JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.
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The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
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The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Medical Radiology and Radiation Safety. 2025. Vol. 70. № 1
DOI:10.33266/1024-6177-2025-70-1-53-59
I.A. Galstian, A.Yu. Bushmanov, F.S. Torubarov, Z.F. Zvereva,
O.V. Shcherbatykh, V.Yu. Nugis, N.A. Metlyaeva, V.I. Pustovoit,
A.S. Umnikov, M.V. Konchalovsky, A.V. Aksenenko, V.V. Korenkov,
L.A. Yunanova, O.G. Kashirina
The Possibilities of Early Diagnosis of Acute Radiation Syndrome Combined with Mechanical Injury
A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
Contact person: I.A. Galstian, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To study the possibilities of using for early diagnosis of acute radiation bone marrow syndrome (ARBMS) combined mechanical injuries (CRMI) symptoms of the primary reaction to radiation (time of onset of nausea and vomiting, the multiplicity of the vomiting), as well as to assess the depth of absolute lymphopenia during the first week after radiation exposure.
Material and methods: 1. Comparative analysis of the literature data on the early symptoms of traumatic brain injury (TBI) and previously published own data on the primary reaction to radiation exposure in acute radiation syndrome (ARS) of varying severity in 134 victims on 04/26/1986 in the Chernobyl accident. 2. Comparative analysis of the dynamics of the absolute number of peripheral blood lymphocytes in 36 patients with mechanical polytrauma (average age – 40.24 ± 4.07 years) and 11 ARS I patients (comparison group 1, average age – 30.00 ± 2.01 years), as well as 15 ARS II patients (comparison group 2, average age – 28.47 ± 2.03 years). Statistical processing of the material is the IBM SPSS Statistics.23 software package, the Kraskal‒Wallis criteria and the Mann‒Whitney U-criterion for independent samples. The results obtained were considered statistically reliable at p <0.05.
Results: 1. Upon admission of a patient with suspected TBI within the framework of CRMI, who has nausea and vomiting, is unconscious and has damage to the skin of the head, dyspeptic syndrome cannot be considered only as a manifestation of the primary reaction to radiation. In the absence of suspicion of TBI, with clear consciousness and intact skin, nausea and vomiting can be used to predict the severity of developing ARBMS. 2. Analysis of the dynamics of peripheral blood lymphocytes in 15 (41.7 %) patients with polytrauma revealed absolute lymphopenia during the first week after mechanical exposure. At the same time, the depth of absolute lymphopenia in trauma without exposure to ionizing radiation at the time when it is usually examined and the severity of ARBMS is determined in individual patients corresponds to the indicators characteristic of ARS I and ARS II (can reach 0.3 × 109/l).
Conclusions: The use of methods for early diagnosis of the severity of ARBMS will have some features in CRMI. The use of criteria for the primary reaction to radiation to diagnose the severity of developing ARBMS can be recommended only if the patient has no obvious signs of TBI: consciousness is preserved, there are no signs of mechanical trauma in the head area (hematomas, abrasions, open wounds, bone fractures). In 42 % of patients with mechanical polytrauma, posttraumatic fever may be detected during the first week of follow-up post-traumatic absolute lymphopenia in combination with post-traumatic absolute lymphopenia can lead to an overestimation of the severity of developing ARBMS. The final decision on the prognosis of the severity of ARBMS, as well as CRMI in general and patient management tactics should be made only after evaluating the absorbed dose by cytogenetic method.
Keywords: combined radiation-mechanical injury, acute radiation bone marrow syndrome, traumatic brain injury, biodosimetry, early diagnosis, primary reaction to radiation, lymphocyte test
For citation: Galstian IA, Bushmanov AYu, Torubarov FS, Zvereva ZF, Shcherbatykh OV, Nugis VYu, Metlyaeva NA, Pustovoit VI, Umnikov AS, Konchalovsky MV, Aksenenko AV, Korenkov VV, Yunanova LA, Kashirina OG. The Possibilities of Early Diagnosis of Acute Radiation Syndrome Combined with Mechanical Injury. Medical Radiology and Radiation Safety. 2025;70(1):53–59. (In Russian). DOI:10.33266/1024-6177-2025-70-1-53-59
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.10.2024. Accepted for publication: 25.11.2024.