JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
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Medical Radiology and Radiation Safety. 2015. Vol. 60. No. 1. P. 26-32
RADIATION BIOLOGY
I.A. Galstyan, N.M. Nadejina, M.G. Levadnaya, A.V. Aksenenko
Ulcer-Cancer of the Skin as an Outcome of Local Radiation Injury
Burnasyan Federal Medical Biophysical Center of FMBA, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To estimate the frequency and risk factors for malignancy of late radiation ulcers as an outcome of the local radiation injuries (LRI).
Material and methods: 217 cases of long-term supervisions on the wound process and late consequences of LRI developed owing acute accidental radiation exposure were analyzed. Four clinical supervisions of skin-cancer are described in details. The review of literature findings on the matter is provided.
Results: Cancer emergence in the area of existing late radiation ulcer is rare outcome of LRI after acute exposure and it is slightly more often at chronic radiation exposure. In Burnazyan FMBC archive there are data about 4 cases (1.8 %) of a cancer in the long existing radiation ulcers development. The average duration of existence of a late radiation ulcer until its malignancy 21.8 ± 3.2 (15-29) years with the average duration of supervision of patients of this whole group about 20 years. Average age of the patients at the moment of development of a neoplasma 60.8 ± 4.9 (48-69) years. As the main localization of LRI at contacts with the isolated sources of ionizing radiation are hands, in 3 of 4 cases the cancer was revealed on hands. Other localizations LRI to data of literature are rarer. Only one the cancer ulcer was found on a forward surface of a hip. Choice method for treatment of cancer ulcer is an active surgery. At our patients recurrence of the tumor wasn’t observed yet.
Conclusions: Possible outcome of late radiation ulcer is an ulcer cancer development. Frequency of a malignancy in the long existing late radiation ulcer 1.8 % that according to literature doesn’t exceed the frequency of tumor development in long existing nonradiation ulcer. This similarity is testified nonspecific pathogenetic mechanism related with vascular disturbances and insufficient immunological control in the LRI. Undoubtedly, the role of almost continuous local use of medicines, including possessing an irritant action is significant as well. Performed plastic surgery in the field of LRI could prevent a malignancy of ulcers and, thereby, improves quality of life and the life forecast.
Key words: local radiation injury, outcomes, late radiation ulcer, cancer, neoplasm
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For citation: Galstyan IA, Nadejina NM, Levadnaya MG, Aksenenko AV. Ulcer-Cancer of the Skin as an Outcome of Local Radiation Injury. Medical Radiology and Radiation Safety. 2015;60(1):26-32. Russian.
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