JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.
Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.
The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.
The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Medical Radiology and Radiation Safety. 2026. Vol. 71. № 2
DOI:10.33266/1024-6177-2026-71-2-81-92
B.Ya. Narkevich1, 2
Is Dosimetry Necessary in Radionuclide Therapy of Patients with Metastases?
1 N.N. Blokhin National Medical Research Center of Oncology, Moscow
2 Association of Medical Physicists of Russia, Moscow
Contact person: B.Ya. Narkevich, E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: Analysis of modern approaches to dosimetric support of radionuclide therapy at the technological stages of dosimetric planning, hospitalization and evaluation of treatment effectiveness.
Material and methods: A comparative analysis of the methodological specifics of dosimetric support of radionuclide therapy with the introduction of radiopharmaceuticals into the body and conventional radiation therapy using sealed sources of ionizing radiation was carried out.
Two methodologically different approaches to dosimetric planning of the level of internal irradiation from a radiopharmaceutical introduced into the patient’s body are considered.
The features of radiation monitoring are discussed both for the patient’s stay in the radionuclide therapy department and his/her safe discharge from the department for others, and for the removed solid and liquid radioactive waste.
A comparative analysis of the functional capabilities of various criteria for assessing the long-term and short-term effectiveness of radionuclide therapy of bone metastases was carried out. Focal absorbed doses of internal irradiation are considered as one of the criteria, for the determination of which a method for their calculation is proposed based on the MIRD formalism and quantitative data from SPECT/CT scanning of an X-ray phantom and a real patient who has been administered a β-γ-emitting therapeutic radiopharmaceutical.
Results: Using a clinical example of radionuclide therapy with 177Lu-PSMA-617 in a patient with stage 4 prostate cancer, dose estimates of internal irradiation of bone metastases by β-particles were obtained. The obtained dosimetric data were compared with efficiency estimates based on metabolic, hematological, hormonal and biochemical parameters, as well as the tumor marker PSA.
Conclusion: Unlike conventional radiation therapy, dosimetric support for planning and evaluating the effectiveness of treatment has not yet become a fundamental methodological basis for modern radionuclide therapy.
Keywords: radionuclide therapy, dosimetric monitoring, treatment planning, radiation monitoring, treatment effectiveness
For citation: Narkevich BYa. Is Dosimetry Necessary in Radionuclide Therapy of Patients with Metastases? Medical Radiology and Radiation Safety. 2026;71(2):81–92. (In Russian). DOI:10.33266/1024-6177-2026-71-2-81-92
References
- Gleisner K.S., Chouin N., Gabina P.M., et al. EANM Dosimetry Committee Recommendations for Dosimetry of 177Lu‑labelled Somatostatin‑Receptor ‑ and PSMA‑Targeting Ligands. Eur J Nucl Med Mol Imaging. 2022;49:1778–809. Doi.: 10.1007/S00259-022-05727-7.
- Kratochwil C., Fendler W.P., Eiber M., et al. Joint EANM/SNMMI Procedure Guideline for the Use of 177Lu‑labeled PSMA‑Targeted Radioligand‑Therapy (177Lu‑PSMA‑RLT). Eur J Nucl Med Mol Imaging. 2023;50:2830–45. Doi: 10.1007/S00259-023-06255-8.
- Sgouros G., Bodei L., McDevitt M.R., Nedrow J.R. Radiopharmaceutical Therapy in Cancer: Clinical Advances and Challenges. Nature Reviews: Drug Discovery. 2020;19:589-608.
- Narkevich B.Ya., Dolgushin M.B., Krylov V.V., Meshcheryakova N.A., Nevzorov D.I. Functional Optimization of Radionuclide Pairs in Prostate Cancer Theranostics. Onkologicheskiy Zhurnal: Luchevaya Diagnostika, Luchevaya Terapiya = Journal of Oncology: Diagnostic Radiology and Radiotherapy. 2020;3;1:38-56 (In Russ.).
- ICRU Report 96. Dosimetry-Guided Radiopharmaceutical Therapy. Journal of ICRU. 2021;21:1. Doi: 10.1177/14736691211060117.
- Bentzen S.M., Constine L.S., Deasy J.O., et al. Quantitative Analyses of Normal Tissue Effects in the Clinic (QUANTEC): an Introduction to the Scientific Issues. Int J Radiat Oncol Biol Phys. 2010;76;3.Suppl:S1–S160.
- Narkevich B.Ya., Dolgushin B.I. Radiation Safety in Interventional Radiology. Ed. Dolgushin B.I. Interventsionnaya Radiologiya v Onkologii = Interventional Radiology in Oncology. National Guidelines. Moscow, Vidar-M Publ., 2022. P. 51-66 (In Russ.).
- Sanitary and Epidemiological Requirements for Radiation Safety of the Population when Handling Ionizing Radiation Sources. SanPiN 2.6.4115–25. (In Russ.).
- Sanitary Rules for Handling Radioactive Waste (SPORO-2002) (as Amended and Supplemented on September 16, 2013) (In Russ.).
- Narkevich B.Ya. Current Issues of Radioactive Waste Management in Nuclear Medicine. Radioaktivnyye Otkhody = Radioactive Waste. 2022;1:28-37 (In Russ.).
- Narkevich B.Ya., Ryzhov S.A., Geliashvili T.M., Smirnov G.Yu. Technologies for the Removal of Liquid Radioactive Waste in Radionuclide Therapy Departments. Meditsinskaya Fizika = Medical Physics. 2024;3:52-64 (In Russ.).
- Rosciyskiye Klinicheskiye Rekomendatsii po Diagnostike i Lecheniyu Limfoproliferativnykh Zabolevaniy = Russian Clinical Guidelines for the Diagnosis and Treatment of Lymphoproliferative Diseases. Ed. by Poddubnaya I.V., Savchenko V.G. Moscow, MediaMedika Publ., 2014. 324 p. (In Russ.).
- Gelezhe P.V., Morozov S.P., Mandel’blat Yu.E., Libson Ye.I. What’s New in the Criteria for Assessing Oncological Diseases in Radiation Diagnostics: RECIST vs. PERCIST. Luchevaya Diagnostika i Terapiya = Diagnostic Radiology and Radiotherapy. 2014;2:28–36 (In Russ.).
- Narkevich B.Ya., Krylov A.S., Ryzhkov A.D. Simplified Method for Calculating Internal Irradiation Doses of Bone Metastases during Radionuclide Therapy. Meditsinskaya Fizika = Medical Physics. 2023;1:48-57 (In Russ.).
- Chipiga L.A., Lavreshov D.D., Vodovatov A.V., et al. Experimental Assessment of Absorbed Doses in Pathological Foci during Radionuclide Therapy with 225Ac-PSMA-617 and 225Ac-DOTA-TATE. Meditsinskaya Fizika = Medical Physics. 2023;4:40-50 (In Russ.).
PDF (RUS) Full-text article (in Russian)
Conflict of interest. The author declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. The article was prepared with the author’s participation.
Article received: 20.01.2026. Accepted for publication: 25.02.2026.