JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
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Medical Radiology and Radiation Safety. 2026. Vol. 71. № 2
DOI:10.33266/1024-6177-2026-71-2-33-39
T.V. Azizova1, E.V. Bragin1, M.V. Bannikova1, N. Hamada2, E.S. Grigoryeva1
The Incidence Risk for Primary Glaucoma and Its Subtypes following Chronic Exposure to Ionizing Radiation in the Russian Cohort of Mayak Nuclear Workers
1 Southern Urals Federal Research and Clinical Center, Ozyorsk, Russia
2 Biology and Environmental Chemistry Division, Sustainable System Research Laboratory,
Central Research Institute of Electric Power Industry (CRIEPI), Chiba 270-1194, Japan
Contact person: Tamara Azizova, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Abstract
Purpose: To assess the incidence risk of primary glaucoma in a cohort of workers affected by chronic exposure.
Material and methods: The studied cohort included all workers first employed at one of the main production facilities of the Mayak Production Association (reactor, radiochemical, and plutonium production plants) between 1948 and 1982, with follow-up until the end of 2018 (n=22,377; 25.4 % women). The average age at hiring was 24.11 (±7.13) years for men and 27.32 (±7.97) years for women (mean ± standard deviation (SD)). The average length of professional employment at the enterprise was 18.04 (±14.28) years. Mean total absorbed dose of external gamma radiation in the brain was 0.46 (±0.67) Gy for men and 0.36 (±0.56) Gy for women. Mean total absorbed dose of neutron radiation was 0.0016 (±0.0043) Gy and 0.0016 (±0.0050) Gy for men and women, respectively. Only confirmed cases of primary glaucoma (572 cases) were included into the analysis. Statistical analysis included estimation of the relative risk (RR) for categorized variables, adjusted for other factors. The excess relative risk per unit dose (ERR/Gy) was estimated using a linear dependence on the total external gamma radiation dose, adjusted (via stratification) for non-radiation factors (sex, attained age, birth cohort) and neutron radiation dose.
Results: A statistically significant relative risk of normal tension glaucoma was found only in the group of workers who received external gamma radiation dose exceeding 1.0 Gy and made up 1.88 (95 % CI: 1.01–3.54; p = 0.047). Dose-response analysis in the cohort of chronically occupationally exposed workers revealed a statistically significant linear relationship between the incidence of normal tension glaucoma and the total dose of external gamma radiation (ERR/Gy = 0.53; 95 % CI: 0.01–1.68; p < 0.05). No statistically significant association was registered between the incidence of primary open-angle glaucoma or primary angle-closure glaucoma and the total dose of external gamma radiation in the studied cohort of workers.
Keywords: primary glaucoma, normal-tension glaucoma, high-tension glaucoma, incidence, Mayak worker cohort, occupational chronic radiation exposure, gamma-ray exposure
For citation: Azizova TV, Bragin EV, Bannikova MV, Hamada N, Grigoryeva ES. The Incidence Risk for Primary Glaucoma and Its Subtypes following Chronic Exposure to Ionizing Radiation in the Russian Cohort of Mayak Nuclear Workers. Medical Radiology and Radiation Safety. 2026;71(2):33–39. (In Russian). DOI:10.33266/1024-6177-2026-71-2-33-39
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.01.2026. Accepted for publication: 25.02.2026.