Medical Radiology and Radiation Safety. 2022. Vol. 67. № 1
Influence of Drinking Water Quality
in the Course of Radiation Damage Following Fractionated Irradiation
O.V. Nikitenko1,2, I.E. Andrianova1, T.M. Bychkova1,2,
N.M. Stavrakova1, I.M. Parfenova1, T.A. Karaulova1,
A.V. Gordeev1, A.A. Ivanov1,2,3
1A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia
2Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia
3Joint Institute for Nuclear Research, Dubna, Russia
Contact person: Nikitenko Olga Vasilievna, Этот адрес электронной почты защищен от спам-ботов. У вас должен быть включен JavaScript для просмотра.
ABSTRACT
Purpose: Assessment of the role of various factors in the formation of radioresistance is an important section of radiobiology, radiation medicine, including radiation therapy for hematological oncological diseases. The quality of drinking water, as it turned out, can significantly affect the radio resistance. Against the background of studying the antiradiation properties of various types of water, differing in mineral and isotopic composition, the problem of the influence of tap water on the course of radiation injury remained underestimated. This circumstance determined the purpose of the work: to compare the effectiveness of the effect of fractionated total X-ray irradiation in lethal doses, simulating total therapeutic irradiation of oncohematological patients, when consuming tap water and highly purified artificially mineralized tap water in an experiment on mice.
Materials and Methods: Female ICR (CD-1) mice were irradiated with moderately lethal doses of fractionated (daily 4 × 2.2 Gy
and 4 × 2.3 Gy) X-ray irradiation. After exposure, half of the mice received tap water as drinking water, and the other half received artificially mineralized drinking water.
Results: Keeping animals on tap water statistically significantly reduced the survival rate of mice under fractionated irradiation (χ2 = 3.88, p <0.05, log-rank test p = 0.049) compared with animals receiving artificially mineralized distilled water. In addition, in the group of mice that received tap water, an increase in the rate of death of mice and a lower safety of the group weight of animals during the development of acute radiation injury were noted.
Conclusion: Tap water, used as drinking water, increases the damaging effect of radiation with fractionated X-ray irradiation of mice.
Keywords: X-ray exposure, tap water, artificially mineralized distilled water, survival, mortality, mouse
For citation: Nikitenko OV, Andrianova IE, Bychkova TM, Stavrakova NM, Parfenova IM, Karaulova TA, Gordeev AV, Ivanov AA. Influence of Drinking Water Quality in the Course of Radiation Damage Following Fractionated Irradiation. Medical Radiology and Radiation Safety. 2022;67(1):5-10. (In Russian)
DOI: 10.12737/1024-6177-2022-67-1-5-10
References
1. Yagunov A.S., Reeves G.I., Tokalov S.V., Chukhlovin A.B., Afanassiev B.V. Animal Studies of Residual Hematopoietic and Immune System Injury from Low Dose/Low Dose Rate Radiation and Heavy Metals. Bethesda, MD, Armed Forces Radiobiology Research Institute, 1998. DOI: 10.13140/2.1.3584.0007.
2. Carpenter D.O., Bushkin-Bedient S. Exposure to Chemicals and Radiation During Childhood and Risk for Cancer Later in Life. J. Adolesc Health. 2013;52;5:21-29. doi:10.1016/j.jadohealth.2013.01.027.
3. Vacek A., Sikulová J., Bartonícková A. Radiation Resistance in Mice Increased Following Chronic Application of Li2CO3. Acta Radiol. Oncol. 1982;21;5:325-330. doi:10.3109/02841868209134023.
4. Chlorinated Drinking-Water; Chlorination By-Products; Some Other Halogenated Compounds; Cobalt and Cobalt Compounds. IARC Monogr Eval Carcinog Risks Hum. International Agency for Research on Cancer (IARC) Working Group. Lyon, 1991;52:45-399.
5. Melkova K.N., Gorbunova N.V., CHernyavskaya T.Z., Baranov A.YE., Pushkareva S.G., Frolov G.P., et. al. Total Body Irradiation Conditioning for Bone Marrow Transplantation. Klinicheskaya onkogematologiya. Fundamentalnyye issledovaniya i klinicheskaya praktika = Clinical Oncohematology. Basic Research and Clinical Practice. 2012;5;2:96-114 (In Russ.).
6. Sanitary and Epidemiological Rules and Regulations SanPiN 2.1.4.1074-01 Drinking Water. Hygienic Requirements for Water Quality of Centralized Drinking Water Supply Systems. Quality Control. Hygienic Requirements for Ensuring the Safety of Hot Water Supply Systems (In Russ.).
