JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
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The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Medical Radiology and Radiation Safety. 2014. Vol. 59. No. 2. P. 39-46
RADIATION THERAPY
Yu.V. Gumenetskaya, Yu.S. Mardynsky, I.A. Gulidov, O.B. Karyakin
Results of a Comparative Analysis of the Effectiveness of Different Methods of Palliative Radiation Therapy for Bladder Cancer
Medical Radiological Research Center, Kaluga Region, Obninsk. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
ABSTRACT
Purpose: To analyze the results of palliative radiation therapy for bladder cancer and to assess the effects of dose-fractionation regimens on treatment effectiveness.
Material and methods: The immediate and long-term results of palliative radiation therapy in 90 bladder cancer patients who had been treated in the Medical Radiological Research Center within the period from1990 to 2010 were analyzed. Three dose-fractionation regimens were used:
1) Conventional fractionation (CF; single tumor dose 2 Gy, total tumor dose 40–46 Gy; n = 37);
2) Hypofractionation (HF; single tumor dose 3 Gy, total tumor dose 30 Gy, n = 22);
3) Accelerated dynamic dose-fractionation (ADDF; total tumor dose 30 Gy, n = 31).
Results: Palliative radiation therapy could stop and reduce hematuria in 73.1 % and 26.9 % of cases, respectively; alleviate bladder pain syndrome in 75.0 % of cases; achieve objective tumor response to therapy after 6 months and 12 months in 34.4 % and 31.1 % of cases, respectively. Median survival after the palliative treatment was 12.9 ± 1.3 months. After accelerated dynamic fractionation, hematuria was stopped in 91.7 % of cases versus 63.0 % after conventional fractionation (p < 0.05) and 62.5 % of cases after hypofractionation; objective tumor response (6 months after therapy) was achieved in 48.4 % of cases versus 24.3 % after CF (p < 0.05) and 31.8 % of cases after HF. Late bladder complications of grades 1–2 (RTOG/EORTC) were seen in 9.7 % of cases in ADDF group versus 18.2 % in HF group and 18.9 % of cases in CF group (p < 0.2). No complications of grade ≥ 3 occurred. Median survival in CF group was 12.0 ± 1.6 months, in HF group – 12.3 ± 4.4 months, and in ADF group – 14.3 ± 8.5 months.
Conclusion: Radiation therapy is an effective palliative treatment in patients with contraindications for surgical and anti-tumor drug therapy of complications of bladder cancer. Accelerated dynamic dose-fractionation allowed to improve the effectiveness of palliative treatment in bladder cancer patients and to reduce treatment times without complications increasing.
Key words: bladder cancer, palliative radiation therapy, fractionation regimen