SCIENTIFIC AND INFORMATION-ANALYTICAL MAGAZINE

ISSN 1024-6177 (Print), ISSN 2618-9615 (Online)

JOURNAL DESCRIPTION

The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.

Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.

Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.

The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.

Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.

The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.

Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.

The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.

Medical Radiology and Radiation Safety. 2015. Vol. 60. No. 5. P. 59-73

REVIEW

E.A. Dunaeva1, A.V. Boyko1, L.V. Demidova1, L.Z. Velher2, L.I. Korobkova2, A.U. Korobkova2, O.B. Dubovetskaya1, T.A. Teleous1

Conservative Methods of Prevention and Treatment of Radiation Complications in Patients with Malignant Neoplasms of Female Genital Organs

1. P.A. Herzen Research Oncological Institute, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. A.I. Evdokimov Moscow Stage University of Medicine and Dentistry, Moscow, Russia

CONTENTS

Radiation therapy of malignant tumors of the genitals, even with the use of modern equipment and radiotherapy capabilities, as well as, dosimetry planning leads to the development of pathological changes in the mucosa of the rectum, bladder and vagina in 20-80 % of patients. The main factors influenced on the occurrence and severity of radiation damage are: the value of single and total focal dose, the dose fractionation regimen, method of irradiation (remote, intracavitary, combined), the number of exposures (2, 4, 6 patch reference technique for remote RT), co-morbidities of annexa (rectosigmoid colon, bladder, vagina), radiomodifications (chemotherapy, hyperthermia), surgery on the pelvic organs and the initial state of the organism. In the treatment of local radiation damage generally used approach includes methods of general and local feedback. Among conservative methods of treatment of local radiation injuries physical impact factors, such as low-intensity laser radiation (LLLT) have recently become widely used. Creating optimal combinations of drugs (in the form of ointments, gels, sprays, suppositories, etc.) having a therapeutic effect on wound process are recognized as of promising. The advent of technology aimed (targeted) drug delivery using Kolegel gels suggests a significant impact on the state of tissues within the irradiation zone. Application of these hydrogel materials allowed marking good tolerance, high efficiency in the prevention of radiation reactions (as compared to standard procedures).

Key words: female sexual organs, conservative treatment, radiation complications, radiation rectitis, radiation cystitis, radiation mucousitis, review

