JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
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The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Medical Radiology and Radiation Safety. 2024. Vol. 69. № 1
DOI:10.33266/1024-6177-2024-69-1-92-104
S.A. Sypko, G.N. Bobov, V.E. Vvedensky, A.V. Nazarenkova
Study of 239Pu Microdistribution in Liver of Mayak
Workers Using Neutron-Activated Measurement Method
Southern Urals Biophysics Institute, Ozyorsk, Russia
Contact person: V.E. Vvedensky, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Abstract
Purpose: Conducted research was aimed at studying of microdistribution of 239Pu particles in liver tissues of former MAYAK PA workers. Current research is a continuation of studies of microdistribution of 239Pu particles in lung tissues of former MAYAK PA workers that were conducted earlier and published.
Material and methods: Neutron-induced track method was utilized for studying the distribution of sizes of 239Pu nanoparticles. At Southern Urals Biophysics Institute this method was improved, optimized and adapted for studying of plutonium microdistribution in biological tissues.
Liver samples studying started in 2020. Samples were chosen from Radiobiology Human Tissue Repository SUBI. Liver samples from Voronezh regional pathology and anatomical bureau and Tobolsk regional hospital #3 were obtained within the search of contemporary liver tissues.
Application of liver samples on track detectors and their assembling into plastic box for following irradiation in nuclear reactor at Joint stock company “Institute of Nuclear Materials” was provided similarly to lung samples. Standart pathohistological techniqes were applied. The thickness of liver slides was 5 micrometers.
Basic track count was conducted on the results of 36-minute etching. Single tracks and stars were counted. Stars with high density of tracks that exceeded counting abilities were counted on the results of 9-minute etching either directly (if all tracks were distinct) or in accordance with patent for invention RU 2733491 C2 that enables to calculate the number of tracks in a star by distinct peripheral tracks.
Results: This study quantitatively compares 239Pu microdistribution in liver of three deceased former Mayak PA workers who were exposed to 239Pu by inhalation and three deceased subjects who had been never employed at Mayak PA (from Ozyorsk, Voronezh, Tobolsk). The comparison is made utilizing neutron-activation method of measurement. The results are compared to the results of less-sensitive autoradiographic method. The study demonstrated that the most of 239Pu activity in liver is concentrated in liver lobules. 239PuO2 nanoparticles found didn’t exceed the size of 20 nm. Track density for three liver samples of subjects who had been never employed at Mayak PA differed for less than two times.
Keywords: Plutonium, neutron-activation measurement method, nanoparticles, microdistribution, liver, Mayak PA
For citation: Sypko SA, Bobov GN, Vvedensky VE, Nazarenkova AV. Study of 239Pu Microdistribution in Liver of Mayak Workers Using Neutron-Activated Measurement Method. Medical Radiology and Radiation Safety. 2024;69(1):92–104. (In Russian). DOI:10.33266/1024-6177-2024-69-1-92-104
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.10.2023. Accepted for publication: 27.11.2023.