Medical Radiology and Radiation Safety. 2020. Vol. 65. No. 2. P. 21–26

R.M. Takhauov^1,2, D.S. Isubakova¹, E.V. Bronikovskaya¹, O.S. Tsymbal¹, M.V.  Khalyuzova¹, L.R. Takhauova², A.B. Karpov^1,2, N.V. Litviakov^1,3, I.V. Milto^1,2

The Bank of Biological Samples by Seversk Biophysical Research Center

¹ Seversk Biophysical Research Center, Seversk, Russia
² Siberian State Medical University, Tomsk, Russia
³ Tomsk Cancer Research Institute, Tomsk, Russia
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Abstract

Purpose: Description of the collection, structure and development dynamics during the period from 2015 to 2019 of the biological material bank of the Seversk Biophysical Research Center, as well as research works carried out using biological material from its collection.

Material and methods: The collection of bank of biological material includes the following types of biological material: venous blood, genomic DNA of white blood cells, cytogenetic suspensions of blood lymphocytes, surgical, biopsy and autopsy material. Biological material was obtained from people exposed to chronic radiation exposure: employees of the nuclear industry and the population permanently residing in the territory located in the area of the nuclear industry.

Results: At present, the collection of the biological material bank contains more than 21,000 samples of biological material obtained from more than 8,000 donors. The collection of bank of biological material is represented by 4 main blocks: biological material of conditionally healthy employees of company of the nuclear industry (Siberian Chemical Combine); biological material of conditionally healthy people permanently residing in the territory located in the area of the nuclear industry enterprise (Seversk); biological material of patients (workers of the Siberian Chemical Combine and residents of Seversk) with malignant neoplasms and biological material of patients (workers of the Siberian Chemical Combine and residents of Seversk) with acute myocardial infarction. In the collection of bank of biological material, the proportion of samples of biological material of relatively healthy workers of the Siberian Chemical Combine is 33 %, residents of Seversk — 40.8 %, patients with malignant neoplasms — 22.2 %, patients with acute myocardial infarction — 4 %.

Conclusion: Biological material bank Seversk Biophysical Research Center is unique collection of biological material samples of healthy people and patients with socially significant diseases. A feature of the biological material of the biological material bank is that it is obtained from people who have been exposed to chronic low-intensity radiation exposure and can be used to evaluate its radiogenic effects.

Key words: bank of biological material, ionizing radiation, chromosomal aberration, malignant neoplasms, acute myocardial infarction

For citation: Takhauov RM, Isubakova DS, Bronikovskaya EV, Tsymbal OS, Khalyuzova MV, Takhauova LR, et al. The Bank of Biological Samples by Seversk Biophysical Research Center. Medical Radiology and Radiation Safety. 2020;65(2):21-6. (In Russ.).

DOI: 10.12737/1024-6177-2020-65-2-21-26

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Conflict of interest. The authors declare no conflict of interest.

Financing. The study had no sponsorship.

Contribution. Article was prepared with equal participation of the authors.

Article received: 31.10.2019.

Accepted for publication: 12.03.2020.