JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.
Brief electronic versions of the Journal have been publicly available since 2005 on the website of the Medical Radiology and Radiation Safety Journal: http://www.medradiol.ru. Since 2011, all issues of the journal as a whole are publicly available, and since 2016 - full-text versions of scientific articles. Since 2005, subscribers can purchase full versions of other articles of any issue only through the National Electronic Library. The editor of the Medical Radiology and Radiation Safety Journal in accordance with the National Electronic Library agreement has been providing the Library with all its production since 2005 until now.
The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
Since 2017 the journal Medical Radiology and Radiation Safety has switched to digital identification of publications, assigning to each article the identifier of the digital object (DOI), which greatly accelerated the search for the location of the article on the Internet. In future it is planned to publish the English-language version of the journal Medical Radiology and Radiation Safety for its development. In order to obtain information about the publication activity of the journal in March 2015, a counter of readers' references to the materials posted on the site from 2005 to the present which is placed on the journal's website. During 2015 - 2016 years on average there were no more than 100-170 handlings per day. Publication of a number of articles, as well as electronic versions of profile monographs and collections in the public domain, dramatically increased the number of handlings to the journal's website to 500 - 800 per day, and the total number of visits to the site at the end of 2017 was more than 230.000.
The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Medical Radiology and Radiation Safety. 2018. Vol. 63. No. 2. P. 55–61
RADIATION PHYSICS, TECHNOLOGY AND DOSIMETRY
DOI: 10.12737/article_5ac622371650f7.48983677
Field Junction Technique for Helical Tomotherapy-Based Total Body Irradiation
A.A. Loginova1, D.A. Tovmasian2, A.P. Chernyaev2, S.M. Varzar2, D.A. Kobyseva1, A.V. Nechesnyuk1
1. Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. M.V. Lomonosov Moscow State University, Moscow, Russia
A.A. Loginova – Senior Med. Physicist; D.A. Tovmasian – Master’s Degree Student; A.P. Chernyaev – Head of the Dep., Prof., Dr. Sc. Phys.-Math.; S.M. Varzar – Associate Prof., PhD Phys.-Math.; D.A. Kobyzeva – Pediatric Oncologist; A.V. Nechesnyuk – Head of the Radiother. Dep., PhD Med.
Abstract
Purpose: Combination of total body irradiation (TBI) with chemotherapy is widely used technique for conditioning before hematopoietic stem cell transplantation for patient with hematological malignancies worldwide. Total body irradiation for patients with high height has to be divided into two parts: irradiation of upper part of the patient’s body (including head, body and part of legs) and irradiation of lower part of the patient’s body (including leg). There is an area in which the fields overlap each other – the junction area. The aim of this work is the development and verification of simple junction technique that would provide the dose distribution in the junction area from 90 to 125 % of prescribed dose.
Material and methods: Total body irradiation was performed on the Tomotherapy machine using helical geometry of the beam delivery. Distribution of the dose in junction area was investigated. Simple solution was proposed: during the optimization of the radiotherapy plan certain margin should be maintained between upper and lower targets while dose distribution in junction area satisfies the uniformity requirements for the given irradiation geometry. The dimension of the margin was determined experimentally using a CheesePhantom and radiochromic EBT-2 films. The uniformity of dose distribution in the junction area was monitored by in vivo measurements using radiochromic EBT-2 films located on the skin surface of patients.
Results: The dimension of the margin at which the dose in the junction area is within the range of 90 to 125 % of the prescribed dose was determined experimentally and amounted to 5.25 cm. The values of the measured dose were in the range from 97 to 105 %. In total 18 in vivo measurements of the junction area were performed. According to the results of in vivo dosimetry, the values of the doses measured in the junction area were in the range from 93 ± 3 % to 108 ± 4 %.
Conclusion:The developed planning method with the selected plan geometry ensures satisfactory heterogeneity of the dose distribution in the area of field junction between the upper and lower irradiation regions, despite of the existing uncertainty of patient positioning. Results were confirmed by in vivo measurements. The obtained data can be used for total body irradiation of the patients using Helical Tomotherapy.
