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The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
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Medical Radiology and Radiation Safety. 2019. Vol. 64. No. 6. P. 44–50
DOI: 10.12737/1024-6177-2019-64-6-44-50
Yu.L. Rybakov1,2, V.M. Gukasov1,2, Yu.P. Kozlov1
Effect of General Impact of Weak Low Frequency Vortex Magnetic Field on the System of Natural Antitumor Resistance of the Body
1. Interregional Public Organization “Russian Ecological Society”, Moscow, Russia.
E-mail:
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;
2. Federal Research Centre for Project Evaluation and Consulting Services, Moscow, Russia
Yu.L. Rybakov – Director, Dr. Sci. Biol.;
V.M. Gukasov – Chief Researcher, Dr. Sci. Biol.;
Yu.P. Kozlov – President, Dr. Sci. Biol.
Abstract
Purpose: Experimental study of the antitumor mechanism of increasing the functional activity of phagocytes with a general effect on the body of a weak low-frequency vortex magnetic field (VMP).
Material and methods: The functional activity of phagocytes was assessed upon activation by the intensity of chemiluminescence (CHL) on a Biolumat instrument (model LB 9500, by Berthold, Germany). Samples for in vitro and in vivo experiments were prepared according to generally accepted protocols. The impact of the VMP (Vmax = 3.0 mTl, f = 100 Hz) was performed using a Magnitoturbotron magnetotherapeutic installation (developed by NPF Az).
Results: It was found in vitro experiments that the exposure of a suspension of VMP cells stimulated an increase in CHL by 58 % relative to the control, while the main contribution to the intensity of the signal of the CHL was made by neutrophils. In the study of the blood CHL of mice with subcutaneously inoculated melanoma B-16, it was established that the value of the specific CHL in the experiment with VFM by the end of the observation period (day 17) increased sharply (3 times) relative to the beginning of the observation and to the control at the same observation period was 3.3 times more. Experiments with whole blood of healthy donors and patients with breast cancer showed that the CHL curves over time were biphasic in nature and had two maxima, but the phase ratio was different. At donors, the main luminescence developed by the 100th minute, and a maximum of 30–40 min was mild. In patients with breast cancer, the first maximum at 30–40 min was the main, the second maximum was weak and came later than that of donors. Experiments with the effects of VMP on the organism of healthy and patients with breast cancer of people showed an increase in the functional activity of neutrophils as a result of exposure to VMP, but in patients with breast cancer, the level of CHL was significantly (3 times) higher than of healthy donors. Based on the research, it was concluded that exposure to the VMP is able to form a priming neutrophil.
Сonclusion: It is shown that the overall effect of weak low-frequency VFM increases the level of nonspecific resistance of the organism to the tumor process, which expands the possibilities of rehabilitation of patients, allows expanding the compensatory capabilities of the body and reduce the risk of disease.
Key words: vortex magnetic field, magnetobiological effects, homeostasis, oxidation-reduction reactions, antitumor resistanse
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For citation: Рыбаков Ю.Л., Гукасов В.М., Козлов Ю.П. Влияние низкочастотного вихревого магнитного поля на состояние системы естественной противоопухолевой резистентности организма. Medical Radiology and Radiation Safety. 2019;64(6):44–50. (in Russian).
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