JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
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Medical Radiology and Radiation Safety. 2024. Vol. 69. № 6
DOI:10.33266/1024-6177-2024-69-6-87-93
G.G. Shimchuk, A.V. Skobliakov, A.A. Golubev, A.V. Kantsyrev, Gr.G. Shimchuk
Assessment of the Possibility of Verification of Proton Dose Distributions by the Method of Induced Positron Activity in Human Tissue
National Research Center “Kurchatov Institute”
Contact person: G.G. Shimchuk, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
A computational assessment was made of the possibility of verifying dose distributions during proton radiation therapy using PET imaging of positron activity in human tissues, which was formed as a result of proton irradiation. To compare the dose distribution of a particle energy-modulated proton beam with a diameter of 10 mm with an initial particle energy of 100 MeV, ensuring uniform irradiation of the target in a 13 mm zone (at the level of 90 % of the radiation dose) at the end of the particle path, with a map of induced activity from the radionuclides 11C, 13N and 15O, numerical calculations were performed in a Monte–Carlo code using the Geant4 simulation program. In the modeling process, a volume with dimensions of 50 × 50 × 100 mm was used, simulating soft tissues of the human body with a density of 1 g/cm3, consisting of hydrogen atoms (62 %), carbon (12 %), oxygen (24 %) and nitrogen (1.1 %). The cross sections for the formation of radionuclides 11C, 13N and 15O in the reactions 12C(p, pn)11C, 14N(p, α)11C, 16O(p, αpn)11C, 14N(p, pn)13N, 16O(p, α)13N, 16O(p, pn)15O have been calculated, which were used to calculate the distributions of positron activity in the irradiated volume. Taking into account the short half-lives of the radionuclides under consideration (primarily oxygen-15), calculations of isoactivities and depth distributions of accumulated radioactivities were performed for various time intervals after irradiation.
The performed computational modeling of the distributions of activities of radionuclides 11C, 13N and 15O during the passage of a modulated proton beam, taking into account the decay of produced radionuclides after irradiation, shows that by recording for 15 minutes the induced activity of PET radionuclides 2 minutes after irradiation, it is possible to obtain data on the compliance of the planned and irradiation of tumors performed during proton therapy. However, small levels of generated activity (at a level of 2 Gy for finely fractionated irradiations) require a device with high efficiency in recording annihilation radiation and high spatial resolution at the level of 1.5–2.0 mm.
Key words: proton irradiation, radionuclides, induced activity, PET, dose fields, verification
For citation: Shimchuk GG, Skobliakov AV, Golubev AA, Kantsyrev AV, Shimchuk GrG. Assessment of the Possibility of Verification of Proton Dose Distributions by the Method of Induced Positron Activity in Human Tissue. Medical Radiology and Radiation Safety. 2024;69(6):87–93. (In Russian). DOI:10.33266/1024-6177-2024-69-6-87-93
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The work was carried out as part of the fulfillment of the state task of the Kurchatov Institute Research Center.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.07.2024. Accepted for publication: 25.09.2024.