JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
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Medical Radiology and Radiation Safety. 2026. Vol. 71. № 4
DOI:10.33266/1024-6177-2026-71-4-85-91
S.S. Sokolnikova
ASSESSMENT OF THE INFLUENCE OF RADIATION AND CHEMICAL FACTORS ON THE STATE OF THE GASTRIC MUCOSA IN THE WORKERS OF RADIATION-HAZARDOUS PRODUCTION FACILITIES
Southern Urals Research and Clinical Center for Medical Biophysics, Ozyorsk, Russia
Contact person: S.S. Sokolnikova, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To assess the effect of occupational hazards on the state of the gastric mucosa in the workers of the radiochemical plant of the Mayak Production Association (PA).
Material and methods: Current study includes 62 workers of the Mayak PA radiochemical plant, with a mean age at the date of investigation of 52.7±1.0 years, who were in constant contact with occupational hazards (ionizing radiation and chemical toxins). A laboratory study was performed using GastroPanel test-systems produced by BIOHIT OYJ (Finland). Analysis of the data obtained was carried out using Microsoft Excel software.
Results: Pathological changes in the gastric mucosa identified using a serological method were found in 84% of the group members, for 34% these changes were diagnosed for the first time. The prevalence of Helicobacter pylori infection in the study group (82%) corresponded to the rates for this age group in the Ural region. The incidence of non-atrophic pathology among the workers in the study group (64.5%) was not higher than the rates in the comparison group 9 the workers of city organizations not exposed to occupational hazards). The incidence of pre-cancer stomach diseases (atrophic gastritis) at the radiochemical plant (19.3%) was 4 times higher than in the comparison group (4.8%) (OR 4.8; 95%CI 1.8‒12.8). The overall frequency of gastric pathologies in the group with external exposure doses > 100 mSv was statistically significantly 1.5 times higher compared to the group with exposure doses ≤ 100 mSv (p=0.023).
Conclusion: We have demonstrated that serological method is sufficiently effective to diagnose pre-carcinogenic gastropathology even with no clinical symptoms. The increase of frequency of the gastric mucosa pathology in persons with occupational contact to industrial chemical hazards: increased frequency of gastropathology in workers contacting to inorganic compounds or mixture of inorganic/organic compounds. An increased frequency of gastropathology in workers with cumulative doses of external γ-exposure exceeding 100 mSv had also been demonstrated. The data obtained suggest that differences in the incidence of gastropathology may be related to the impact of occupational risk factors. Due to their combined influence, it is impossible to link changes in the incidence of gastropathology in workers to the impact of a single occupational factor.
Keywords: radiation-hazardous production facilities, personnel, chemical hazards, ionizing radiation, gastric pathology, serological diagnostics
For citation: Sokolnikova SS. Assessment of the Influence of Radiation and Chemical Factors on the State of the Gastric Mucosa in the Workers of Radiation-Hazardous Production Facilities. Medical Radiology and Radiation Safety. 2026;71(4):85–91. DOI:10.33266/1024-6177-2026-71-4-85-91
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PDF (RUS) Full-text article (in Russian)
Conflict of interest.The authors declare no conflict of interest.
Financing. The work was carried out within the framework of the federal target budget.
Contribution. Sokolnikova S.S.: study conception and design, data collection and analysis, manuscript preparation.
Article received: 20.03.2026. Accepted for publication: 25.04.2026.