Medical Radiology and Radiation Safety. 2019. Vol. 64. No. 3. P. 40–45

DOI: 10.12737/article_5cf232752e83d4.66034976

F.S. Torubarov, M.V. Kuleshovа, S.N. Lukyanova, Z.F. Zvereva, A.S. Samoylov

Spectral Correlation Analysis of EEG of Liquidators of the Chernobyl Accident with Neurological Disorders

A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

F.S. Torubarov – Head of Lab., Dr. Sci. Med., Prof.;
M.V. Kuleshova – Doctor-Neurologist, PhD. Med.;
S.N. Lukyanova – Chef Researcher, Dr. Sci. Biol., Prof.;
Z.F. Zvereva – Senior Researcher, Dr. Sci. Med.;
A.S. Samoylov – Director General, Dr. Sci. Med., Prof. RAS;

Abstract

Purpose: Comparative analysis of spectral correlation characteristics of EEG from liquidators of the Chernobyl accident and persons group, with neurological disorders.

Material and methods: A study carried out with the participation of 141 of the liquidator of the Chernobyl accident and 84 people group. Ionizing effects could be subject only to the liquidators. The average radiation dose in a group of liquidators was 110 ± 14 mSv. Groups were matched on age and employment. All persons have passed clinical neurological and electrophysiological examination. The focus of the article given that spectral and correlation analysis of EEG.

Results: Clinical examination made it possible to diagnose neurological disorders in both groups as: vegetovascular dystonia, neurocirculatory dystonia, dyscirculatory encephalopathy of different etiology. Their number and extent dominated statistically in a group of liquidators of the Chernobyl accident. It is important to note that increasing the frequency of their manifestations depending on the liquidators received radiation doses have not been identified. However, the disorder is diagnosed more often in the psychoemotional sphere among liquidators, than in the group mapping (61.7 % and 29.7 %, respectively). The analysis reveals statistically significant differences in EEG spectra in the presence of specified diagnoses compared with known characteristic of norms. Spectral and correlation analysis of EEG complements these data, demonstrating the existence of correlative considered diagnoses and significant differences between groups of liquidators and mappings. Liquidators increased delta-range observed in the authentically greater degree (as compared to a matched group) and combined with a significant reduction in the alpha-frequency index. The observed changes among liquidators are functional and non-specific in nature. Picture of the totality of the observed changes is not specific. It is regarded as one of the non-pathogenic mechanisms of development of the asthenic symptoms of different etiology.

Conclusions: In the group of liquidators revealed a significant increase in the quantity and the degree of neurological disorders. In the spectrum of EEG liquidators reliably amplifies the index delta-activity and decreases the severity of alpha range compared to a mappings group. It is important that these changes are accompanied by a weakening of the correlations between brain structures and disruption EEG rest.

Key words: liquidators of the Chernobyl NPP accident, group comparison, clinical neurological examination, spectral and correlation analysis of EEG, significant differences

REFERENCES

1. Torubarov FS, Blagovechenscaya VV, Cheselin PV, Nikolaev MP. J. Neuropathology and Psychiatry.1989;89(2):48-52. (Russian).
2. Kryzhanivskaya LA. The Chernobyl catastrophe and biomedical rehabilitation. Sat. Conference Materials. Minsk, 1992:50-2. (Russian).
3. Neagu AI, Noshenko AG, Loganovsky KN. J. Neuropathology and Psychiatry. 1992;92(4):72-7. (Russian).
4. Neagu AI. Distant neuropsychiatric effects of the Chernobyl accident. Abstracts of Int. Conf. Actual Problems of Forecasting and Mental Health Violations after a Nuclear Holocaust. 1995;95-101. (Russian).
5. Kuleshova MV. Clinical EEG-study of the consequences of the accident Chernobyl exposed to low doses of ionizing radiation. Moscow: Autoref. PhD. Med. 1998. 18 p. (Russian).
6. Kuleshova MV, Torubarov F.S. Frequency of neurological disorders in persons who took part in liquidation of consequences of the Chernobyl accident, depending on the dose and time of work load. Abstracts. Moscow, III All-Russian Congress of Radiobiologists. 1997. (Russian).
7. Kuleshova MV, Torubarov FS. neurological disorders, structure, particularly the development of pathology in persons who took part in liquidation of consequences of the Chernobyl accident. Abstracts. Moscow, III All-Russian Congress of Radiobiologists. 1997. (Russian).
8. Zhermunskaja EA. Functional interdependence of large hemispheres of the human brain. Leningrad: Science, 1989. 52 p. (Russian).
9. Zhermunskaja EA. Clinical electroencephalography (digits, bar graph, illustration). Moscow: Veta-print. 1993.47 p. (Russian).
10. Kalyuzhny LV, Zacharova IN. EEG data about the interaction of visual cortex, hippocampus and hypothalamus, midbrain reticular formation in the processes of education temporary connection. In: Physiology and Pathology of Limbiko-Reticular System. Ed. P.K. Anokhin, A.M. Wein. Moscow. Nauka, 1971. P. 32-5. (Russian).
11. Wayn AM, Solovyeva AD, Kolosova OA. Vegetovascular Dystonia. Moscow. Medicine, 1981. 318 p. (Russian).
12. Swiderscaya NE. Synchronous Electrical Brain Activity and Mental Processes. Moscow. Science, 1987. 155 p. (Russian).
13. Iljuchenok Ru, Shurgaia AM, Lukyanenko FYa, et al. Mapping of the cortex-subcortex- interaction in the syndrome of asthenic neurosis. J Top Nerv Activity. 1992;(42):911-8. (Russian).
14. Nerobkova L, Tkachenko SB. Clinical Electroencephalography. Moscow. 2016. 200 p. (Russian).
15. Reticular Formation of the Brain. Eds. Jasper GG, Proctor LD, Knighton RS. Moscow. Medicine, 1962. 663 p. (Russian).
16. Vinogradova OS. Hippocampus and Memory. Moscow. Science, 1975. 332 p. (Russian).

For citation: Torubarov FS, Kuleshovа MV, Lukyanova SN, Zvereva ZF, Samoylov AS. Spectral Correlation Analysis of EEG-Liquidators of the Chernobyl accident with Neurological Disorders. Medical Radiology and Radiation Safety. 2019;64(3):40-5. (Russian).

DOI: 10.12737/article_5cf232752e83d4.66034976

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