JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
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The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Medical Radiology and Radiation Safety. 2018. Vol. 63. No. 1. P. 53-56
NUCLEAR MEDICINE
DOI: 10.12737/article_5a85541371b9d7.91570726
The Possibility of Using the Sodium-Fluoride, 18F at Non-Neoplastic Lesions of Bone Tissue (Experimental Study)
N.A. Kostenikov, V.F. Dubrovskaya, O.Yu. Mirolyubova, O.V. Klestova, E.G. Kovan’ko, N.N. Izotova, Yu.R. Ilushchenko, A.A. Stanzhevsky
A.M. Granov Russian Research Center for Radiology and Surgical Technologies, Saint Petersburg, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
N.A. Kostenikov - Head of the Lab., Dr. Sc. Med.; V.F. Dubrovskaya - Leading Researcher, Dr. Sc. Med.; O.Y. Mirolyubova - Senior Researcher, PhD Med.; O.V. Klestova - Senior Researcher, PhD Med.; E.G. Kovan’ko - Senior Researcher, PhD Med.; N.N. Izotova - Technician; Y.R. Ilyushchenko - Researcher; A.A. Stanzhevsky - Deputy Director Dr. Sc. Med.
Abstract
Purpose: To study the possibility of using radiopharmaceutical (RPH) Sodium fluoride, 18F (Na18F) in order to identify the characteristics and dynamics of the development process for a number of non-neoplastic lesions in bone tissue such as fractures and osteoporosis in experimental animals by the method of positron emission tomography (PET).
Material and methods: Two experimental models of pathology of bone tissue in rats were used: fracture and osteoporosis.
The model of osteoporosis was created by intraperitoneal introduction of hydrocortisone during 3 weeks. The study was conducted in 22 days from the onset of the agent introduction. In areas of the chest and sacral sections of the spinal cord in experimental and intact animals we detected the value of uptake of Na18F, as well as indices of tissue density with data of X-ray CT.
In the model of fracture of bones injury struck in the pre-anesthetized rats in the region of the shin. Animals were examined starting from the 3rd day up to the 30th day after the fracture by PET and PET/CT. We detected the value of uptake, the dynamics of Na18F accumulation, as well as indices of densitometry and signs of callus formation with CT examination.
Results: In rats with osteoporosis compared with intact animals observed a 2,5-fold decrease of the bone tissue density in X-ray, whereas the level of metabolic activity in the bones of the PET scan with Na18F was 5.6 times lower than in healthy rats. Therefore, differences in the level of capture of the radiopharmaceutical in PET were significantly more important compared to the ratio of the values of the X-ray of the bone tissue density, determined by CT.
In experiments with shin fracture was noted hyperfixation and increasing rate of Na18F accumulation on PET-scans since the 9th and 30th day from the start of the experiment. It reflects a process of enhancing the metabolism in the injured area. At the same time, a significant increase of densitometric density and visualisation of callus formation in the fracture by CT were detected 3 weeks later, - only by the 30th day after trauma.
Conclusion: The use of Na18F in positron-emission tomography enables to diagnose more early and accurate the nature (osteoporosis) and intensity of processes of the restoration (fracture) in the injured bone tissue as compared to results of computed tomography.
Key words: radiopharmaceutical, positron emission tomography, osteoporosis, bone fracture, animals
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For citation: Kostenikov NA, Dubrovskaya VF, Mirolyubova OYu, Klestova OV, Kovan’ko EG, Izotova NN, Ilushchenko YuR, Stanzhevsky AA. The Possibility of Using the Sodium-Fluoride, 18F at Non-Neoplastic Lesions of Bone Tissue (Experimental Study). Medical Radiology and Radiation Safety. 2018;63(1):53-6. DOI: 10.12737/article_5a85541371b9d7.91570726. Russian.
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