НАУЧНЫЙ И ИНФОРМАЦИОННО-АНАЛИТИЧЕСКИЙ ЖУРНАЛ

ISSN 1024-6177 (Print), ISSN 2618-9615 (Online)

Медицинская радиология и радиационная безопасность. 2018. Том 63. № 3. С. 52-67

ОБЗОР

DOI: 10.12737/article_5b179d60437d54.24079640

О.К. Курпешев1, J. van der Zee2

АНАЛИЗ РЕЗУЛЬТАТОВ РАНДОМИЗИРОВАННЫХ ИССЛЕДОВАНИЙ ПО ГИПЕРТЕРМИИ В ОНКОЛОГИИ

1. Медицинский радиологический научный центр имени А.Ф. Цыба, Обнинск, e-mail: Этот адрес электронной почты защищен от спам-ботов. У вас должен быть включен JavaScript для просмотра. ; 2. Онкологический институт Эразмусского медицинского центра, Роттердам, Нидерланды

О.К. Курпешев – зав. отд., д.м.н., член Европейского общества по гипертермической онкологии (ESHO); Я. ван дер Зий – Ph.D., MD, член Европейского общества терапевтической радиологии и онкологии (ESTRO) и Европейского общества по гипертермической онкологии (ESHO)

Реферат

В обзоре представлен анализ результатов III фазы рандомизированных исследований комбинированного и комплексного лечения онкологических больных с использованием гипертермии (ГТ). Анализ показал, что ГТ в большинстве случаев значимо улучшает результаты лучевой (ЛТ), химио (ХТ)- и химиолучевой терапии (ХЛТ) больных с местнораспространенными, рецидивными и метастатическими формами опухолей, а у инкурабельных больных достигается паллиативный эффект. Основными причинами отсутствия эффекта от локорегионарной ГТ (ЛРГТ) являются низкие температурно-экспозиционные режимы нагревания (< 40 °C, < 60 мин), вследствие несовершенства методики, неправильного выбора гипертермической установки, типа аппликатора, частоты электромагнитного (ЭМ) излучения. Изучено влияние ГТ на токсические эффекты лучевой и химиолучевой терапии на нормальные ткани. Представлен экономический эффект от использования метода. В связи с различными принципами работы гипертермических аппаратов, общего стандарта проведения ГТ у онкологических больных не существует, для каждой установки и локализации опухоли он должен разрабатываться индивидуально.

Ключевые слова: гипертермия, рандомизация, лучевая терапия, химиотерапия, термолучевая терапия, термохимиотерапия, термохимиолучевая терапия

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Для цитирования: Курпешев О.К., van der Zee J. Анализ результатов рандомизированных исследований по гипертермии в онкологии // Медицинская радиология и радиационная безопасность. 2018. Т. 63. № 3. С. 52-67. DOI: 10.12737/article_5b179d60437d54.24079640

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