JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
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The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Medical Radiology and Radiation Safety. 2025. Vol. 70. № 1
DOI:10.33266/1024-6177-2025-70-1-5-15
L.A. Romodin1, A.A. Moskovskij1, 4, O.V. Nikitenko1, 2, T.M. Bychkova1, 2,
E.D. Rodionova1, 3, O.M. Tyukalova1
Evaluation of the Protective Effect of the Combined Use of Certain Natural Substances in Acute Exposure to Ionizing Radiation by Mice Physiological Parameters
1 A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
2 Institute of Biomedical Problems, Moscow, Russia
3 D. I. Mendeleev Russian University of Chemical Technology, Moscow, Russia
4 National Research Nuclear University MEPhI, Moscow, Russia
Contact person: L.A. Romodin, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Relevance: Due to the high chemical toxicity of effective radioprotectors and the low radioprotective effect of low-toxic compounds, the use of several substances as part of a single therapeutic regimen for the treatment of radiation sickness seems promising.
Purpose: Evaluate the radioprotective effect of several therapeutic regimens using different substances on a number of physiological parameters in male ICR (CD-1) mice acutely exposed to X-ray radiation at a dose of 6.5 Gy.
Material and methods: The regimens studied included the use of riboxin (inosine), phenylephrine, glutathione, copper chlorophyllin, two forms of vitamin E (tocopherol, trolox), ascorbic acid and granulocyte stimulating factor (G-CSF) in the form of pegfilgrastim. Efficacy was assessed based on hematological parameters, the content of thiobarbiturate-reactive products in the liver, changes in the weight of the liver, thymus and spleen 4 days or 7 days after irradiation.
Results: Among the parameters assessed, the most striking picture was given by the level of leukocytes in the blood of mice 4 and 7 days after irradiation. None of the schemes used returned this indicator to the vivar control level. The most pronounced increase in the content of leukocytes, compared with the irradiated control group, was observed in mice that were administered phenylephrine before irradiation, 30 minutes after irradiation – glutathione, the next day – tocopherol and G-CSF, followed by daily administrations of G-CSF. At the same time, in the case of joint administration of copper chlorophyllin with G-CSF, the protective effect completely disappeared, and the general condition of the mice became worse than in the irradiated control group. That is, G-CSF is not compatible with copper chlorophyllin. The result also occurred in the group that received tocopherol, glutathione and ascorbic acid on the day of irradiation, a day later – only glutathione, and after 2, 3 and 4 days – copper chlorophyllin. Only in this group was there a correction of thrombocytopenia, which occurred one week after irradiation. The deterioration of the condition of the mice, up to the death of some animals in the group, was caused by intragastric administration of riboxin 1, 2, 3 and 4 days after irradiation.
Сonclusions: The results of the work update research into the possibility of treating radiation sickness using several substances with a mandatory study of the effects of their pharmacological interactions. Growth factors and low molecular weight compounds with sulfhydryl groups seem to us to be the most promising.
Keywords: X-ray radiation, acute exposure, radioprotective substances, combined use, mice
For citation: Romodin LA, Moskovskij AA, Nikitenko OV, Bychkova TM, Rodionova ED, Tyukalova OM. Evaluation of the Protective Effect of the Combined Use of Certain Natural Substances in Acute Exposure to Ionizing Radiation by Mice Physiological Parameters. Medical Radiology and Radiation Safety. 2025;70(1):5–15. (In Russian). DOI:10.33266/1024-6177-2025-70-1-5-15
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Conflict of interest. The authors declare no conflict of interest.
Financing. The research was carried out at the expense of a grant from the Russian Science Foundation No. 23-24-00383, https://rscf.ru/project/23-24-00383 /.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.10.2024. Accepted for publication: 25.11.2024.