REFERENCES

  1. Kaprin A.D., Starinskii V.V., Petrova G.V. Sostoyanie onkologicheskoi pomoshchi naseleniyu Rossii v 2013 godu. Moscow: MNIOI im. A. Gertsena. 2014. 235 p. (In Russ.).
  2. Beller U., Vaisonneuve P. et al. Carcinoma of the vulva. Int. J. Gynecol. Abstet. 25th Annual Report on the Results of Treatment in Gynecologic Cancer. 2003. Vol. 83. P. 7-27.
  3. Van der Zee J., Kleynen C.E., Nuyttens J.J., Ansink A.C. Hyperthermia to improve results in vaginal cancer. Radiother. Oncol.. 2008. Vol. 88. No. 2. P. 286-287.
  4. Halperin C., Perez A., Brady W. Radiation Oncology. 2010. 865 p.
  5. Kanaev S.V., Baranov S.B. Opyt ispol'zovaniya preparata «Tantum rosa» pri profilaktike i lechenii luchevykh rektitov i vaginitov u bol'nykh rakom matki i vlagalishcha. Voprosy onkologii. 2003. No. 2. P. 224-226. (In Russ.).
  6. Korolev S.V. Luchevaya diagnostika i kompleksnoe lechenie luchevykh tsistitov u onkologicheskikh bol'nykh. Moscow: diss. kand. med. nauk. 2009. 116 p. (In Russ.).
  7. Van Limbergen E. Nauchno-obosnovannye rekomendatsii po provedeniyu luchevoi terapii pri rake sheiki matki. Materialy Evropeiskoi shkoly onkologii «Sovremennye aspekty onkoginekologii». Moscow. 2009. P. 11-27.
  8. Kaprin A.D., Pasov V.V., Korolev S.V., Terekhov O.V. Prichiny razvitiya luchevykh tsistitov u bol'nykh, perenesshikh luchevuyu terapiyu po povodu zlokachestvennykh novoobrazovanii malogo taza. Onkourologiya. 2009. No. 1. P. 39-42. (In Russ.).
  9. Pasov V.V., Kurpesheva A.K., Terekhov O.V. Luchevye povrezhdeniya mochevogo puzyrya i kishechnika. V kn.: «Immunoterapiya. Rukovodstvo dlya vrachei». In: R.M. Khaitova, R.I. Atullakhanova (eds.). Moscow: GEOTAR-Media. 2011. P. 541-559. (In Russ.).
  10. Tararova E. A. Patogeneticheskie aspekty luchevogo tsistita. Moscow: diss. dokt. med. nauk. 2011. 96 p. (In Russ.).
  11. Zharikov A.A., Terekhov O.V. Onkologicheskaya zabolevaemost' organov malogo taza, luchevye povrezhdeniya i ikh diagnostika (obzor literatury). Radiatsiya i risk. 2013. Vol. 22. No. 3. P. 57-64. (In Russ.).
  12. Bardychev M.S. Luchevye povrezhdeniya. V kn.: «Luchevaya terapiya zlokachestvennykh novoobrazovanii». In: S. Kiselevoi (ed.). Moscow: Meditsina. 1996. P. 437-459. (In Russ.).
  13. Gabelov A.A., Kholin V.V., Lubenets E.N. Pozdnie luchevye povrezhdeniya pryamoi kishki. Metod. rekomendatsii Minzdrava SSSR. Leningrad. 1978. 18 p. (In Russ.).
  14. Stolyarova I.V., Vinokurov V.L. Problemy bol'nykh posle lecheniya raka sheiki matki (profilaktika i lechenie oslozhnenii). Prakticheskaya onkologiya. 2002. Vol. 3. No. 3. P. 220-227. (In Russ.).
  15. Skryabin G.N., Aleksandrov V.P., Koren'kov D.G., Nazarov T.N. Tsistity. Uchebnoe posobie. Petersburg. 2006. 127 p. (In Russ.).
  16. Chassagne D., Sismondi P., Horiot J.C. et al. A glossary for reporting complications of treatment in gynecological cancers. Radiother. Oncol. 1993. Vol. 26. P. 195-202.
  17. Cox J.D., Stetz J., Pajak T.F. Toxicity of the Radiation Therapy Oncology Group (RTO G) and the European Organization for Research And Treatment Of Cancer (EORTC). Int. J. Radiat. Oncol. Biol. Phys. 1995. Vol. 31. No. 5. P. 1341-1346.
