JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
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The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Medical Radiology and Radiation Safety. 2025. Vol. 70. № 6
DOI:10.33266/1024-6177-2025-70-6-115-120
Yu.V. Varlamova1, K.D. Kurushin2, M.A. Sazonova3, Yu.N. Ilyushenkova1,
S.I. Sazonova1
Experience for Assessing the Radiochemical Purity
of Radiopharmaceutical 99mTc-MIBI in the Radionuclide Diagnostics Department
1 Cardiology Research Institute, Tomsk NRMC, Tomsk, Russia
2 Siberian State Medical University, Tomsk, Russia;
3 Tomsk Polytechnic University Lyceum , Tomsk, Russia
Contact person: Yu.V. Varlamova, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To analyze the accumulated experience and compare the results of radiochemical purity (RCP) assessment of the 99mTc-MIBI with the quality of myocardial perfusion images (MPI).
Material and methods: From October 2023 to March 2025, a total of 1,163 RCP analyses of ⁹⁹ᵐTc-MIBI were conducted using thin-layer chromatography (TLC) in the Department of Nuclear Medicine of the Cardiology Research Institute, Tomsk NRMC. Intra- and inter-operator reproducibility of TLC results were evaluated using the intraclass correlation coefficient (ICC, 95 % CI). The retrospective study included 100 patients who underwent myocardial perfusion imaging. Diagnostic image quality was independently assessed by two radiologist using both visual evaluation and quantitative analysis (heart-to-liver ratio). Spearman’s correlation coefficient was used to compare TLC results with scintigraphic image quality.
Results: The average content of radiochemical impurities (RCI) in ⁹⁹ᵐTc-MIBI was 9.8 ± 9.95 %. The TLC demonstrated acceptable reproducibility both within and between operators, with intra- and inter-operator ICC values of 0.537 (95 % CI: 0.131–0.790) and 0.786 (95 % CI: 0.376–0.941), respectively. A significant decreasing of the heart-to-liver ratio was observed with increasing of RCI levels: for RCI <10 % – 0.93 (0.79–1.07); for RCI 10–15 % – 0.65 (0.49–0.82); and for RCI 15–20 % – 0.51 (0.46–0.72). In 15 % of cases, the myocardial perfusion images were non-diagnostic, predominantly when RCI exceeded 15 %. Statistically significant indirect correlation between RCI levels and the heart-to-liver ratio (r = –0.581, p = 0.0001), as well as between RCI levels and the visual quality of myocardial perfusion images (r = –0.504, p = 0.0001) was found.
Conclusion: The radiochemical purity of ⁹⁹ᵐTc-MIBI has a direct impact on the diagnostic quality of myocardial perfusion images. For clinical use, the recommended threshold for radiochemical impurities in this radiopharmaceutical should not exceed 15 % (i.e., RCP ≥ 85 %).
Keywords: 99mTc-MIBI, radiochemical purity, thin-layer chromatography, myocardial perfusion scintigraphy
For citation: Varlamova YuV, Kurushin KD, Sazonova MA, Ilyushenkova YuN, Sazonova SI. Experience for Assessing the Radiochemical Purity of Radiopharmaceutical 99mTc-MIBI in the Radionuclide Diagnostics Department. Medical Radiology and Radiation Safety. 2025;70(6):115–120. (In Russian). DOI:10.33266/1024-6177-2025-70-6-115-120
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.07.2025. Accepted for publication: 25.08.2025.