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The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
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Medical Radiology and Radiation Safety. 2022. Vol. 67. № 4
Transmission of Radiation-Induced Genome Instability
from Irradiated Parents to their Offspring
D.S. Oslina, V.L. Rybkina, T.V. Azizova
Southern Urals Biophysics Institute, Ozyorsk, Chelyabinsk region, Russia
Contact person: Oslina Darja Sergeevna, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. , This email address is being protected from spambots. You need JavaScript enabled to view it.
Abstract
Numerous studies allow to suppose a transmission of radiation-induced genome instability from irradiated parents to their offspring on cell, chromosome and molecular genetic level. This review focuses on transmission of radiation-induced genome instability from irradiated parents to their offspring. Data of genome instability in animal experiments and in offspring of occupationally exposed human or human exposed in a radiation accident, and in offspring of parents exposed to radiotherapy are reviewed. The possible mechanisms of lineage transmission of genome instability are discussed. High dose irradiation can lead to DNA damage, changes in methylation patterns and miRNAs expression in parents and their offspring and result in mutations, chromosome aberration and destabilization of genome. Non-coding RNAs (miRNA, piRNA, nsRNA) are supposed to contribute to transgenerational effects, since they can target genes, change chromatin structure and disregulate gene expression.
Keywords: ionizing radiation, transgenerational effects, genetic effects, epigenetic effects
For citation: Oslina DS, Rybkina VL, Azizova TV. Transmission of Radiation-Induced Genome Instability from Irradiated Parents to their Offspring. Medical Radiology and Radiation Safety. 2022;67(4):10-18. DOI: 10.33266/1024-6177-2022-67-4-10-18
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 15.03.2022. Accepted for publication: 11.05.2022