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The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.

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Medical Radiology and Radiation Safety. 2016. Vol. 61. No. 4. P. 68-75

REVIEW

I.A. Znamenskiy1,2, A.K. Kondakov1,2, V.V. Mil’kin1, D.Ju. Mosin1, A.V. Grechko1

Positron Emission Tomography with Oxygen-15 in Neurological Practice. Part 2. Clinical Application

1. Hospital for incurable patients -Scientific and Medical Rehabilitation Center, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. N.I. Pirogov Russian National Research Medical University, Moscow, Russia.

ABSTRACT

Purpose: To analyze clinical application of positron-emission tomography with radiopharmaceuticals based on oxygen-15 and to determine the field of its application.

Material and methods: The review of sources, selected from international bibliographic databases.

Results: It is shown that PET with radiopharmaceuticals based on oxygen-15 leads to deep exploration of pathophysiologic basis of a number of brain diseases, among which is ischemic stroke which occupies an important place. Furthermore, the review presents clinical application of PET for chronic cerebrovascular diseases and as a gold standard for validation of other neuroimaging modalities.

Conclusion: PET with radiopharmaceuticals based on oxygen-15 is the only one direct validated method of measurement of a number of quantities characterizing the perfusion and functional capacity of the brain. It may be used in the evaluation of penumbra, quality control of treatment for chronic cerebrovascular diseases and in research. Wide application of this method is prevented by a need of implementation of a large number of costly technical measures.

Key words: positron emission tomography, 15O, perfusion, brain, review

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For citation: Znamenskiy IA, Kondakov AK, Milkin VV, Mosin DJu, Grechko AV. Positron Emission Tomography with Oxygen-15 in Neurological Practice. Part 2. Clinical Application. Medical Radiology and Radiation Safety. 2016;61(4):68-75. Russian.

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