiosynovectomy
Burnasyan Federal Medical Biophysical Center of FMBA, Moscow, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
CONTENT
Purpose: To study the biological behavior of Rhenium-188 suspension as potential radiopharmaceutical for radiosynovectomy on experimental model of joint pathology.
Material and methods: The dynamic behavior of 188Re-Sn suspension was studied in rats with experimental acute aseptic synovitis of knee joint by direct radiometry. The biological behavior of radiopharmaceutical with SPECT/CT was carried out on rabbits with experimental acute aseptic synovitis of knee joint.
Results: We successfully synthesized 188Re-Sn suspension, which can be prepared in the special radiopharmaceutical departments and supplied in clinics according to their demand. This suspension is stable more than 3 days after its preparation. About 90 % of particles in the synthesized suspension were of lower than 9.3 μm. It was found that 188Re-Sn suspension was fixed in knee joint during 72 h post intraarticular injection in rats without redistribution. The SPECT/CT results confirmed the absence of radiopharmaceutical leakage from the injection site. Synthesized suspension could be prospective means for radiosynovectomy.
Key words: rhenium-188, suspension, acute synovitis, experimental model, radiosynovectomy