JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.
Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.
The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.
The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Medical Radiology and Radiation Safety. 2022. Vol. 67. № 4
Anti-Glomerular Basement Membrane Antibody Disease
with Mild Kidney Failure and Without Progression of Lung Pathology: Case Report
Sheikh Zh.V. 1,2, Nikolaev E.V.1, Gazaryan Ya.R.1, Safonova T.D.1, Zakharova E.V. 1,2
1Russian Medical Academy of Continued Professional Education, Moscow, Russia.
2S.P. Botkin’s City Clinical Hospital, Moscow, Russia.
Contact person: Zhanna V. Sheikh; E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Anti-GBM antibody disease (Goodpasture syndromee) is a rare immunecomlpex vasculitis, affecting small vessels, and characterized by rapidly progressive glomerulonephritis and alveolitis. Causative mechanism is defined by the hyperproduction of autoantibodies against the α3-chain of type IV collagen (Goodpasture antigen) with immune complex formation on the glomerular and alveolar basement membrane. Typically patients with fnti-GBM antibody disease present with rapidly progressive (crescentic) glomerulonephritis, more than in half of cases associated with alveolar hemorrhage. Cases of Anti-GBM antibody disease with atypical clinical presentation have been reported.
We report a case of atypical clinical presentation anti-GBM antibody disease with mild renal damage and slow progression of pulmonary involvement. Main CT signs were multiple centrilobular ground glass nodules.
This case report demonstrates that CT with disseminated pulmonary process associated with even mild kidney involvement in patients with high anti-GBM antibodies titers gives a clue to the diagnosis of anti-GBM antibody disease.
Keywords: Goodpasture syndrome, anti-GBM antibody disease, glomerulonephritis, computed tomography, case report.
For citation: Sheikh ZhV, Nikolaev EV, Gazaryan YaR, Safonova TD, Zakharova EV. Anti-glomerular basement membrane antibody disease with mild kidney failure and without progression of lung pathology: case report. Medical Radiology and Radiation Safety. 2022;67(4):96-100. DOI: 10.33266/1024-6177-2022-67-4-96-100
References
1. Jennette J.C., Nickeleit V. Anti-Glomerular Basement Membrane Glomerulonephritis and Goodpasture Syndrome. Heptinstall’s Pathology of the Kidney. Eds. Jennette J.C., Silva F.G., Olson J.L., et al. Philadelphia, Wolters Kluwer, 2015. P. 657–684.
2. Pusey C.D. Anti-Glomerular Basement Membrane Disease. Kidney Int. 2003;64:1535–1550.
3. Fischer E.G., Lager D.J. Anti-Glomerular Basement Membrane Glomerulonephritis: a Morphologic Study of 80 Cases. Am. J. Clin. Pathol. 2006;125:445–450.
4. Silvariño R., Noboa O., Cervera R. Anti-Glomerular Basement Membrane Antibodies. Isr. Med. Assoc. J. 2014;16:727–732.
5. Salama A.D., Levy J.B., Lightstone L., Pusey C.D. Goodpasture's Disease. Lancet. 2001;358:917–920.
6. Nagano, et al. Case Report: Anti-Glomerular Basement Membrane Antibody Disease with Normal Renal Function. BMC Nephrology. 2015;16:185.
7. Savage C.O., Pusey C.D., Bowman C., Rees A.J., Lockwood C.M. Antiglomerular Basement Membrane Antibody Mediated Disease in the British Isles 1980-4. Br. Med. J. (Clin. Res. Ed.) 1986;292:301-304.
8. Cui Z., Zhao M.H., Singh A.K., Wang H.Y. Antiglomerular Basement Membrane Disease with Normal Renal Function. Kidney Int. 2007;72:1403–1408.
9. Bowley N.B., Steiner R.E., Chin W.S. The Chest X-Ray in Antiglomerular Basement Membrane Antibody Disease (Goodpasture's Syndrome). Clin. Radiol. 1979;30:419-429.
10. Sheykh Zh.V., Zakharova Ye.V., Dunayev A.P. Sistemnyye Vaskulity: Vozmozhnosti Sovremennoy Meditsinskoy Vizualizatsii = Systemic Vasculitis: the Possibilities of Modern Medical Imaging. Moscow, Kraft+ Publ., 2019. 172 p. (In Russ.) [Шейх Ж.В., Захарова Е.В., Дунаев А.П. Системные васкулиты: возможности современной медицинской визуализации. М: Крафт+, 2019. 170 с.].
11. Brant W.E., Helms C.A. Fundamentals of Diagnostic Radiology. Lippincott Williams & Wilkins, 2007. ISBN:0781765188.
12. Collard H.R., Schwarz M.I. Diffuse Alveolar Hemorrhage. Clin. Chest Med. 2004;25:583–592.
13. Hansell D.M. Small-Vessel Diseases of the Lung: CT-Pathologic Correlates. Radiology. 2002;225;3:639-653. DOI: 10.1148/radiol.2253011490.
14. Sheikh Zh.W., Safonova T.D Computed Tomography for the Diagnosis of Pulmonary Lesions in Patients with Systemic Vasculitis. Prakticheskaya pulmonologiya. 2019;2:69-74 (In Russ.) [Шейх Ж.В., Сафонова Т.Д. Компьютерная томография в диагностике легочных поражений при системных васкулитах // Практическая пульмонология. 2019. № 2. С. 69-74].
15. Primack S.L., Miller R.R., Müller N.L. Diffuse pulmonary hemorrhage: clinical, pathologic, and imaging features. AJR Am. J. Roentgenol. 1995;164;2:295-300.
16. Foster, Mary H., Basement Membranes and Autoimmune Diseases. Matrix Biology. 2017;57-58:149-168. DOI: 10.1016/j.matbio.2016.07.008.
17. Specks U. Diffuse Alveolar Hemorrhage Syndromes. Curr. Opin. Rheumatol. 2001;13:12–17.
18. Reiser M.F. Multislice CT. Springer Verlag, 2010. ISBN: 3642069681.
19. Levy J.B., Turner A.N., Rees A.J., Pusey C.D. Long-Term Outcome of Anti-Glomerular Basement Membrane Antibody Disease Treated with Plasma Exchange and Immunosuppression. Ann. Intern. Med. 2001;134:1033–1042.
PDF (RUS) Full-text article (in Russian)
Conflict of interest. The author declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors
Article received: 28.03.2022. Accepted for publication: 23.05.2022