  18. LENT SOMA tables. Radiother.Oncol. 1995. Vol. 28. P. 17-60.
  19. Luchevaya terapiya: uchebnik. T. 2. In: G.E. Trufanova, M.A. Asaturyana, G.M. Zharinova (eds.). Moscow: «GEOTAR-Media». 2010. 192 p. (In Russ.).
  20. Deehan C., Donogyue J.A. Biological equivalence of LDR and HDR brachytherapy. In Brachytherapy from Radium to Optimization. Ed. R.F. Mould, J.J. Battermann, A.A. Martinez, B.L. Spaiser. Netherlands. 1994. P. 19-37.
  21. Perez C.A. Radiation therapy morbility in carcinoma of uterine cervix: dosimetric and clinical correlation. Int. J. Radiation Oncol. Biol. Phys. 1999. Vol. 44. No. 4. P. 855-866.
  22. Demidova L.V. Radiomodifikatsiya v sochetannoi luchevoi terapii raka sheiki matki s ispol'zovaniem netraditsionnykh rezhimov fraktsionirovaniya i lekarstvennykh preparatov. Moscow: diss. dokt. med. nauk. 2006, 341 p. (In Russ.).
  23. Demidova L.V., Dunaeva E.A., Boiko A.V. et al. Oslozhneniya luchevoi terapii pri kombinirovannom lechenii bol'nykh rakom tela matki I stadii. Vestnik RONTs im. N.N. Blokhina RAMN. 2011. Vol. 22. No. 4. P. 39-45. (In Russ.).
  24. Pötter R., Haie-Meder C., Van Limbergen E. et al. Radiother. Oncol.. 2006. Vol. 78. P. 67-77.
  25. Ivanitskaya V.I. Oslozhneniya luchevoi terapii u onkologicheskikh bol'nykh. Kiev. 1989. 184 p. (In Russ.).
  26. Clark B., Souhami L., Roman T. et al. The prediction of late rectal complications in patients treated with high dose-rate brachytherapy for carcinoma of the cervix. Int. J. Radiat. Oncol. Biol. Phys. 1997. Vol. 38. No. 5. P. 989-993.
  27. Pan'shin G.A., Rybakov Yu.N., Bliznyukov O.P., Zotov V.K. K voprosu o mestnykh luchevykh povrezhdeniyakh pryamoi kishki u bol'nykh rakom sheiki matki (obzor). Vestnik RNTsRR. 2010. Vol. 2. No. 10. (In Russ.).
  28. Bardychev M.S., Katsalap S.N., Kurpesheva A.K. Diagnostika i lechenie mestnykh luchevykh povrezhdenii. Medical Radiology and Radiation Safety. 1992. Vol. 37. No. 11. P. 12-14. (In Russ.).
  29. Granov A.M., Vinokurov V.L. Luchevaya terapiya v onkoginekologii i onkourologii. St.Petersburg, Foliant. 2002. 352 p. (In Russ.).
  30. Bukharkin B.V., Davydov M.I., Karyakin O.B. et al. Klinicheskaya onkourologiya. Moscow. 2003. P. 24-26. (In Russ.).
  31. Rusanov A.O. Planirovanie vnutripolostnogo oblucheniya i prognozirovanie rezul'tatov luchevoi terapii bol'nykh rakom sheiki matki. Moscow: diss. kand. med. nauk. 2003. 160 p. (In Russ.).
  32. Maksimov S.Ya., Guseinov K.D. Kombinirovannoe lechenie raka sheiki matki. V kn.: «Prakticheskaya onkologiya: izbrannye lektsii». In S.A. Tyulyandina i V.M. Moiseenko (eds.). Saint Petersburg: Tsentr TOMM. 2004. P. 678-686. (In Russ.).
  33. Suwinski R., Sowa A., Rutkowski T. et al. Time factor in postoperative radiotherapy: a multivariate locoregional control analysis in 868 patients. Int. J. Radiat. Oncol. Phys. 2003. Vol. 56. No. 2. P. 399-412.
  34. Klimenko K.A., Tsallagova Z.S. Luchevye rektity pri kompleksnom lechenii raka organov malogo taza (obzor literatury). Vestnik RRNTsRR. 2014. Vol. 4. No. 14. Elektronnyi resurs. Available from: http://vestnik.rncrr.ru/vestnik/v14/papers/klimenko_14.htm. (In Russ.).