7. Kaplan E.L., Meier P. Non-Parametric Estimation from Incomplete Observations. J. Am. Stat. Assoc. 1958;53;282:457–481.
8. Sacher G.A. On the Statistical Nature of Mortality, with Especial Reference to Chronic Radiation Mortality. Radiology. 1956;67;2:250-258. doi: 10.1148/67.2.250.
9. International Guiding Principles for Biomedical Research Involving Animals. CIOMS. Geneva, 1985.
10. Guidelines for Drinking Water Quality. 4th Edition. WHO Library Cataloging in Publication Data. 2011. P. 584.
11. Van Trigt R. Lazer spectrometry for stable isotope analysis of water // Biomedical and paleoclimatological applications. Groningen, University library groningen, 2002. P. 192
12. Rakhmanin Yu.A. Biophysics of Water: Quantum Nonlocality in Water Treatment Technologies, the Regulatory Role of Associated Water in Cellular Metabolism, Regulation of Bioenergetic Activity of Drinking Water. Ed. Rakhmanin Yu.A., Stekhin A.A., Yakovleva G.V. Moscow, URSS Publ., 2016. 346 p. (In Russ.).
13. Ivanov A.A., Andrianova I.E., Mal'tsev V.N., Shalnova G.A., Stavrakova N.M., Bulynina T.M., et al. The Impact of Drinking Water of Various Quality on Intact and Irradiated Mice. Gigiyena i Sanitariya = Hygiene and Sanitation. 2017;96;9:854-860. DOI: 10.18821/0016-9900-2017-96-9-854-860 (In Russ.).
14. Laissue J.A., Altermatt H.J., Bally E., Gebbers J.O. Protection of Mice from Whole Body Gamma Irradiation by Deuteration of Drinking Water: Hematologic Findings. Exp. Hematol. 1987;15;2:177-180.
15. Ivanov A.A., Ushakov I.B., Kulikova Ye.I., Kryuchkova D.M., Severyukhin Yu.S., Vorozhtsova S.V., Abrosimova A.N., Gayevskiy V.A., Sinyak Yu.Ye., Grigoryev A.I. Light-Isotope Water as a Therapeutic Agent for Acute Radiation Disease. Aviakosmicheskaya i Ekologicheskaya Meditsina = Aerospace and Environmental Medicine. 2013;47;5:40-44 (In Russ.).
16. Abrosimova A.N., Rakov D.V., Sinyak Yu.E. Effect of "Light Water" on the Development of Lens Opacity in Mice after Repeated γ-Irradiation at Low Doses. Aviakosmicheskaya i Ekologicheskaya Meditsina = Aerospace and Environmental Medicine. 2009;3;2:29-32 (In Russ.).
17. Kulikova Ye.I., Kryuchkova D.M., Severyukhin Yu.S., Gayevskiy V.N., Ivanov A.A Radiomodifying Properties of Deuterium-Depleted Water with Poor Content of Heavier Isotopes of Oxygen. Aviakosmicheskaya i Ekologicheskaya Meditsina = Aerospace and Environmental Medicine. 2012;46;6:45-50 (In Russ.).
18. Kryuchkova D.M., Andrianova I.Ye., Kovalenko M.A., et al. Effect of a Mineral-Organic Complex on Mice Radioresistance. Aviakosmicheskaya i Ekologicheskaya Meditsina = Aerospace and Environmental Medicine. 2013;47;5:37-40 (In Russ.).
19. Cantor K.P., Hoover R., Hartge P., et al. Bladder Cancer, Drinking Water Source, and Tap Water Consumption: a Case-Control Study. J. Natl. Cancer Inst. 1987;79;6:1269-1279.
20. Ishidate M.Jr., Sofuni T., Yoshikawa K., Hayashi M., et al. Primary Mutagenicity Screening of Food Additives Currently Used in Japan. Food and Chemical Toxicology 1984;22;8:623-636. doi.org/10.1016/0278-6915(84)90271-0.
21. Eltahawy N.A., Sarhan O.M., Hammad A.S., et al. Effects of Combined Exposure to Aluminum Chloride and γ-Radiation on Histological and Ultrastructure of Intestinal Paneth Cells. Radiat. Res. Appl. Sci. 2016;9:400-408. doi.org/10.1016/j.jrras.2016.05.007.
PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 12.11.2021.
Accepted for publication: 05.12.2021