JOURNAL DESCRIPTION

The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.

Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.

Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.

The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.

Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.

The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.

Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.

The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.

Medical Radiology and Radiation Safety. 2022. Vol. 67. № 6

DOI:10.33266/1024-6177-2022-67-6-74-78

S.N. Prokhorov1, N.V. Kochergina1,2, A.D. Ryzhkov1,2,A.S. Krylov1, A.B. Bludov1

Comparison of Bone Scan, X-Ray, Spect/Ct and Mri in the Diagnosis
of Bone Metastases in Solid Tumors

1 N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia

2 Russian Medical Academy of Continuous Professional Education, Moscow, Russia

Contact person: Sergei Nikolaevich Prokhorov, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

 

Abstract

Purpose: Comparison of the diagnostic performance of osteoscintigraphy (OSG), X-Ray, the presence of OSG and X-ray, SPECT/CT and a combination of MRI sequences in metastatic lesions of the bones of the skeleton.

Material and methods: The study included 24 patients with bone metastases. The above research methods were used. 

Results: The sensitivity of X-ray, Bone scan, X-ray combined with bone scan, SPECT/CT, T1+DWI, T1+STIR+DWI, T1+T2+STIR+DWI, T1+T2+STIR was 10, 30, 24, 31, 99, 99, 99, 95 % respectively, specificity – 37, 12, 59, 74, 87, 87, 87, 71 % respectively. According to the results of pairwise comparison of true-positive results in groups according to the Wilcoxon test: X-ray < OSG = X-ray + OSG = SPECT / CT < MRI + DWI > MRI.

Conclusion: It follows from the results that the choice of diagnostic method for suspected bone metastases should be determined by the clinical context. MRI will help detect bone metastases at earlier stages of development, and the use of other diagnostic methods included in the study should be accompanied by an understanding of the limitations that are imposed in their use.

Keywords: bone metastases, SPECT/CT, Skeletal scintigraphy, X-ray, MRI, comparison study

For citation: Prokhorov SN, Kochergina NV, Ryzhkov AD,Krylov AS, Bludov AB. Comparison of Bone Scan, X-Ray, Spect/Ct and Mri in the Diagnosis of Bone Metastases in Solid Tumors. Medical Radiology and Radiation Safety. 2022;67(6):74–78. (In Russian). DOI:10.33266/1024-6177-2022-67-6-74-78 

 

References

1. Hernandez R.K., Wade S.W., Reich A., Pirolli M., Liede A., Lyman G.H. Incidence of Bone Metastases in Patients with Solid Tumors: Analysis of Oncology Electronic Medical Records in the United States. BMC Cancer. 2018;18;1:44.

2. Nakanishi K., Kobayashi M., Nakaguchi K., Kyakuno M., Hashimoto N., Onishi H., Maeda N., Nakata S., Kuwabara M., Murakami T., Nakamura H. Whole-Body MRI for Detecting Metastatic Bone Tumor: Diagnostic Value of Diffusion-Weighted Images. Magn. Reson. Med. Sci. 2007;6;3:147-155.

3. Tabotta F., Jreige M., Schaefer N., Becce F., Prior J.O., Nicod Lalonde M. Quantitative Bone SPECT/CT: High Specificity for Identification of Prostate Cancer Bone Metastases. BMC Musculoskelet Disord. 2019;20;1:619.

4. Rager O., Lee-Felker S.A., Tabouret-Viaud C., Felker E.R., Poncet A., Amzalag G., Garibotto V., Zaidi H., Walter M.A. Accuracy of Whole-Body HDP SPECT/CT, FDG PET/CT, and Their Combination for Detecting Bone Metastases in Breast Cancer: an Intra-Personal Comparison. Am. J. Nucl. Med. Mol. Imaging. 2018;8;3:159-168.

5. Yang H.L., Liu T., Wang X.M., Xu Y., Deng S.M. Diagnosis of Bone Metastases: a Meta-Analysis Comparing ¹⁸FDG PET, CT, MRI and Bone Scintigraphy. Eur. Radiol. 2011;21;12:2604-2617.

6. Liu T., Wang S., Liu H., Meng B., Zhou F., He F., Shi X., Yang H. Detection of Vertebral Metastases: a Meta-Analysis Comparing MRI, CT, PET, BS and BS with SPECT. J. Cancer Res. Clin. Oncol. 2017;143;3:457-465.

7. Sergeyev N.I. Radiation Methods in the Diagnosis of Metastatic Lesions of the Skeletal System. Meditsinskaya Vizualizatsiya = Medical Visualization. 2011;4:46 (In Russ.).

8. Sergeyev N.I. Rol i Mesto Sovremennykh Metodov Vizualizatsii v Diagnostike i Otsenke Rezultatov Konservativnogo Lecheniya Bolnykh s Metastaticheskim Porazheniyem Skeleta = The Role and Place of Modern Imaging Methods in the Diagnosis and Evaluation of the Results of Conservative Treatment of Patients with Metastatic Skeletal Lesions. Extended Abstract of Doctor’s thesis in Medicine. 2017 (In Russ.).

9. Glushkov E.A., et al. Efficiency of SPECT/CT in Detecting Bone Metastases in Breast and Prostate Cancer. Sibirskiy Onkologicheskiy Zhurnal = Siberian Journal of Oncology. 2015;6:19-25 (In Russ.).

10. Petrova A.D. Otsenka Effektivnosti Lekarstvennogo Lecheniya Metastazov v Kostyakh u Bolnykh Rakom Molochnoy Zhelezy = Evaluation of the Effectiveness of the Treatment of Bone Metastases in Patients with Breast Cancer. Extended Abstract of Doctor’s thesis in Medicine. 2014 (In Russ.).

11. Kochergina N.V., Prokhorov S.N., Bludov A.B., Ryzhkov A.D., Fedorova A.V., Spirina O.G. The Effectiveness of MRI in Determining the Presence of Bone Metastases in a Controversial Result of SPECT/CT. Luchevaya Diagnostika i Terapiya = Diagnostic Radiology and Radiotherapy. 2020;3;3:93-100 (In Russ.).

12. Munk P.L., Poon P.Y., O’Connell J.X., Janzen D., Coupland D., Kwong J.S., Gelmon K., Worsley D. Osteoblastic Metastases from Breast Carcinoma with False-Negative Bone Scan. Skeletal Radiol. 1997;26;7:434-437.

13. Ryzhkov A.D., Krylov A.S., Shchipakhina Ya.A., Kochergina N.V., Komanovskaya D.A., Bilik M.Ye. Diagnostics of Skeletal Metastases with Using SPECT/CT. Luchevaya Diagnostika i Terapiya = Diagnostic Radiology and Radiotherapy. 2018;1;3:21-26 (In Russ.).

 

 PDF (RUS) Full-text article (in Russian)

 

Conflict of interest. The authors declare no conflict of interest.

Financing. The study had no sponsorship.

Contribution. Article was prepared with equal participation of the authors.

Article received: 20.07.2022. Accepted for publication: 25.09.2022.

 

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46, Zhivopisnaya st., 123098, Moscow, Russia Phone: +7 (499) 190-95-51. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

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