JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
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The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
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The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Medical Radiology and Radiation Safety. 2025. Vol. 70. № 4
DOI:10.33266/1024-6177-2025-70-4-33-38
M.V. Merkulov, T.A. Astrelina, D.Yu. Usupzhanova, V.A. Brunchukov, I.V. Kobzeva, Yu.B. Suchkova, N.P. Iashin, O.G. Mikhadarkina, V.A. Nikitina, T.F. Malivanova, E.A. Dubova, S.V. Lishchuk, K.A. Pavlov, O.F. Serova
Evaluation of the Use of a Modified Hydrogel in the Treatment
of Local Radiation-Induced Skin Injures of Laboratory Animals
A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
Contact person: T.A. Astrelina, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Abstract
Introduction: Improving existing and developing new methods for treating local radiation injuries (LRI) of the skin is very important. One of the promising areas in this area is the development of preparations – hydrogels (H) with high regenerative potential, obtained from lyophilisates of decellularized biological tissues (LDT). Due to the multicomponent composition and the presence of such connective tissue components as collagen, laminin, fibronectin, elastin, as well as growth factors, such hydrogels stimulate cellular migration and adhesion, and also maintain their viability and functional activity in the wound bed. To improve the ease of use (improving the mechanical properties of the drug), as well as slowing down the biodegradation process, H-LDT preparations are modified, in particular, by the method of chemical cross-linking with genipin (GNP).
Objective: To evaluate the effectiveness of using a modified hydrogel preparation in the treatment of local radiation skin lesions in laboratory animals.
Material and methods: Local radiation injuries were modeled in 15 laboratory animals (male Wistar rats, average weight 225.0±25.0 g) using an LNK-268-PS X-ray machine. MLP treatment was performed with a hydrogel from lyophilisate of decellularized human tissues (H-LDT), obtained by a modified method of dry-cleaning cross-linking with genipin (GNP: 0.2 mM) on days 28–32, 35, 42 after irradiation. The animals were divided into 3 groups (5 animals in each) depending on the type of therapy: control group without therapy; H-LDT group; H-LDT+GNP group. Observation of laboratory animals was carried out up to 119 days with planimetric and histological examination (hematoxylin and eosin staining) of the course of the wound process of MLP.
Results: Planimetric studies have shown that the area (S) of the open wound surface (OWS) decreased by 30 % of the total S lesion in the experimental groups of animals (Н-LDH and H-LDH+GNP) on day 56 compared to the control group – on day 70. On day 119 of observation, healing of the LRI and the absence of OWS were noted in 40 % of animals in the H-LDT group. In the H-LDH+ GNP group, from day 28 to day 119 of observation, a decrease in S OWS by 6.15 times was noted compared to the control group of animals – by 3.49 times. In the H-LDT group, the results of histological studies demonstrated weak inflammatory infiltration, healing of the LRI and the absence of inflammatory infiltration and necrosis zone, the presence of single hair follicles.
Conclusion: Thus, the present study showed that hydrogel preparations from lyophilisate of decellularized human tissues and hydrogel modified with genipin have a positive effect on the dynamics of the course of the wound process of LRI in laboratory animals, no irritating effect on the skin was detected.
Keywords: modified hydrogel, localized radiogenic lesions, therapeutic potential, biomaterials
For citation: Merkulov MV, Astrelina TA, Usupzhanova DYu, Brunchukov VA, Kobzeva IV, Suchkova YuB, Iashin NP, Mikhadarkina OG, Nikitina VA, Malivanova TF, Dubova EA, Lishchuk SV, Pavlov KA, Serova OF. Evaluation of the Use of a Modified Hydrogel in the Treatment of Local Radiation-Induced Skin Injures of Laboratory Animals. Medical Radiology and Radiation Safety. 2025;70(4):33–38.
(In Russian). DOI:10.33266/1024-6177-2025-70-4-33-38
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PDF (RUS) Full-text article (in Russian)
Conflict of interest. The authors declare no conflict of interest.
Financing. The study had no sponsorship.
Contribution. Article was prepared with equal participation of the authors.
Article received: 20.03.2025. Accepted for publication: 25.04.2025.