JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
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Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
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The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Medical Radiology and Radiation Safety. 2025. Vol. 70. № 6
DOI:10.33266/1024-6177-2025-70-6-97-101
A. Zherniakova1, V. Yudina1, O. Krysiuk1, 2
Leukopenia of Undetermined Significance in a Person with Long-term Exposure to Ionizing Radiation: a Perspective on Clonal Hematopoiesis (Clinical Case)
1 Russian Research Institute of Hematology and Transfusiolog, Saint Petersburg, Russia
2 Saint Petersburg State University, Saint Petersburg, Russia
Contact person: A. Zherniakova, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Abstract
Relevance: The phenomenon of clonal hematopoiesis (CH) is usually considered as a biological condition that precedes the development of a number of diseases and pathological processes, primarily haematological malignancies (HM). The concept of CH includes a number of conditions, among which is idiopathic cytopenia of undetermined significance (ICUS), which is defined in the presence of persistent cytopenia in more than one hematopoietic germ and the absence of criteria for myeloid neoplasm and other HM. CH is preceded by the occurrence of genomic instability and the appearance of genetic defects at various levels. The study of factors that can contribute to the transformation of CH into a pathological process is the field of particular interest is. It has been established that low doses of ionizing radiation (IR) is capable of inducing damage at the genetic and epigenetic levels. The dependence of the IR effect on the radiation dose is non-monotonic and polymodal. Recently, data has emerged that the action of small doses of IR can lead to genomic instability, and therefore may cause CH.
Purpose: The aim of this study was to present a clinical case for further discussion of the optimal medical tactics for treatment of a patient with leukopenia of undetermined significance and a history of prolonged contact with IR.
Material and methods: A patient, who had almost 40 years of contact with IR that did not exceed the maximum permissible annual dose (20 mSv per year), underwent a comprehensive examination and observation for two years. All diagnostic and therapeutic measures were performed according to the current National Clinical Guidelines of the Russian Federation, as well as International Standards and Protocols.
Results: The program of examination and monitoring of various parameters in a patient with leukopenia of undetermined significance and a long-term contact with IR is presented and discussed. It included both routine examinations and highly specific hematological and other studies in order to conduct a comprehensive assessment of the patient’s condition and the risks of various pathological conditions. Conclusion: The study of the effect of radiation-induced genetic instability on the clonal expansion is relevant for health monitoring and preventive diagnostics of HM and somatic pathology in individuals with long-term contact with IR in small doses.
Keywords: ionising radiation, professional exposure, clonal hematopoiesis, leukopenia of undetermined significance
For citation: Zherniakova A, Yudina V, Krysiuk O. Leukopenia of Undetermined Significance in a Person with Long-term Exposure to Ionizing Radiation: a Perspective on Clonal Hematopoiesis (Clinical Case). Medical Radiology and Radiation Safety. 2025;70(6):97–101. (In Russian). DOI:10.33266/1024-6177-2025-70-6-97-101
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Araticle was prepared with equal participation of the authors.
Editing of the manuscript: O.B. Krysyuk.
Article received: 20.07.2025. Accepted for publication: 25.08.2025.