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The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
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Medical Radiology and Radiation Safety. 2022. Vol. 67. № 2
MEASUREMENT OF SOME CHEMICAL ELEMENTS IN NORMAL HUMAN BREAST TISSUE BY NEUTRON-ACTIVATION ANALYSIS
V. Zaichick, G.A. Davydov
A.F. Tsyb Medical Radiological Research Center, Obninsk, Russia
Contact person: V. Zaichick, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To develop the method of chemical element (ChE) content measurement in samples of breast tissue (BT) using the activation by neutrons of nuclear reactor combined with the high-resolution spectrometry of gamma-radiation of short-lived radionuclides (INAA-SLR), and to investigate ChE contents in normal human mammary gland.
Material and methods: In the samples of BT taken from female with intact mammary glands (mostly died from trauma, n = 38) the contents of calcium (Ca), chlorine (Cl), iodine (I), potassium (K), magnesium (Mg), manganese (Mn), sodium (Na), and strontium (Sr) were measured. To determine these element contents, the method of INAA-SLR was developed.
Results: The accuracy of the developed method and the reliability of the results obtained in the study were confirmed by the measurements of international certified reference material IAEA H-4 Animal Muscles and the good agreement with data of its certificate. The main statistic parameters, including, arithmetic mean, standard deviation, standard error of mean, minimum and maximum values, median, percentiles with 0.025 and 0.975 levels was calculated for ChE contents in the normal BT. It was shown, for example, that means of mass fractions ± standard errors of means (M±SEM, mg/kg dry tissue) in normal human mammary gland were: Ca 128±14, Cl 1014±146,
I 0,82±0,11, K 196±20, Mg 80,0±9,4, Mn 0,27±0,04, Na 665±71 и Sr 5,20±0,75. It was found that the Ca, Cl, I, K, Mg, Mn, Na и Sr contents in human mammary gland very differ from the normal level of these elements in whole blood, muscle and adipose tissue, particularly in contents of I and Sr.
Conclusion: The method of INAA-SLR allow to obtain the representative data on Ca, Cl, I, K, Mg, Mn, Na и Sr contents in human BT specimen. It was shown, that such trace elements as I and Sr may be directly involved in the mammary gland function.
Keywords: mammary gland, chemical elements of breast tissue, neutron-activation analysis
For citation: Zaichick V, Davydov GA. Measurement of some chemical elements in normal human breast tissue by neutron-activation analysis. Medical Radiology and Radiation Safety. 2022;67(2):64-68. (In Russian) doi: 10.33266/1024-6177-2022-67-2-64-68
References
1 Gubanov R.A., Safm K.R., Safina S.Z., Baykeev R.F. Evaluation of the Information Content of the Dtfinition of Cancer Markers in Breast Cancer. Kreativnaya Khirurgiya i Onkologiya = Creative Surgery and Oncology. 2011;1:59-67 (In Riss.).
2. White A.J., O’Brien K.M., Niehoff N.M., Carroll R., Sandler D.P. Metallic Air Pollutants and Breast Cincer Risk in a Nationwide Cohort Study. Epidemiol. 2019;30;1:20-28.
DOI:1 (.1097/EDE.0000000000000917.
3. Zaichick V.Ye., Vtyurin B.M., Zherbin Ye.A., Matveyenko Y.G. Sposob Differentsialnoy Diagnostiki Raka Shchitovidnoy Zhelezy = The Certificate on the Method of Differential Diagnosis of Thyroid Cancer. № 619859 of the USSR. 1978 (In Russ.).
4. Bizer V.A., Zherbin Ye.A., Zaichick V.Ye., Kalashnikov V.M., Proshin V.V. Sposob Diagnostiki Novoobrazovaniy Kostey = The Certificate on the Method of Diagnosis of Bone Tumors. № 677748 of the USSR. 1979 (In Russ.).
5. Dunchik V.N., Zherbin YE.A., Zaichick V.Ye., Leonov A.I., Sviridova T.V. Sposob Differentsialnoy Diagnostiki Zlokachestvennykh i Dobrokachestvennykh Opukholey Predstatelnoy Zhelezy = The Certificate for the Method of Differential Diagnosis of Malignant and Benign Prostate Tumors. № 764660 of the USSR. 1980 (In Russ.).