  35. Dawson L.A., Sharpe M.B. Image-guided radiotherapy: rationale, benefits, and limitations. Lancet. 2006. Vol. 17. P. 848-859.
  36. Jhingran A., Eifel P., Ramirez P. Treatment of Locally Advanced Cervical Cancer. In: Gynecological Cancer. Ed. P. Eifel, D. Gershenson, J. Kavanagh. Springer. 2006. P. 87-125.
  37. Boiko A.V., Chernichenko A.V., Dar'yalova S.L. et al. Netraditsionnoe fraktsionirovanie dozy. Lektsiya. Materialy V Rossiiskoi onkologicheskoi konferentsii. 2001. P. 120-122. (In Russ.).
  38. Jacob R.A., Burri B.J. Oxidative damage and defence. Amer. J. Clin. Nutr. 1996. Vol. 63. No. 6. P. 995-990.
  39. V. Boiko, L.V. Demidova, E.A. Dunaeva, et al. Khimioluchevaya terapiya bol'nykh mestno-rasprostranennym rakom sheiki matki. Meditsinskaya tekhnologiya. Moscow. 2010. 13 p. (In Russ.).
  40. Sergeeva T.V. Modifikatsiya khimioluchevogo lecheniya zlokachestvennykh novoobrazovanii preparatami antioksidantnogo deistviya. Moscow: diss. kand. med. nauk. 1999. 157 p. (In Russ.).
  41. Zharikov G.M., Vinokurov V.L., Zaikin G.V. Luchevye povrezhdeniya pryamoi kishki i mochevogo puzyrya u bol'nykh rakom sheiki matki. Mir Meditsiny. 2000. No. 7-8. Available from: http://medi.ru/doc/8500710.htm. (In Russ.).
  42. Bardychev M.S. Lechenie mestnykh luchevykh povrezhdenii. Lechashchii vrach. 2003. No. 5. P. 78-79. (In Russ.).
  43. Hovdenak N., Fajardo L.F., Hauer-Jensen M. Acute radiation proctitis: a sequential clinicopathologic study during pelvic radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 2000. Vol. 48. P. 1111-1117.
  44. Khoseva E.N. Klinicheskie varianty, osobennosti techeniya i differentsirovannaya terapiya rannikh luchevykh reaktsii i povrezhdenii kozhi. Ekaterinburg: diss. kand. med. nauk. 2006. 116 p. (In Russ.).
  45. Goncharik I.I. Radiatsionnyi (luchevoi) kolit i enterit. Voennaya meditsina. 2010. No. 4. P. 119-121. (In Russ.).
  46. Roitberg G.E., Strutynskii A.V. Vnutrennie bolezni. Sistema organov pishchevareniya: uchebnoe posobie. Moscow: Med-press-inform. 2011. 560 p. (In Russ.).
  47. Burakovskaya V.A. Radiatsionnye (luchevye) porazheniya kishechnika. Gastroenterologiya. Sain Petersburg. 2013. No. 3-4. P. 18-24. (In Russ.).
  48. Chuikina N.A., Matyakin G.G., Chuprik-Malinovskaya T.P. et al. Aktovegin v profilaktike i lechenii luchevykh reaktsii i oslozhnenii u onkologicheskikh bol'nykh. Moscow. 1999, 56 p. (In Russ.).
  49. Bardychev M.S., Terekhov O.V., Belaya N.S. Terapevticheskaya effektivnost' gepona v lechenii luchevykh tsistitov. Lechashchii vrach. 2003. No. 10. P. 61-62. (In Russ.).
  50. Kan Ya.D. Urologicheskie oslozhneniya luchevoi terapii zlokachestvennykh novoobrazovanii organov taza. Moscow: diss. dokt. med. nauk. 1989. 233 p. (In Russ.).
  51. Kargaeva Z.S. Primenenie immobilizirovannogo tripsina dlya profilaktiki i lecheniya luchevykh reaktsii i oslozhnenii u onkoginekologicheskikh bol'nykh. Moscow: diss. kand. med. nauk. 2000, 130 p. (In Russ.).
  52. Terekhov O.V., Pasov V.V. Lechenie pozdnikh luchevykh povrezhdenii mochevogo puzyrya. Effektivnaya farmakoterapiya. Urologiya i nefrologiya. 2014. Vol. 32. No. 3. Available from: http://umedp.ru/articles/uro_3_2014/lechenie_pozdnikh_luchevykh_povrezhdeniy_mohevogo_puzyrya.html. (In Russ.).
