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The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
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Medical Radiology and Radiation Safety. 2021. Vol. 66. № 6. P. 93–98
Determination of Monitor Doses in Neutron Therapy Using the U-120 Cyclotron
V. А. Lisin
Cancer Research Institute, Tomsk National Research Medical Center, Tomsk, Russia
Contact person: Valery Andreevich Lisin, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Abstract
Purpose Analyze the various methods for determining the monitor doses in neutron therapy using the U-120 cyclotron and to choose the monitoring method that provides the highest accuracy in dose delivery to the tumor.
Material and methods The distributions of the absorbed dose of the therapeutic beam from the U-120 cyclotron were measured in a tissue-equivalent medium using the differential method, in which two ionization chambers with different sensitivity to neutron radiation were used. A comparison of radiation effects on tissues using various techniques of determining the monitor doses was made. The linear-quadratic model was used to assess responses to ionizing radiation.
Results Dosimetry studies revealed that the therapeutic beam of the U-120 cyclotron contains concomitant gamma radiation, the contribution of which to the total neutron-photon dose increases with increasing depth of the irradiated medium. The presence of gamma radiation in the neutron beam dictate the need to find the correct method for monitoring neutron therapy. A comparison of radiation effects on the tumor tissue using different techniques of determining the monitor doses was made. It was found that at equal neutron-photon doses, the neutron dose in the tumor changed depending on its depth. It can lead to an incorrect conclusion about the effectiveness of neutron therapy depending on a single dose as well as in relation to various dose fractionation schedules.
Conclusion The analysis of the results obtained showed that the problem can be most accurately solved using a technique in which the monitor coefficient and monitor doses are determined from the distribution of the neutron dose, taking into account the contribution of the gamma radiation dose to the total neutron-photon dose.
Key words: neutron therapy, monitor doses, linear quadratic model
For citation: Lisin VА. Determination of Monitor Doses in Neutron Therapy Using the U-120 Cyclotron. Medical Radiology and Radiation Safety. 2021;66(6):93–98.
DOI: 10.12737/1024-6177-2021-66-6-93-98
References
1. Zyryanov B.N., Afanasyev S.G., Zavyalov A.A., Musabayeva L.I. Intraoperative radiation therapy. - Tomsk. 1999.277 p.
2. Musabayeva L.I., Zhogina Zh. A., Slonimskaya E.M., Lisin V.A. Modern methods of radiation therapy. - Tomsk. 2003.199 p.
3. Musabayeva L.I., Lisin V.A., Startseva Zh.A., Gribova O.V. et al. Neutron therapy using the U-120 cyclotron // Medical Radiology and Radiation. Safety. 2013. V. 58. No. 2. P. 53-61.
4. Wagner F. M., Specht H., Loeper-Kabasakal B., Breitkreutz H. The current state of fast neutron therapy // Siberian Journal of Oncology. 2015. No. 6. P. 5-11.
5. Gulidov I. A., Mardynsky Yu. S., Tsyb A. F., Sysoev A. S. Neutrons of nuclear reactors in the treatment of malignant neoplasms. - Obninsk: Publishing house of MRRC RAMS. 2001.132 p.
6. Vazhenin A. V., Rykovanov G. N. Ural center of neutron therapy: history of creation, methodology, results of work. - M .: Publishing house of the Russian Academy of Medical Sciences. 2008.124 p.
7. Kandakova E. Yu. Clinical and experimental substantiation of increasing the efficiency of combined photon-neutron therapy of head and neck tumors. - Doctoral dissertation. Moscow. 2015.197 p.
8. Shalnov M.I. Tissue dose of neutrons. –M: Atomizdat. 1960. 218 p.
9. Bregadze Yu. I. Methods of measuring the absorbed dose of neutron radiation by the ionization method. - Moscow. 1989. 20 p.
10. Lisin V.A., Gorbatenko A.I. Heterogeneous ionization chambers for dosimetry of mixed fields of fast neutrons and gamma radiation.- Instruments and experimental techniques. 1989. No. 6. P.71-73.
11. Kondratjeva A.G., Kolchuzhkin A.M., Lisin V.A., Tropin I.S. Properties of Absorbed Dose distribution in heterogeneous Media // Journal of Physics: Conference Series. 2006. Т. 41, № 1. С. 527-530.
12. Lisin V.A. Estimation of the parameters of the linear-quadratic model in neutron therapy // Medical Physics. 2010. V.48. No. 4. P. 5 - 12.
13. Lisin VA Linear-quadratic model in planning neutron therapy using the U-120 cyclotron // Medical Radiology and Radiation Safety. 2018. V. 63.No. 5. P. 41 – 47.
14. Lisin V.A. On the choice of the ratio of doses of neutrons and photons in neutron-photon therapy of malignant neoplasms. // Medical Radiology and Radiation Safety, 2019. V. 64, No. 6. p. 57–63.
15. Lisin V.A., Musabayeva L.I. Quantitative assessment of radiation-induced reactions of tumors taking into account their radiobiological parameters. // Medical Radiology, 1983, V. 28, P. 65-69.
PDF (RUS) Full-text article (in Russian)
Conflict of interest. The author declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. The article was prepared by one author.
Article received: 07.06.2019.
Accepted for publication: 20.09.2021.