JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.
Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.
The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.
The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Medical Radiology and Radiation Safety. 2021. Vol. 66. № 4. P. 62–69
Subacute Course of Chronic Radiation Syndrome Caused External
Non-Uniform Radiation Exposure of Lost Source
I.A. Galstyan, A.Yu. Bushmanov, N.A. Metlyaeva, V.Yu. Soloviev, L.Yu. Mershin, M.V. Konchalovsky,
V.Yu. Nugis, O.V. Shcherbatykh, L.A. Yunanova, F.S. Torubarov, A.A. Davtian, E.E. Obuhova
A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia
Contact person: Irina Alekseevna Galstyan: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To analyze the features of the clinical course of chronic radiation syndrome (CRS) due to external non-uniform chronic exposure to prolonged household contact with a lost source of ionizing radiation.
Material and methods: Analysis of 2 clinical observations of patients who developed subacutecourse of CRS and chronic radiation dermatitis due to external non-uniform exposure of the lost sources of ionizing radiation are presented.
Results: Boy A. K. from the age of 1 year for 7 years was external radiation exposed (for 1.5 years non-uniform exposure ) to the total dose according EPR tooth enamel about 6.3 Gy, according to the data of retrospective dose recovery on red bone marrow using voxel modeling – 26 (19–37) Gy.
F. V. V., male, 38 years, was external non-uniform radiation exposed for 5 months, the total dose according cytogenetic studies of 7.9 Gy (dose rate about 0.035 Gy/h).
During the examination in the hospital, the patients were diagnosed with CRS. Within the framework of the bone marrow syndrome, deep thrombocytopenia, moderate leuko- and neutropenia, and moderate anemic syndrome were observed. The latter is not typical for the typical course of CRS and is a criterion indicating a subacute course of the disease. In addition, signs of chronic radiation dermatitis were found in the projection of the action of the ionizing radiation beam. After stopping the radiation exposure, the patients did not recover their hematopoietic function, and in the period of immediate consequences, they developed myelodysplastic syndrome (MDS) with further transformation into acute leukemia.
Conclusion: 1. Accidental prolonged household or criminal contact with a source of ionizing radiation can lead to the formation of CRS with an atypical subacute course and the formation of MDS with transformation to acute leukemia in the outcome of the disease or in the period of its consequences.
2. It can be assumed that with external non-uniform radiation exposure, leading to the development of CRS and chronic radiation damage to the skin, agranulocytosis in the subacute course of CRS may be absent.
3. Adverse prognostic signs for the development of MDS and leukemia in the outcome or in the period of the consequences of subacute CRS with non-uniform exposure are long-lasting deep thrombocytopenia and anemic syndrome after the end of radiation exposure.
Keywords: chronic radiation syndrome, subacute course, non-uniform radiation exposure, lost radiation source, agranulocytosis, anemic syndrome, myelodysplastic syndrome, acute leukemia
For citation: Galstyan IA, Bushmanov AYu, Metlyaeva NA, Soloviev VYu, Mershin LYu, Konchalovsky MV, Nugis VYu, Shcherbatykh OV, Yunanova LA, Torubarov FS, Davtian AA, Obuhova EE. Subacute Course of Chronic Radiation Syndrome Caused External Non-Uniform Radiation Exposure of Lost Source. Medical Radiology and Radiation Safety. 2021;66(4):62-69.
DOI: 10.12737/1024-6177-2021-66-4-62-69
References
1. Galstyan IA, Metlyaeva NA, Konchalovsky MV, Nugis VYu, Shcherbatykh OV, Yunanova LA, et al. "Subacute” course of chronic radiation syndrome. Medical Radiology and Radiation Safety. Accepted for publication. (In Russian)].
2. Krasnyuk VI, Konchalovsky MV, Ustyugova AA. Clinical features of subacute course of radiation disease. Saratov Journal of Medical Scientific Research. 2014;10(4):858-862. (In Russian)].
3. Hwang S-L, Guo H-R, Hsieh W-A, Hwang J-S, Lee S-D, Tang J-L, et al. Cancer risks in a population with prolonged low dose-rate gamma-radiation exposure in radiocontaminated buildings, 1983-2002. Int J Radiat Biol. 2006;82(12):849-58. DOI: 10.1080/09553000601085980.
4. ICRP Publication. 110. Adult Reference Computational Phantoms. SAGE Publications Ltd. May 2010: 166.
5. S. Agostinelli et al. Geant4 – A Simulation Toolkit, Nucl. Instrum. Meth. A 2003;506. 250-303.
6. J. Allison et al. Geant4 – Developments and Applications, IEEE Trans. Nucl. Sci. 2006;53:270-278.
7. S. Agostinelli et al. Geant4 – A Simulation Toolkit, Nucl. Instrum. Meth. A 2003;506: 250-303.
8. Sevan’kaev AV, Khvostunov IK, Snigiryova GP, Novitskaya NN, Antoschina MM, Fesenko EV, et al. Comparative analysis of cytogenetic examination of control groups of subjects carried out in different russian laboratories. Radiatsion biology, radioecology. 2013;53(1):5-24. (In Russian).
9. Cytogenetic dosimetry: Applications in preparedness for and response to radiation emergencies. Vienna: IAEA, 2011. 229 p.
10. Snigiryova GP, Bogomazova AN, Novitskaya NN, Hazins ED, Rubanovich AV. Biological indication of radiation exposure to the human body using cytogenetic methods. Medical Technology No.FS-2007/015-U. Moscow, 2007. 29 p. (In Russian)]
11. Nugis VYu, Dudochkina NEu. The regularities of chromosome aberrations elimination in lymphocyte cultures of the peripheral blood of people in late times after acute irradiation. Radiatsion biology, radioecology. 2006;46(1):5-16. (In Russian)].
12. Baranov AE, Guskova AK, Davtian AA, Sevan`kaev AV, Lloid DC, Edwards AA, et al. Protracted overexposure to a 137Cs source: II. Clinical sequelae. Radiation Protection Dosimetry. 1999;81(2):91-100.
13. Sevan`kaev AV, Lloid DC, Edwards AA, Mikhailova GF, Nugis VYu, Domracheva EV, et al. Protracted overexposure to a 137Cs source: I. Dose Reconstruction. Radiation Protection Dosimetry. 1999;81(2):85-90.
14. Nugis VYu, Snigiryova GP, Lomonosova EE, Kozlova MG, Nikitina VA. Three-color FISH method: dose-effect curves for translocations in peripheral blood lymphocyte cultures after gamma-irradiation in vitro. Medical Radiology and Radiation Safety. 2020;65(5):12-20. (In Russian).
15. Myelodysplastic syndrome. Clinical Recommendations. 2020; 94 p. (In Russian)].
16. Selidovkin GD, Barabanova AV. Acute radiation syndrome caused general radiation Exposure. In: Radiation Medicine. Ed.: Iljin LA. IzdAT, 2001;2:62-89 (In Russian)].
PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 16.02.2021.
Accepted for publication: 20.04.2021.