Key words: radiotherapy, tomotherapy, total body irradiation, junction area
REFERENCES
- Halperin EC, Brady LW, Perez CA, et al. Total body and hemibody irradiation. Perez and Brady’s principles and practice of radiation oncology. New York: Lippincott Williams & Wilkins. 2007:364-77.
- Hui SK, Kapatoes J, Fowler J, Henderson D, et al. Feasibility study of helical tomotherapy for total body or total marrow irradiation. Medical Physics. 2005;32(10):3214-24. DOI: 10.1118/1.2044428.
- Penagaricano JA, Chao M, Van Rhee F, et al. Clinical feasibility of TBI with helical tomotherapy. Bone Marrow Transplant. 2011;46(7):929-35. DOI: 10.1038/bmt.2010.237.
- Gruen A, Ebell W, Wlodarczyk W, et al. Total Body Irradiation (TBI) using Helical Tomotherapy in children and young adults undergoing stem cell transplantation. BioMed Central Radiation Oncology. Apr. 2013;8-92. DOI: 10.1186/1748-717X-8-92.
- Wong JY, Rosenthal J, Liu A, Schultheiss T, et al. Imageguided total-marrow irradiation using helical Tomotherapy in patients with multiple myeloma and acute leukemia undergoing hematopoietic cell transplantation. Int. J. Radiation Oncology Biol. Phys. 2009;73(1):273-9. DOI: 10.1016/j.ijrobp.2008.04.071.
- Kobyzeva DA, Maschyan MA, Willich NA, et al. The first Russian experience of TomoTherapy for total body irradiation in children. Russian Journal of Pediatric Hematology and Oncology. 2016;3(2):64-7. DOI: 10.17650/2311-1267-2016-3-2-64-67. (In Russ.).
- Corvo R, Zeverino M, Vagge S, et al. Helical tomotherapy targeting total bone marrow after total body irradiation for patients with relapsed acute leukemia undergoing an allogeneic stem cell transplant. Radiotherapy and Oncology. 2011;98(3):382-6. DOI: 10.1016/j.radonc.2011.01.016.
- Zeverino M, Agostinelli S, Taccini G, et al. Advances in the implementation of helical tomotherapy-based total marrow irradiation with a novel field junction technique. Medical Dosimetry. 2012;37(3):314-20. DOI: 10.1016/j.meddos.2011.12.001.
- Mancosu P, Navarria P, Castagna L, et al. Plan robustness in field junction region from arcs with differentpatient orientation in total marrow irradiation with VMAT. Physica Medica. 2015;31(7):677-82. DOI: 10.1016/j.ejmp.2015.05.012.
- Sun R, Cuenca X, Itti R, et al. First French experience of total body irradiation using helical Tomotherapy. Cancer. 2017;21(5):365-72. DOI: 10.1016/j.canrad.2017.01.014.
- Langen K, Papanikolaou N, Balog J, et al. QA for helical tomotherapy: Report of the AAPM Task Group 148. Medical Physics. 2010;37(9):4817-53. DOI: 10.1118/1.3462971.
- Tomo Planning Guide 107272A. TomoTherapy® Treatment System; 2012.
- Micke A, Lewis DF, Yu X. Multichannel film dosimetry with nonuniformity correction. Medical Physics. 2011;38(5):2523-34. DOI: 10.1118/1.3576105.
- Aland T, Kairn T, Kenny J. Evaluation of a Gafchromic EBT2 film dosimetry system for radiotherapy quality assurance. Australasian Physical & Engineering Sciences in Medicine. 2011;34(2):251-60. DOI: 10.1007/s13246-011-0072-6.
- Kissick MW, Fenwick J, James JA, et al. The helical tomotherapy thread effect. Medical Physics. 2005;32(5):1414-23. DOI: 10.1118/1.1896453.
For citation: Loginova AA, Tovmasian DA, Chernyaev AP, Varzar SM, Kobyseva DA, Nechesnyuk AV. Junction Technique for Helical Tomotherapy-Based Total Body Irradiation. Medical Radiology and Radiation Safety. 2018;63(2):55-61. Russian. DOI: 10.12737/article_5ac622371650f7.48983677.
PDF (RUS) Full-text article (in Russian)