JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.
Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.
The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
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The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Medical Radiology and Radiation Safety. 2019. Vol. 64. No. 6. P. 64–69
DOI: 10.12737/1024-6177-2019-64-6-64-69
I.M. Lebedenko1,3, B.M. Gavrikov2, T.N. Borisova1
Method of Quatitative Evaluation of the Size and Density of the Tumor During Adaptive Radiotherapy Using CT Images
1. N.N. Blokhin National Medical Research Center, Moscow, Russia;
2. Moscow Municipal Oncology Hospital No. 62, Moscow, Russia;
3. National Research Nuclear University “MEPhI”, Moscow, Russia;
E-mail:
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I.M. Lebedenko – Senior Researcher, Dr. Sci. Biol., Member of American Association of Physics in Medicine, Assoc. Prof.;
B.M. Gavrikov – Medical Physicist, Post-Graduate Student;
T.N. Borisova – Senior Researcher, PhD Med.
Abstract
Purpose: Clinically available quantitative method for assessing the dynamics of the size and physical density (in g/cm3) of the tumor in adaptive radiotherapy for cancer patients and any cases of visualization of tumor boundaries including the cases when the border of a tumor is not clearly visualized.
Material and methods: A preliminary analysis of the images transmitted over the CT network was carried out in the Eclipse planning system (PS). The radiotherapy treatment planning using electron accelerators with a multi-leaf collimator( Varian (USA)) was carried out at the Eclipse PS. The image quality control of Light Speed RT 16 (manufactured by GE) X-ray computed tomography scanner was performed using the multi-modular phantom Catphan® 504. The assessment of the densitometric characteristics CT imaging made using eight tissue-equivalent a test object with mass densities from 0.03 to 1.37 g/cm3 which corresponding to the density of biological tissues of the human body. To quantify the size and density of the tumor in a dynamic mode, we have written and used our own Matlab program installed on a separate computer. For lossless compression of graphic information, the PNG-image scale (raster graphic information storage format) is used, which is equivalent to the scale of the original DICOM file at the Eclipse PS. A program consists of subroutines that include calibration, contour integration, and integration along a horizontal line.
Results: The quantitative information content of the method is shown. The method is used in clinical practice.
Conclusions: A clinically available quantitative method for assessing dynamics of the size and physical density of the tumor has been developed and proposed for use in adaptive radiatiotherapy for cancer patients for any cases of visualization of tumor boundaries. When a positive dynamics in the tumor, the integral index is greater than 1 (M > 1), when a negative dynamics (in the absence of response to treatment) M ≤ 1. Quantitative characteristics are objective, do not depend on the subjective assessments of personnel and can serve as a basis for rescheduling exposure plans.
Key words: adaptive radiotherapy, CT images, assessing the tumor size and density, programmatic method
REFERENCES
1. Stavitsky RV. Aspects of Clinical Dosimetry. Moscow. MNPI; 2000. 388 p. (In Russian).
2. Lebedenko IM. Quantitative Criteria for Assessing of Changes in Tumor and Normal Tissues During Radiotherapy. Moscow. Diss. PhD Biol; 2005 (In Russian).
3. Quality Control in Radiotherapy And Radiation Diagnosis. Collection of Normative Documents. Minsk. Poliprint; 2009. 272 p. (In Russian).
4. IEC: Evaluation and routine testing in medical imaging departments 61223-3-5 Part 3-5: Acceptance tests – Imaging performance of computed tomography X-ray equipment. Geneva. Switzerland; 2004.
For citation: Lebedenko IM, Gavrikov BM, Borisova TN. Method of Quatitative Evaluation of the Size and Density of the Tumor During Adaptive Radiotherapy Using CT Images. Medical Radiology and Radiation Safety. 2019;64(6):64–69. (in Russian).
PDF (RUS) Full-text article (in Russian)