JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.
Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.
The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.
The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Medical Radiology and Radiation Safety. 2016. Vol. 61. No. 4. P. 35-42
RADIATION SAFETY
V.Yu. Nugis, A.Yu. Bushmanov, H.E. Zapadinskaya, M.G. Kozlova, O.A. Tyhonova
Cytogenetic Studies 28-29 Years After the Accident at the Chernobyl NPP
A.I. Burnasyan Federal Medical Biophysical Center of FMBA, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: Cytogenetic examination of liquidators who worked in different years and residents of different contaminated areas nearly 30 years after the accident at the Chernobyl nuclear power plant.
Material and methods: The cytogenetic studies were carried out with the use of peripheral blood lymphocyte cultures. The majority of individuals were examined with the help of FISH- and classical methods of staining chromosomes in parallel.
Results: In general the frequencies of FISH-detected translocations were above background levels in 15 (out of 58 people): 12 out of 41 liquidators and 3 out of 17 residents of contaminated territories. The single highly aberrant cells contained mostly unstable chromosome aberrations were detected by FISH-analysis in 9 examined individuals. The presence or absence of such cells was not associated with the availability of an estimated dose cytogenetically. The analysis of the data obtained the classical method showed that the overall frequency of chromosome rearrangements and the frequency of chromosome aberrations - indicators of radiation exposure - did not exceed the background values of the examined persons individually.
Conclusion: The obtained cytogenetic data indicate the possibility of cytogenetic dose evaluation in almost 30 years after the radiation accident with the help of FISH-method. The detection of single highly aberrant cells in peripheral blood lymphocyte cultures is characteristic for this contingent that apparently related to the action of alpha-emitting radionuclides.
Key words: chromosome aberrations, peripheral blood, lymphocytes culture, accidental irradiation, the accident at the Chernobyl NPP
REFERENCES
- Pyatkin E.K., Nugis V.Yu., Chirkov A.A. Otsenka pogloshchennoi dozy po rezul'tatam tsitogeneticheskikh issledovanii kul'tur limfotsitov u postradavshikh pri avarii na Chernobyl'skoi AES. Med. radiol. 1989. Vol. 34. No. 6. P. 52-57. (In Russ.).
- Bochkov N.P., Katosova L.D., Sapacheva V.A. et al. Tsitogeneticheskii analiz limfotsitov perifericheskoi krovi u prozhivayushchikh v zagryaznennykh radionuklidami raionakh Kaluzhskoi oblasti. Med. radiol. 1991. Vol. 36, 1. P. 50-52. (In Russ.).
- Vorobtsova I.E., Kolyubaeva S.N., Vorob'eva M.V. et al. Tsitogeneticheskaya kharakteristika detei, postradavshikh v rezul'tate avarii na Chernobyl'skoi AES. Med. radiol. 1993. Vol. 38. No. 10. P. 25-28. (In Russ.).
- Vorobtsova I.E., Mikhel'son V.M., Vorob'eva M.V. et al. Rezul'taty tsitogeneticheskogo obsledovaniya likvidatorov posledstvii avarii na ChAES, provedennogo v raznye gody. Radiats. biologiya. 1994. Vol. 34. No. 6. P. 798-803. (In Russ.).
- Domracheva E.V., Klevezal' G.A., Nechai V.V. et al. Individual'nye dozy oblucheniya, opredelennye dvumya metodami biologicheskoi dozimetrii u zhitelei Chernobyl'skogo regiona i uchastnikov likvidatsii avarii. Gematol. i transfuziol. Vol. 36. No. 12. P. 18-20. (In Russ.).
- Zainullin V.G., Borodkin P.A., Chernyak S.I. et al. Rezul'taty tsitogeneticheskogo obsledovaniya lits, prinimavshikh uchastie v likvidatsii avarii na Chernobyl'skoi AES. Radiobiologiya. Vol. 32. No. 5. P. 668-672. (In Russ.).
- Pilinskaya M.A., Shemetun A.M., Dybskii S.S. et al. Tsitogeneticheskii effekt v limfotsitakh perifericheskoi krovi kak indikator deistviya na cheloveka faktorov Chernobyl'skoi avarii. Radiobiologiya. 1992. Vol. 32. No. 6. P. 632-639. (In Russ.).
- Khandogina E.K., Ageikin V.A., Zvereva S.V. et al. Tsitogeneticheskoe obsledovanie razlichnykh grupp detei, prozhivayushchikh v raionakh Bryanskoi oblasti, zagryaznennykh v rezul'tate Chernobyl'skoi avarii. Radiats. biologiya. 1995. Vol. 35. No. 5. P. 618-625. (In Russ.).
- Khvostunov I.K., Sevan'kaev A.V., Mikhailova G.F. et al. Rol' tsitogeneticheskogo obsledovaniya dlya otsenki posledstvii nekontroliruemogo vozdeistviya radiatsii na cheloveka. V sb.: «Meditsinskie radiologicheskie posledstviya Chernobylya: prognoz i fakticheskie dannye spustya 30 let». V.K. Ivanova (ed.), A.D. Kaprina. Moscow: GEOS. 2015. P. 93-119. (In Russ.).
- Cytogenetic Dosimetry: Applications in Preparedness for and Response to Radiation Emergencies. Vienna: IAEA. 2011. 245 p.
- Vorobtsova I.E., Bogomazova A.N. Stabil'nye khromosomnye aberratsii v limfotsitakh perifericheskoi krovi lits, postradavshikh v rezul'tate avarii na ChAES. Radiats. biologiya. Radioekologiya. 1995. Vol. 35. No. 5. P. 636-640. (In Russ.).
