JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.
Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.
The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.
The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Medical Radiology and Radiation Safety. 2017. Vol. 62. No. 3. P. 78-83
DOI: 10.12737/article_5927fdaf3ad417.71072643
SPECT/CT in the Diagnosis of Paget’s Disease (Clinical Case)
A.S. Krylov, A.B. Bludov, A.D. Ryzhkov, S.V. Shiryaev, M.O. Goncharov
N.N. Blokhin Russian Cancer Research Center Moscow. Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
A.S. Krylov – PhD Med., Radiologist, member of the European Association of Nuclear Medicine and Molecular Imaging (EANMMI); A.B. Bludov – PhD Med., Researcher; A.D. Ryzhkov – Dr. Sc. Med., Senior Researcher; S.V. Shiryaev – Dr. Sc. Med., Head of Lab., President of the OSMI, Member of the European Association of Nuclear Medicine and Molecular Imaging (EANMMI), Member of the American College of Nuclear Medicine and Molecular Imaging (ACNMMI), Member of the Society of Nuclear Medicine and Molecular Imaging (SNMMI); M.O. Goncharov – Radiologist
Abstract
This article describes the clinical case of diagnosis of Paget’s disease in asymptomatic patients using hybrid imaging modality SPECT/CT. The literature data of Paget’s disease diagnosis using SPECT/CT are rare.
Paget’s disease is a disease of unknown etiology, which can affect one or more bones. The essence of the process lies in the pathological bone restructuring, characterized by continuous change in processes of resorption and osteosynthesis in the same bone structure. Pathophysiologically Paget’s disease is characterized by three successive phases: 1) the initial stage or osteolytic destruction; 2) an intermediate stage or a stage of mixed bone destruction characterized by a combination of osteolytic areas with increasing osteosclerosis; 3) stabilization or a stage of osteosclerosis with increasing density of the affected bone due to its rough trabecular conversion.
In the diagnosis of Paget’s disease radionuclide scanning is a highly sensitive but low specific method, while the hybrid imaging method of SPECT/CT is characterized by high sensitivity and specificity, allowing at the same time to quantify the activity of the process and estimate structural changes in the bone with the possibility of differential diagnosis with other pathological processes.
Key words: SPECT/CT, Page’s disease, bone scan, clinical case
REFERENCES
- Seton M. Paget’s disease: epidemiology and pathophysiology. Curr. Osteoporos. Rep. 2008. Vol. 6. 4. P. 125-129.
- Healy G.M., Woods C., Heffernan E., McKenna M.J. Paget’s disease of bone: progress towards remission and prevention. Ir. Med. J. 2015. Vol. 108. No. 10. P. 316-317.
- Haslam S.I., Van Hul W., Morales-Piga A. et al. Paget’s disease of bone: vidence for a suspectibility locus on chromosome 18q and for genetic heterogenecity. J. Bone Mineral Res. 1998. No. 13. P. 911-917.
- Korsakova Yu.L. Paget’s disease: current treatment modalities. Modern Rheumatol. J. 2010. No. 2. P. 11-17. (In Russian).
- Cundy T., Rutland M.D., Naot D., Bolland M. Evolution of Paget’s disease of bone in adults inheriting SQSTM1 mutations. Clin. Endocrinol. (Oxf). 2015. Vol. 83. No. 3. P. 315-319.
- Katayama Y., Kohso K., Nishimura A. et al. Detection of measles virus mRNA from autopsied human tissues. J. Clin. Microbiol. 1998. Vol. 36. No. 1. P. 299-301.
- Rodionova S.S., Kolondaev A.F. Paget’s disease. Moscow: GEOTAR Media, 2008. 54 p. (In Russian).
- Theodorou D.J., Theodorou S.J., Kakitsubata Y. Imaging of Paget disease of bone and its musculoskeletal complications: review. AJR Amer. J. Roentgenol. 2011. Vol. 196. Suppl. 6. P. 64-75.
- Minenkov G.O., Shalabayev B.D. Computed tomographic criteria for the diagnosis of variable manifestations of Paget’s disease in the cerebral cranium and facial bones. Vestnik Rentgenologii i Radiologii. No. 4. P. 56-58. (In Russian).
- Al Nofal A.A., Altayar O., BenKhadra K., Qasim Agha O.Q. et al. Bone turnover markers in Paget’s disease of the bone: A Systematic review and meta-analysis. Osteoporos. Int. 2015. Vol. 26. No. 7. P. 1875-1891.
- Vellenga C.J., Bijvoet O.L., Pauwels E.K. Bone scintigraphy and radiology in Paget’s disease of bone: a review. Amer. J. Physiol. Imaging. 1988. No. 3. P. 154-168.
- Balani A., Marda S.S. Images in clinical medicine. Paget’s Disease of Bone. N. Engl. J. Med. 2016. Vol. 374. No. 13. P. 1264-1276.
- Rozhinskaja L.Ja. Paget’s disease. Osteoporosis and osteopathy. 2007. Vol. 2. No. 2. P. 29-31. (In Russian).
- Kutin A.A. Late diagnosis of Paget’s disease. Clinical practice. 2010. Vol. 2. No. 2. P. 37-40. (In Russian).
- Farid K., Caillat-Vigneron N. SPECT-CT improves the identification of Paget’s disease of bone. Joint Bone Spine. 2010. Vol. 77. No. 4. P. 370-371.
- Atlas of Skeletal SPECT/CT Clinical Images. IAEA Human Health Series 34. IAEA. Vienna. 2016. P. 12-13.
For citation: Krylov AS, Bludov AB, Ryzhkov AD, Shiryaev SV, Goncharov MO. ESPECT/CT in the Diagnosis of Paget's Disease (Clinical Case). Medical Radiology and Radiation Safety. 2017;62(3):78-93. Russian. DOI: 10.12737/article_5927fdaf3ad417.71072643
PDF (RUS) Full-text article (in Russian)