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The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
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Medical Radiology and Radiation Safety. 2012. Vol. 57. No. 5. P. 5-10
RADIATION BIOLOGY
K.V. Kotenko1, I.K. Belyaev1, Yu.P. Buzulukov2, А.Yu. Bushmanov1, V.F. Demin2, I.V. Gmoshinski3, E.S. Zhorova1, V.S. Kalistratova1, N.S. Marchenkov2, P.G. Nisimov1, R.V. Raspopov3, V.Yu. Soloviev1
Experimental Research of Zinc Oxide-labeled Nanoparticles Biokinetics in Rats’ Organism after Single Oral Administration by Labeled Atoms Technology
1. Burnasyan Federal Medical Biophysical Center (FMBC) of Federal Medical Biological Agency, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. Russian Research Center Kurchatov Institute, Moscow, Russia; 3. Institute of Nutrition of RAMS, Moscow, Russia
Abstract
Purpose: To make quantitative assessment of zinc oxide-labeled nanoparticles’ biokinetics in laboratory animals’ (rats’) organism after single oral administration.
Material and methods: Suspension of zinc oxide nanoparticles with 30 nmmedian diameter was used as source material. Before the injection nanoparticles were irradiated to thermal neutron beam, so that part of the atoms was activated with formation of radioactive nucleus of 65Zn with half-life of 234.8 days. Four groups of animals were used in the experiment (3 male Wistar rats with average body weight of ~ 170 g in each group). According to number of animals used in the experiment, the suspension of nanoparticles was divided into 12 parts of 0.5 mL each. Animals were sacrificed at hours 4, 24, 72 and 120 after administration; then organs of the sacrificed animals including brain, heart, lung, liver, spleen, pancreas, kidneys, testicle, also remained carcass, blood, excrement and urine were analyzed. Changes of organs’ activity were recorded on low-background gamma-ray spectrometer.
Results: Biokinetic parameters of Vistar rat-males are evaluated after single oral administration of zinc oxide nanoparticles. Maximum content of nanoparticles was observed in 24-72 hours after oral administration. 65Zn mass distribution in rats’ organs at maximum point decreases according to the following sequence: liver®kidneys®spleen ®pancreas®heart®blood®brain.
Conclusion: 1. Technology of producing new type of product - labeled nanoparticles by means of irradiating them with thermal neutrons of nuclear reactor is elaborated. 2. It is proved that there is a possibility to do research of nanoparticles’ biokinetics in the laboratory animal organisms using labeled atoms technology. 3. 65Zn activity records in the rats’ brain (near 0.06 % of administered activity) proves that nanoparticles can mount blood brain barrier.
Key words: nanoparticles, zinc oxide, radioactive label, experiment, rats, biokinetics, blood brain barrier
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For citation: Kotenko KV, Belyaev IK, Buzulukov YuP, Bushmanov АYu, Demin VF, Gmoshinski IV, Zhorova ES, Kalistratova VS, Marchenkov NS, Nisimov PG, Raspopov RV, Soloviev VYu. Experimental Research of Zinc Oxide-labeled Nanoparticles Biokinetics in Rats’ Organism after Single Oral dministration by Labeled Atoms Technology. Medical Radiology and Radiation Safety. 2012;57(5):5-10.
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