- Sevan'kaev A.V., Mikhailova G.F., Potetnya O.I. et al. Rezul'taty dinamicheskogo tsitogeneticheskogo nablyudeniya za det'mi i podrostkami, prozhivayushchimi na radioaktivno-zagryaznennykh territoriyakh posle Chernobyl'skoi avarii. Radiats. biologiya. 2005. Vol. 45. No. 1. P. 5-15. (In Russ.).
- Snigireva G.P., Shevchenko V.A., Novitskaya N.N. Ispol'zovanie FISH metoda dlya rekonstruktsii pogloshchennykh doz, poluchennykh uchastnikami likvidatsii avarii na Chernobyl'skoi AES. Radiats. biologiya. Radioekologiya. 1995. Vol. 35. No. 5. P. 654-661. (In Russ.).
- Shevchenko V.A., Snigireva G.P. Znachimost' tsitogeneticheskogo obsledovaniya dlya otsenki posledstvii Chernobyl'skoi katastrofy. Radiats. biologiya. Radioekologiya. 2006. Vol. 46. No. 2. P. 133-139. (In Russ.).
- Maznyk N.A., Vinnikov V.A. Retrospective cytogenetic biodosimetry using fluorescence in situ hybridization (FISH) technique in persons exposed to radiation due to the Chornobyl accident. Ukraïns'kii radiologichnii zhurnal. 2005. Vol. 13. No. 1. P. 66-72.
- Nugis V.Yu., Kozlova M.G. Tsitogeneticheskie issledovaniya v dvukh situatsiyakh obnaruzheniya nekontroliruemykh istochnikov ioniziruyushchego izlucheniya. Medical Radiology and Radiation Safety. 2015. Vol. 60. No. 2. P. 37-46. (In Russ.).
- Lucas J.N., Awa A., Straume T. et al. Rapid translocation frequency analysis in human decades after exposure to ionizing radiation. Int. J. Radiat. Biol. 1992. Vol. 62. No. 1. P. 53-63.
- Mendelsohn M.L., Mayall B.H., Bogart E. et al. DNA content and DNA-based centromeric index of 24 human chromosomes. Science. 1973. Vol. 179. No. 78. P. 1126-1129.
- Snigireva G.P., Bogomazova A.N., Novitskaya N.N. et al. Biologicheskaya indikatsiya radiatsionnogo vozdeistviya na organizm cheloveka s ispol'zovaniem tsitogeneticheskikh metodov. Meditsinskaya tekhnologiya No.FS-2007/015-U. Moscow: 2007. 29 p. (In Russ.).
- Vorobtsova I.E., Semenov A.V. Vozrastnaya dinamika chastoty spontannykh i indutsirovannykh in vitro khromosomnykh aberratsii v limfotsitakh krovi cheloveka pri estestvennom i luchevom starenii. Radiats. biologiya. 2010. Vol. 50. No. 3. P. 253-258. (In Russ.).
- Sigurdson A.J., Ha M., Hauptmann M. et al. International study of factors affecting human chromosome translocations. Mutat. Res. 2008. Vol. 652. No. 2. P. 112-121.
- Whitehouse C.A., Edwards A.A., Tawn E.J. et al. Translocation yields in peripheral blood lymphocytes from control populations. Int. J. Radiat. Biol. 2005. Vol. 81. No. 2. P. 139-145.
- Bakaeva O.A. Neobkhodimost' ispol'zovaniya popravki Ietsa v kriterii χ2 proverki nezavisimosti kachestvennykh peremennykh. Nauchnye issledovaniya i ikh prakticheskoe primenenie. Sovremennoe sostoyanie i puti razvitiya 2012: Sb. nauch. trudov SWorld Mezhdunarodnoi nauchno-prakticheskoi konferentsii. Odessa: Publ. KUPRIENKO. 2012. Vol. 2. Vyp. 3. P. 82-83. (In Russ.).
- Savage J.K. Classification and relationships of induced chromosomal structural changes. J. Medical Genetic. 1976. Vol. 13. No. 2. P. 103-122.
- Salassidis K., Georgiadou-Schumacher V., Braselmann H. et al. Chromosome painting in highly irradiated Chernobyl victims: a follow-up study to evaluate the stability of symmetrical translocations and the influence of clonal aberrations for retrospective dose estimation. Int. J. Radiat. Biol. 1995. Vol. 68. No. 3. P. 257-262.
- Kudryashov Yu.B. Radiatsionnaya biofizika (ioniziruyushchie izlucheniya). Pod red. V.K. Mazurika, M.F. Lomanova. Moscow: FIZMATLIT. 448 p.
- Edwards A.A., Lindholm C., Darroudi F. et al. Review of translocations detected by FISH for retrospective biological dosimetry application. Radiat. Protect. Dosim. 2005. Vol. 113. No. 4. P. 396-402.
- Sevan'kaev A.V., Khvostunov I.K., Snigireva G.P. et al. Sravnitel'nyi analiz rezul'tatov tsitogeneticheskikh obsledovanii kontrol'nykh grupp lits v razlichnykh otechestvennykh laboratoriyakh. Radiats. biologiya. 2013. Vol. 53. No. 1. P. 5-24. (In Russ.).
For citation: Nugis VYu, Bushmanov AYu, Zapadinskaya HE, Kozlova MG, Tyhonova OA. Cytogenetic Studies 28-29 Years after the Accident at the Chernobyl NPP. Medical Radiology and Radiation Safety. 2016;61(4):35-42. Russian.
PDF (RUS) Full-text article (in Russian)