Medical Radiology and Radiation Safety. 2020. Vol. 65. No. 2. P. 82–86

A.D. Ryzhkov¹, A.S. Krylov¹, A.B. Bludov¹, A.V. Kuzin², S.M. Kaspshik¹, M.B. Dolgushin¹

Evaluation of the SPECT/CT Method in the Diagnosis of Alkaptonuric Ochronosis. Clinical Case

¹ N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia
² Russian Medical Academy of Continuous Professional Education, Moscow, Russia

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Abstract

Purpose: Is to demonstrate functional and structural changes in the musculoskeletal system of the patient with alkaptonuric ochronosis using bone scan and hybrid imaging consisting of single-photon emission computed tomography (SPECT) and X-ray transmission computed tomography (CT) scan (SPECT/CT).

Material and methods: A clinical case report of patient with alkaptonuric ochronosis, examined with bone scan and SPECT/CT.

Results: In this article we show a clinical case with the picture of mineral metabolism disorder and severe degenerative changes of musculoskeletal system in patient with alkaptonuric ochronosis (a genetically determined disease), caused by metabolic disorders of tyrosine. We used hybrid SPECT/CT method for evaluation of this disease.

Conclusion: SPECT/CT method demonstrated structural and metabolic changes. This method allowed us to reveal the specific changes in cases of alkaptonuric ochronosis, but also it shows the possibility of using radionuclide methods in solving non-standard situations, while this method has not previously been applied.

Key words: alkaptonuria, ochronosis, bone scan, SPECT/CT

For citation: Ryzhkov AD, Krylov AS, Bludov AB, Kuzin AV, Kaspshik SM, Dolgushin MB. Evaluation of the SPECT/CT Method in the Diagnosis of Alkaptonuric Ochronosis. Clinical Case. Medical Radiology and Radiation Safety. 2020;65(2):82-6. (In Russ.).

DOI: 10.12737/1024-6177-2020-65-2-82-86

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PDF (RUS) Full-text article (in Russian)

ORCID authors’

Ryzhkov A.D., http://orcid.org/0000-0002-9571-801X
Krylov A.S., http://orcid.org/0000-0002-8476-7879
Bludov A.B., https://orcid.org/0000-0002-0970-6144
Kuzin A.V., http://orcid.org/0000-0002-1262-932Х
Kaspshik S.M., http://orcid.org/0000-0002-1384-9551
Dolguyshin M.B., http://orcid.org/0000-0003-3930-5998

Conflict of interest. The authors declare no conflict of interest.

Informed consent. All patients signed an informed consent to participate in the study.

Financing. The study had no sponsorship.

Contribution. Article was prepared with equal participation of the authors.

Article received: 21.01.2020

Accepted for publication: 12.03.2020.