Medical Radiology and Radiation Safety. 2016. Vol. 61. No. 6. P. 5-10

RADIATION BIOLOGY

l.H. Poghosyan¹, Z.S. Mkrtchyan¹, M.G. Gazaryants¹, M.G. Malakyan¹, l.E. Abramyan², G.O. Meliksetyan¹, J.I. Akopyan¹

Influence of Electromagnetic Radiation with Frequency of 900 and 1800 MHz on the Activity of Purine Nucleoside Phosphorylase and Alkaline Phosphatase in Some Organs of the Rats

1. Institute of Molecular Biology of NAS RA, Erevan, Armenia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. Erevan State University. Faculty of Radiophysics, Erevan, Armenia

Abstract

Purpose: The sharp increase in the use of mobile phones has put on the agenda the question of the need to study the adverse effects of electromagnetic radiation emitted by mobile phones on the human health. The objective of the paper is to study the effect of low-intensity electromagnetic radiation at frequencies 900 and 1800 MHz (the standards of cellular communication) at levels of purine nucleoside phosphorylase (PNP) activity in the blood serum, liver, and brain of rats, and the alkaline phosphatase (AP) in the serum of rats using two schemes of radiation scheme: single and fractionated (fractional) at different terms of postradiation (the 1st, the 5th, the 10th and the 20th day).

Material and methods: The objects of the study were two enzymes - PNP and AP. PNP is one of the enzymes that characterizes the immune status of the organism. Inhibition of this enzyme leads to the disruption of homeostasis of nucleosides that causes T cell immunodeficiency. AP is involved in the metabolism of phosphoric acid, contributes to phosphorous transport in the body. The materials of the study were white mongrel male rats radiated by a single (two hours continuously) and fractional (for half an hour for four consecutive days) schemes of electromagnetic radiation with frequencies of 900 and 1800 MHz. SPSS package was used for statistical data processing (Statistical Package for Social Science).

Results: Electromagnetic radiation causes oscillatory character of the change in activity of the AP and almost completely inhibits the activity of PNP in the serum. Toxic effect did not affect the activity of the brain and hepatic purine nucleoside phosphorylase. The enzyme in these organs proved resistant properties to this mode of radiation.

Conclusion: It is shown that the electromagnetic radiation with frequencies of 900 and 1800 MHz inhibits PNP in the serum and in the liver and brain enzyme exhibits resistant properties to the action of the radiation, which is apparently due to the absence of toxic effects in these tissues under the influence of the used irradiation modes. The vibrational change of AP activity in serum testify to a considerable sensitivity of serum AP to the effects of the used type of radiation. In subsequent experiments it will be necessary to increase the duration of exposure. In the following experiments it will be necessary to increase the duration of the irradiation.

Key words: purine nucleoside phosphorylase, alkaline phosphatase, activity, electromagnetic radiation, cellular communications

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For citation: Poghosyan LH, Mkrtchyan ZS, Gazaryants MG, Malakyan MG, Abramyan LE, Meliksetyan GO, Akopyan JI. Influence of Electromagnetic Radiation with Frequency of 900 and 1800 MHz on the Activity of Purine Nucleoside Phosphorylase and Alkaline Phosphatase in Some Organs of the Rats. Medical Radiology and Radiation Safety. 2016;61(6):5-10. Russian.

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