JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
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The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
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The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Medical Radiology and Radiation Safety. 2019. Vol. 64. No. 1. P. 15–20
RADIATION BIOLOGY
DOI: 10.12737/article_5c55fb18bed8d6.85887139
I.K. Belyaev
Protection of Spermatogenesis with β-Carothin in Radiation Exposure.
Message 2: Carotenoid Enrichment of Diet with Single Acute External γ-Irradiation
A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
I.K. Belyaev – Head of Lab., Senior Researcher, PhD Biol.
Abstract
Purpose: Experimental evaluation of the efficiency of β-carotene by single acute γ-irradiation of spermatogenesis correction radiation-induced disorders in males (♂) of Wistar rats during prolonged carotenoid enrichment of a diet.
Material and methods: Single external gamma irradiation ♂ was performed at the IGUR facility (137Cs, dose rate 0.029 Gy/s). The carotenoid used up on feeding ♂ in a mixture with cottage cheese for 2 months before irradiation, then – throughout the study period three times a week. During the days that ♂ were in cells with intact ♀ β-carotene was administered ♂ orally by a probe in the form of a suspension in vegetable oil. The damage and effectiveness of protection of spermatogenesis of irradiated ♂ were judged by the state of their reproductive function.
Results: β-carotene in intact ♂ rats reduced the overall, pre- and postimplantation embryonic mortality, respectively, from 29 to 14, from 22 to 9, and from 10 to 5 %. At the stage of mature sperm following irradiation ♂ dose of 3 Gy – total and pre-implantation mortality from 45 to 29, and from 23 to 9 %. After irradiation at a dose of 5 Gy – total, an pre- and postimplantation induced embryonic death, respectively, from 67 to 56, from 23 to 13 % and from 56 to 43 %. At the stage of spermatids after irradiation in dose 1 Gy – pre-implantation mortality from 23 to 9 %; in the dose of 3 Gy – the number of dead embryos in pregnant ♀ from 12 to 3; at a dose of 5 Gy total embryonic mortality from 57 to 49 %. Carotenoid enrichment of a diet of ♂ irradiated at doses of 3 and 5 Gy, has not corrective impact on the state indicators of their reproductive function, evaluated at fertilization of ♀ sperm irradiated at the stage of spermatocyte. At the stage of spermatogonia after irradiation at a dose of 3 Gy β-carotene increased fertility of ♂ 7 to 12 living embryos and reduced the overall, before – induced postimplantation mortality, respectively, with 63 and 43, from 42 to 25 and from 35 to 19 %. No statistically significant effect of β-carotene on the weight loss of the gonads irradiated ♂ was revealed. Compared to short-term regimen, long-term enrichment of a diet of irradiated ♂ β-carotene more effectively reduced embryonic mortality of their offspring.
Conclusions: Correction effects of β-carotene enrichment of the diet in radiation-induced disturbances by single acute external γ-irradiation at doses of 3 and 5 Gy of spermatogenesis in Wistar rats at stages of mature spermatozoa, spermatids and spermatogonia have been established.
Key words: external acute γ-irradiation, spermatogenesis, β-carotene, introduction to the diet, rats
REFERENCES
1. Belyaev IK. Protection of spermatogenesis with β-carotene during radiation exposure. Message 1: Single acute external γ-irradiation. Med. Radiology and Radiation Safety. 2018;63(2):5-14. (Russian).
2. Loskutova ZF. Vivarium. Moscow. 1980. 94 p. (Russian).
3. Vakulova LA, Zhidkova TA, Samokhvalov GI, Khristoforov VL. Method for obtaining beta-carotene. 1995. Patent number 2032667. (Russian).
For citation: Belyaev IK. Protection of Spermatogenesis with β-Carothin in Radiation Exposure. Message 2: Carotenoid Enrichment of Diet with Single Acute External γ-Irradiation. Medical Radiology and Radiation Safety. 2019;64(1):15-20. (Russian).
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