JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
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Medical Radiology and Radiation Safety. 2024. Vol. 69. № 4
DOI:10.33266/1024-6177-2024-69-4-88-93
R.V. Zelchan, A.A. Medvedeva, O.D. Bragina, A.N. Rуbina,
E.A. Dudnikova, V.V. Visotskaya, V.E. Goldberg, V.I. Chernov
Spect/Ct with a New Radiopharmaceutical “99mtc, Octreotide” in Diagnosis and Evaluation of the Effectiveness of Treatment of Neuroendocrine Tumor of the Lung (Clinical Case)
Cancer Research Institute, Tomsk National Research Medical Center, Tomsk, Russia
Contact person: R.V. Zelchan, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: to demonstrate the possibilities of using SPECT/CT with the new radiopharmaceutical “99mTс, Octreotide” in the diagnosis, assessment of the extent of the process and monitoring of the effectiveness of treatment of neuroendocrine lung tumors.
Material and methods: the presented clinical case examines the medical history of a patient with verified neuroendocrine cancer of the right lung with extensive local spread and the presence of distant lymph node metastases (retroperitoneal lymph nodes) and hematogenous dissemination to bones (ribs and vertebrae). During the initial diagnosis and at the stages of chemotherapy treatment, along with traditional methods of instrumental and laboratory examination, the patient underwent “99mTc, Octreotide” SPECT/CT. The results of the study were assessed visually and using the SUV (standardized accumulation level). When interpreting the results of “99mTc, Octreotide” SPECT/CT with special attention was paid to the dynamics of the SUV indicator at control points for assessing the effectiveness of chemotherapy
treatment.
Results: The results obtained demonstrated the possibility of effective use of “99mTc, Octreotide” SPECT/CT at the stage of primary diagnosis of a neuroendocrine tumor. The data obtained not only confirmed the presence of a malignant tumor of a neuroendocrine nature in the patient, but also made it possible to correctly stage the tumor process, since additional pathological foci were identified in distant lymph nodes and bones. In addition, the use of “99mTc, Octreotide” SPECT/CT during control examinations at the stages of chemotherapy treatment of a patient made it possible to supplement the significance of diagnostic information obtained using traditional research methods and to more reliably assess the effectiveness of the therapy. Already at the first control examination, pronounced positive dynamics were observed after 3 courses of chemotherapy in the form of a decrease in the number of foci of pathological accumulation of “99mTc, Octreotide” and a decrease in the intensity of its inclusion in the remaining areas of the tumor lesion. Also, during further examinations at control points, the opposite – negative dynamics was noted in the form of the appearance of new foci of pathological accumulation of “99mTc, Octreotide”.
Conclusion: The presented experience in the clinical use of “99mTc, Octreotide” SPECT/CT demonstrated the effectiveness and ease of use of this method in patients with neuroendocrine tumors. In addition, the results obtained today make it possible to successfully use the new domestic radiopharmaceutical for the diagnosis of neuroendocrine tumors.
Keywords: radiopharmaceutical, neuroendocrine tumor of the lung, 99mTc-octreotide, SPECT/CT
For citation: Zelchan RV, Medvedeva AA, Bragina OD, Rуbina AN, Dudnikova EA, Visotskaya VV, Goldberg VE, Chernov VI. Spect/Ct with a New Radiopharmaceutical “99mtc, Octreotide” in Diagnosis and Evaluation of the Effectiveness of Treatment of Neuroendocrine Tumor of the Lung (Clinical Case). Medical Radiology and Radiation Safety. 2024;69(4):88–93. (In Russian). DOI:10.33266/1024-6177-2024-69-4-88-93
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The work was carried out with the financial support of the Ministry of Education and Science of Russia. State contract 14.N08.11.0166 for the implementation of applied scientific research and experimental developments for state needs.
Contribution. Zelchan R.V.: collection and analysis of literary material, development of concept and design, analysis and interpretation of data, writing text; Chernov V.I.: development of concept and design, scientific editing of the text, final approval for publication of the manuscript; Rybina A.N., Medvedeva A.A., Bragina O.D.: development of the concept of research, development research design, data analysis; Dudnikova, V.V. Vysotskaya, V.E. Goldberg: collection of material, data analysis.
Article received: 20.03.2024. Accepted for publication: 25.04.2024.