  53. Zaderin V.P., Polyanichko M.F. Terapiya pozdnikh oslozhnenii luchevogo lecheniya bol'nykh zlokachestvennymi novoobrazovaniyami. Rostov-on-Don. 1985. P. 13-19. (In Russ.).
  54. Vel'sher L.Z., Matyakin E.G., Duditskaya T.K. Onkologiya. Moscow. 2009. 510 p. (In Russ.).
  55. Fil'kova E.M., Poleskova O.A., Kochnova Yu.S. et al. Sposoby povysheniya effektivnosti luchevoi terapii. Patent na izobretenie. 1997. 9 p. (In Russ.).
  56. Kharchenko V.P., Pan'shin G.A., Voznyi E.K. et al. Sposob profilaktiki mestnykh luchevykh reaktsii. Patent na izobretenie. 2004. 11 p. (In Russ.).
  57. Shipilova A.N., Titova V.A., Kreinina Yu.M. et al. Sistemnaya i lokal'naya ozonoterapiya v profilaktike oslozhnenii mnogokomponentnogo lecheniya zlokachestvennykh opukholei razlichnoi lokalizatsii. Vestnik RNTsRR. 2006. P. 7-14. (In Russ.).
  58. Zalesskii V.N. Molekulyarnye mekhanizmy lazernoi biostimulyatsii. Sb. nauchnykh trudov k 50-letiyu lazernoi meditsiny. Ukraina. 2010. P. 307-401. (In Russ.).
  59. Kabisov R.K., Boiko A.V., Sokolov V.V. et al. Sposob lecheniya onkologicheskikh bol'nykh. Patent na izobretenie RU (11) 2161054 (13) C2. Published: 2000.12.27. (In Russ.).
  60. Kaplina E.N., Vainberg Yu.P. Derinat - prirodnyi immunomodulyator dlya detei i vzroslykh. Ed. 3rd, corr. and suppl. Moscow: Nauchnaya kniga. 2007. 240 p. (In Russ.).
  61. Kurpesheva A.K., Pasov V.V., Terekhov O.V. et al. Otsenka effektivnosti lecheniya i perenosimosti gidrogelevykh materialov na osnove al'ginata natriya s derinatom (dezoksiribonukleatom natriya) «Koleteks-gel'-DNK» i s derinatom i lidokainom «Koleteks-gel'-DNK-L». Obninsk. 2007. P. 31-37. (In Russ.).
  62. Danilova M.A. Razrabotka tekhnologii polucheniya lechebnykh tekstil'nykh i gidrogelevykh materialov dlya luchevoi terapii onkologicheskikh zabolevanii. Moscow: diss. kand. tekhn. nauk. 2008. 202 p. (In Russ.).
  63. Korytova L.I., Oltarzhevskaya N.D., Sokurenko V.P. et al. Effektivnost' primeneniya nanogidrogelevykh materialov «Koleteks-gel'-DNK», «Koleteks-gel'-DNK-L». Bioterap. Journal. 2009. Vol. 8. No. 1. P. 20
  64. Napravlennaya dostavka lekarstvennykh preparatov pri lechenii onkologicheskikh bol'nykh. In A.V. Boiko, L.I. Korytovoi, N.D. Oltarzhevskoi (eds.). Moscow: MK. 2013. 200 p. (In Russ.).

For citation: Dunaeva EA, Boyko AV, Demidova LV, Velher LZ, Korobkova LI, Korobkova AU, Dubovetskaya OB, Teleous TA. Conservative Methods of Prevention and Treatment of Radiation Complications in Patients with Malignant Neoplasms of Female Genital Organs. Medical Radiology and Radiation Safety. 2015;60(5):59-73. Russian.

PDF (RUS) Full-text article (in Russian)

Contact Information

 

46, Zhivopisnaya st., 123098, Moscow, Russia Phone: +7 (499) 190-95-51. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Journal location

Attendance

2939831
Today
Yesterday
This week
Last week
This month
Last month
For all time
957
2306
17069
33458
38127
113593
2939831
Forecast today
2232

Your IP:216.73.216.100
Visitor Counter

© Журнал "Медицинская радиология и радиационная безопасность" 2020г.

Яндекс.Метрика

Наверх