6. Zaichick V.Ye., Tsyb A.F., Dunchik V.N., Sviridova T.V. Sposob Diagnostiki Zabolevaniy Predstatelnoy Zhelezy = The Certificate for the Method of Diagnosis of Prostate Diseases.
№ 997281 of the USSR. Not Subject to Publication in the Open Press. 1982. (In Russ.).
7. Zaichick V.Ye., Tsyb A.F., Vtyurin B.M., Medvedev V.S. Sposob Diagnostiki Skrytogo Raka Shchitovidnoy Zhelezy = The Certificate for the Method of Diagnosis of Latent Thyroid Cancer. № 1096776 of the USSR. 1985 (In Russ.).
8. Shilstein S.Sh., Cortesi M., Breskin A., Chechik R., Vartsky D., Raviv G., Kleinman N., Ramon J., Kogan G., Gladysh V., Moriel E., Huszar M., Volkov A., Fridman E. Prostatic Zn Determination for Prostate Cancer Diagnosis. Talanta. 2006;70:914-921. D01:10.1016/j.talanta.2006.05.053.
9. Costello L.C., Franklin R.B., Feng P., Tan M., Bagasra O. Zinc and Prostate Cancer: a Critical Scientific, Medical and Public Interest Issue (United States). Cancer Causes Control. 2005;16:901-915. DOI: 10.1007/sl0552-005-2367-y.
10. Cortesi M., Fridman E., Volkov A., Shilstein S.Sh., Chechik R., Breskin A., Vartsky D., Kleiman N., Kogan G., Moriel E., Gladysh V., Huszar M., Ramon J., Raviv G. Clinical Assessment of the Cancer Diagnostic Value of Prostate Zn: A Comprechensive Needle-Biopsy Study. The Prostate. 2008;68:994-1006.
11. Costello L.C., Franklin R.B. Prostatic Fluid Electrolyte Composition for the Screening of Prostate Cancer: a Potential Solution to a Major Problem. Prostate Cancer Prostate Dis. 2009;12;1:17-24. DOI: 10.1038/pcan.2008.19.
12. Zaichick V. Medical Elementology as a New Scientific Discipline. J. Radioanal. Nucl. Chem. 2006;269;2:303-309. https://doi.org/10.1007/sl0967-006-0383-3.
13. Zaichick V. Applications of Synthetic Reference Materials in the Medical Radiological Research Centre. Fresenius J. Anal. Chem. 1995;352:219-223. https://doi.org/10.1007/BF00322330.
14. Zaichick V., Zaichick S. Instrumental Effect on the Contamination of Biomedical Samples in the Course of Sampling. Journal of Analytical Chemistry. 1996;51;12:1200-1205.
DOI: 10.4236/jct.2017.82011.
15. Zaichick V. Sampling, Sample Storage and Preparation of Biomaterials for INAA in Clinical Medicine, Occupational and Environmental Health. Harmonization of Health-Related Environmental Measurements Using Nuclear and Isotopic Techniques. Vienna, IAEA, P. 123-133.
16. Zaichick V., Zaichick S. INAA Applied to Halogen (Br and I) Stability in Long-Term Storage of Lyophilized Biological Materials. J. Radioanal Nucl. Chem. 2000;244;2:279-281. hitps://doi.org/l 0.1023/A: 1006734114204.
17. Zaichick V. Losses of Chemical Elements in Biological Samples under the Dry Ashing Process. Trace Elements in Medicine. 2004;5:17-22.
18. Iyengar G.V., Kollmer W.E., Bowen H.G.M. The Elemental Composition of Human Tissues and Body Fluids. A Compilation of Values for Adults. Weinheim-New York, Verlag Chemie, 1978. 151 p.
19. Kizalaite A., Brimiene V., Brimas G., Kiuberis J., Tautkus S., Zarkov A., Kareiva A. Determination of Trace Elements in Adipose Tissue of Obese People by Microwave-Assisted Digestion and Inductively Coupled Plasma Optical Emission Spectrometry. Biol. Trace. Elem. Res. 2019;189;1:10-17. DOI: 10.1007/sl2011-018-1450-7.
20. Chelovek. Mediko-Biologicheskiye Dannyye = Person. Medical and Biological Data. Moscow, Meditsine Publ., 1977. 496 p. (In Russ.).
PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 30.11.2021. Accepted for publication: 30.03.2022.