JOURNAL DESCRIPTION
The Medical Radiology and Radiation Safety journal ISSN 1024-6177 was founded in January 1956 (before December 30, 1993 it was entitled Medical Radiology, ISSN 0025-8334). In 2018, the journal received Online ISSN: 2618-9615 and was registered as an electronic online publication in Roskomnadzor on March 29, 2018. It publishes original research articles which cover questions of radiobiology, radiation medicine, radiation safety, radiation therapy, nuclear medicine and scientific reviews. In general the journal has more than 30 headings and it is of interest for specialists working in thefields of medicine¸ radiation biology, epidemiology, medical physics and technology. Since July 01, 2008 the journal has been published by State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The founder from 1956 to the present time is the Ministry of Health of the Russian Federation, and from 2008 to the present time is the Federal Medical Biological Agency.
Members of the editorial board are scientists specializing in the field of radiation biology and medicine, radiation protection, radiation epidemiology, radiation oncology, radiation diagnostics and therapy, nuclear medicine and medical physics. The editorial board consists of academicians (members of the Russian Academy of Science (RAS)), the full member of Academy of Medical Sciences of the Republic of Armenia, corresponding members of the RAS, Doctors of Medicine, professor, candidates and doctors of biological, physical mathematics and engineering sciences. The editorial board is constantly replenished by experts who work in the CIS and foreign countries.
Six issues of the journal are published per year, the volume is 13.5 conventional printed sheets, 88 printer’s sheets, 1.000 copies. The journal has an identical full-text electronic version, which, simultaneously with the printed version and color drawings, is posted on the sites of the Scientific Electronic Library (SEL) and the journal's website. The journal is distributed through the Rospechat Agency under the contract № 7407 of June 16, 2006, through individual buyers and commercial structures. The publication of articles is free.
The journal is included in the List of Russian Reviewed Scientific Journals of the Higher Attestation Commission. Since 2008 the journal has been available on the Internet and indexed in the RISC database which is placed on Web of Science. Since February 2nd, 2018, the journal "Medical Radiology and Radiation Safety" has been indexed in the SCOPUS abstract and citation database.
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The main working language of the journal is Russian, an additional language is English, which is used to write titles of articles, information about authors, annotations, key words, a list of literature.
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The two-year impact factor of RISC, according to data for 2017, was 0.439, taking into account citation from all sources - 0.570, and the five-year impact factor of RISC - 0.352.
Medical Radiology and Radiation Safety. 2019. Vol. 64. No. 4. P. 48–55
DOI: 10.12737/article_5d110f04375033.57581297
B.Ya. Narkevich1,2, S.V. Shiryaev2, I.V. Lagutina1,2, Yu.V. Buydenok2, T.K. Kharatishvili2, N.S. Petrochenko2
Leakage Radiometric Control of Chemical Drugs with Regional Perfusion of Surgical Isolated Limbs
1. Association of Medical Physicists of Russia, Moscow, Russia. E-mail:
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;
2. N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia
B.Ya. Narkevich – President of the AMPR, Leading Researcher, Dr. Sci. Tech., Prof., Academician of International Academy of Engineering;
S.V. Shiryaev – Head of Lab., Dr. Sci. Med., Prof., Member of the European Association of Nuclear Medicine and Molecular Imaging, Member of the American College of Nuclear Medicine and Molecular Imaging, Member of the Society of Nuclear Medicine and Molecular Imaging;
I.V. Lagutina – Medical Physicist;
Yu.V. Buydenok – Perfusiologist, Leading Researcher, Dr. Sci. Med.;
T.K. Kharatishvili – Surgeon, Leading Researcher, Dr. Sci. Med., Prof.;
N.S. Petrochenko – Surgeon, PhD Med.
Abstract
Purpose: Modernization and evaluation of the clinical effectiveness of the technology of continuous radiometric monitoring carried out during high-dose chemotherapy of a surgically isolated limb with tumor foci.
Material and methods: A modernized radiometric control technology for regional limb perfusion is proposed. It is based on in vivo labeling of erythrocytes with 99mTc eluate followed by continuous monitoring of the activity of labeled erythrocytes as a simulator of a chemotherapy drug over the heart region. Its distinctive features are intravenous injection of a pyrfotech slice after giving inhalation anesthesia to ensure a sufficient level of red blood cell chelation, as well as using 99mTc activity less than its minimum significant level, which allows working with an open source of ionizing radiation without violating the requirements of radiation safety regulations.
Results: The developed technology was successfully used with 106 regional perfusion of the upper and lower extremities in patients with melanoma or sarcoma of soft tissues. In 4 cases, according to the results of radiometric control, the intervention of the surgical team was required to reduce the chemical preparation leakage that was occurring.
Conclusion: The technology upgraded by us is characterized by ease of implementation, the ability to take timely measures to prevent or reduce the leakage of a chemotherapy drug from an isolated limb according to the results of continuous in vivo radiometric monitoring of 99mTc-labeled red blood cells over the heart, as well as low radiation load on the patient and staff.
Key words: high-dose chemotherapy, surgically isolated limb, regional perfusion, chemotherapy leaks, radiometric monitoring
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For citation: Narkevich BYa, Shiryaev SV, Lagutina IV, Buydenok YuV, Kharatishvili TK, Petrochenko NS. Leakage Radiometric Control of Chemical Drugs with Regional Perfusion of Surgical Isolated Limbs. Medical Radiology and Radiation Safety. 2019;64(4):48–55. (Russian).
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