JOURNAL DESCRIPTION

The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.

Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.

Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.

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Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.

The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.

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The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.

Medical Radiology and Radiation Safety. 2021. Vol. 66. № 4. P. 18–24

Changes in the Cortex Neurons in Single and Fractional Gamma Radiation

I.B. Ushakov, V.P. Fyodorov

A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia

Contact person: Vladimir Petrovich Fyodorov: This email address is being protected from spambots. You need JavaScript enabled to view it.  

Abstract

Purpose: Comparative assessment of radiation-induced changes in neurons of the cerebral cortex after a single and fractionated exposure to ionizing radiation in doses of 0.1 – 1.0 Gy.

Material and methods. The study was carried out in compliance with the rules of bioethics on 180 white outbred male rats at the age of 4 months. by the beginning of the experiment, exposed to a single or fractionated exposure to γ-quanta of 60Co in total doses of 0.1; 0.2; 0.5 and 1.0 Gy. Neuromorphological and histochemical methods were used to assess morphometric and tinctorial parameters of nerve cells, as well as changes in the content of protein and nucleic acids in neurons in the early and late periods of the post-radiation period. Using one-way analysis of variance, a comparative assessment of neuromorphological indicators under various modes of radiation exposure is given.

Results: In the control and irradiated animals throughout their life, undulating changes in the indicators of the state of the neurons of the brain occur with a gradual decrease by the end of the experiment. Despite a number of features of the dynamics of neuromorphological parameters, these irradiation regimes do not cause functionally significant changes in the neurons of the cortex. However, in some periods of the post-radiation period, the changes under the studied irradiation regimes were multidirectional and did not always correspond to age control. Significant differences in the response of neurons to these modes of radiation exposure in the sensory and motor areas of the cerebral cortex have not been established.

Conclusion: No functionally significant radiation-induced changes in neurons were found either with single or fractionated irradiation. At the same time, different modes of irradiation in general caused the same type of changes in neurons. However, in some periods of observation, changes in neuromorphological parameters under the studied irradiation regimes were not unidirectional and differed from age control, which indicates a possible risk of disturbances in the functioning of the nervous system against the background of other harmful and dangerous factors.

Keywords: low doses of radiation, irradiation, brain, changes in neurons, rats

For citation: Ushakov IB, Fyodorov VP. Changes in the Cortex Neurons in Single and Fractional Gamma Radiation. Medical Radiology and Radiation Safety. 2021;66(4):18-24.

DOI: 10.12737/1024-6177-2021-66-4-18-24

 

References

1 Guskova AK Radiation and the Human Brain. Honey. Radiology and Radiation. Safety. 2001. 46(5): 47–55. (In Russian).

2 Legeza VI, Reznik VM, Pimburskiy VF. On the Peculiarities of the Long-term Dynamics of the Levels of Diseases of the Circulatory System in Servicemen who Liquidate the Consequences of the Accident at the Chernobyl Nuclear Power Plant. Med.-biol. and Social Psychology. Probl. Safety in Emergency Situations. 2016. V.1. P.34-40. (In Russian).

3 Nikiforov AM, Aleksanin SS, Chugunova LN Features of the Psychological Status and Medical and Psychological Rehabilitation of Participants in Emergency Recovery Work at the Chernobyl NPP. Medical Radiology and Radiation safety. 2002.47(5): 43–50. (In Russian).

4 Torubarov FS, Kuleshova MV, Lukyanova SN, Zvereva ZV Spectral Correlation Analysis of EEG in Liquidators of the Chernobyl Accident with Neurological Disorders. Medical Radiology and Radiation Safety. 2019. 64(3): 40–45. (In Russian).

5 Ushakov IB, Fedorov VP, Gundarova OP Neuromorphological Correlates of Minor Radiation Effects. Med.-biol. and Social Psychology. Probl. safety in Emergency Situations. 2016. 1: 71–78. (In Russian).

6 Shamrey VK, Chistyakova EI, Matyshina EN et.al. Radiation Psychosomatic Illness Among Liquidators of the Consequences of the Accident at the Chernobyl Nuclear Power Plant. Med.-biol. and Social Psychology. Probl. Safety in Emergency Situations. 2016. 1: 21–33. (In Russian).

7 Fedorov VP, Ushakov IB, Fedorov NV Cerebral Effects in the Liquidators of the Chernobyl Accident. Saarbrücken: LAP LAMBERT Academic Publishing, Moscow, Publ, 2016. 390 с. (In Russian).

8 Aleksanin SS Pathogenetic Laws of the Formation of Somatic Pathology After Radiation Accidents in the Remote Period. Bull. Grew up. Military Medical Acad. 2008. 23(3): 10–13. (In Russian).

9 Buzunov VA The Main Results and Tasks of Epidemiological Studies of the Medical Consequences of the Accident at the Chernobyl Nuclear Power Plant (Results of 4-year Observations). Vestn. Academy of Medical Sciences of the USSR. 1991. 11: 36–39.  (In Russian).

10 Ushakov IB, Fyodorov VP. Low Radiation Impacts and Brain. Voronezh: Nauchnayakniga. Moscow, Publ, 2015. 536 P. (In Russian).

11 Ushakov IB, Fedorov VP Neuromorphological Correlates of Prolonged Radiation Exposure. Med.-biol. and social Psychology. Probl. Safety in Emergency Situations. 2018. 3: 86–97. (In Russian).

12 Ushakov IB, Fyodorov VP, Sgibneva NV. The neuromorphological Correlation of Radiation Dose Rate. Medico-Biological and Socio-Psychological Problems of Safety in Emergency Situations. 2019. 4: 59–69. (In Russian).

13 Radiation Effects. Voronezh: Scientific. book. Moscow, Publ, 2013. 256. (In Russian).

14 Sgibneva NV, Fyodorov VP, Gundarova OP, Maslov NV. Plasticity of Sensorimotor Cortex Neurons in Conditions of High Radiation Background. Medical Radiology and Radiation Safety. 2017. 61(1): 20-26. (In Russian).

15 Fyodorov VP, Petrov AV, Stepanyan NA. Ecological Geomorphology. Classification of Typical Forms of Morphological Variability of the Central Nervous System Under the Action of Anthropogenic Factors. Journal of Theoretical and Practical Medicine. 2003. 1: 62–66. (In Russian).

 PDF (RUS) Full-text article (in Russian)

Conflict of interest. The authors declare no conflict of interest.

Financing. The study had no sponsorship.

Contribution. Article was prepared with equal participation of the authors.

 

Article received: 16.03.2021. 

Accepted for publication: 21.04.2021.

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