Medical Radiology and Radiation Safety. 2016. Vol. 61, No. 5. P. 54-58
DIAGNOSTIC RADIOLDGY
A.D. Ryzhkov1, S.V. Shiryaev1, G.N. Machak2, N.V. Kochergina1, Ya.A. Shchipakhina1, A.S. Krylov1, A.S. Nered1
SPECT/CT in Treatment Monitoring of Bone Metastases of Osteosarcoma with Ultrasound Thermal Ablation Method
1. N.N. Blokhin Russian Cancer Research Center, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. N.N. Priorov Central Research Institute of Traumatology and Orthopaedics, Moscow, Russia
ABSTRACT
Purpose: To demonstrate the diagnostic capabilities to control effects of HIFU treatment in patient with osteosarcoma bone metastases by SPECT-CT method.
Material and methods: SPECT/CT treatment monitoring of the patient with bone metastases of osteosarcoma after ultrasound ablation.
Results: Metastases were detected in the SPECT/CT-pictures. The dynamic observation during the treatment was carried. The effect of the treatment caused by thermoablative manifests in the early stages (observed after 1 month). The effect of the treatment is the lack of accumulation-seeking radiopharmaceutical labeled with 99mTc in the treatment area.
Conclusion: SPECT/CT study is a demonstrative method for early determination of pathological metabolism degree at bone metastases of osteosarcoma after HIFU. SPECT/CT is an effective method of treatment monitoring of bone metastases with use of HIFU therapies.
Key words: SPECT/CT, HIFU, osteosarcoma bone metastases
REFERENSES
- Nazarenko G.I., Khitrova A.N., Krasnova T.V., Bogdanov E.G. Innovatsionnyi metod ul'trazvukovoi ablyatsii opukholei cheloveka (obzor literatury i sobstvennye nablyudeniya). Ul'trazvukovaya i funktsional'naya diagnostika. Moscow: Publ.: OOO "Vidar". 2008. No. 4. P. 53-75 (In Russ.).
- Chen W., Zhu H., Zhang L., Li K. et al. Primary bone malignancy: effective treatment with high-intensity focused ultrasound ablation. Radiology. 2010. Vol. 255. No. 3. P. 967-978. DOI: 10.1148/radiol.10090374.
- Li C., Wu P. Zhang L., Fan W. et al. Osteosarcoma: limb salvaging treatment by ultrasonographically guided high-intensity focused ultrasound. Cancer. Ther. 2009. Vol. 8. No. 12. P. 1102-1108. Epub 2009 Jun 27.
- Li C., Wu P., Zhang L., Fan W. et al. Noninvasive treatment of malignant bone tumors using high-intensity focused ultrasound. Cancer. 2010. Vol. 15. P. 116. No. 16. P. 3934-3942. DOI: 10.1002/cncr.25192.
- Orgera G., Monfardini L., Della Vigna P. et al. High-intensity focused ultrasound (HIFU) in patients with solid malignancies: evaluation of feasibility, local tumour response and clinical results. Radiol Med. 2011. 116. No. 5. P. 734-748. DOI: 10.1007/s11547-011-0634-4. Epub 2011 Feb 1.
- Wu F., Chen WZ., Bai J. et al. Pathologic changes in human malignant carcinoma treated with high intensity focused ultrasound. Ultrasound Med. 2001. Vol. 27. P. 1099-1106.
- Yu W., Tang L., Lin F. et al. High-intensity focused ultrasound: Noninvasive treatment for local unresectable recurrence of osteosarcoma. Surg. 2014. Nov. 14. pii: S0960-7404(14)00075-9. DOI: 10.1016/j.suronc.2014.10.001.
- Lynn J.G., Zwemer R.L., Chick A.J. et al. A new method for the generation and use of focused ultrasound in experimental biology. J. Gen. Physiol. Vol. 26. P. 179-193.
- Clement G.T. Perspectives in clinical uses of high-intensity focused ultrasound. Ultrasonics. 2004. Vol. 42. 1087-1093.
- Mason T.J. A sound investment. Chem Ind. 1998. P. 878-882.
- Wu F., Chen WZ., Bai J. et al. Tumor vessel destruction resulting from high-intensity focused ultrasound in patients with solid malignancies. Ultrasound Med Biol. 2002. Vol. 28. P. 535-542.
- Krzhivitskii P.I., Kanaev S.V., Novikov S.N. OFEKT/KT v diagnostike metastaticheskogo porazheniya skeleta //Voprosy onkologii. 2014. Vol. 60. No. 1. 56-63. (In Russ.).
- Caglar M., Tuncel M., Velipasaoglu Z., Karakaya J. Incremental diagnostic value of SPECT/CT in patients with suspected bone metastases. J. Nucl. Med. 2013. Vol. 54. P. 418-425.
- Keidar Z., Israel O., Krausz Y. SPECT/CT in tumor imaging: technical aspects and clinical applications. Semin. Nucl. Med. 2003. Vol. 33. P. 205-218.
- Utsunomiya D., Shiraishi S., Imuta M. et al. Added value of SPECT. CT fusion in assessing suspected bone metastasis: comparison with scintigraphy alone and nonfused scintigraphy and CT. 2006. Vol. 238. P. 264-271.
- Buck K., Nekolla S., Ziegler S. SPECT/CT. J. Nucl. Med. 2008. 49. Р. 1305-1319. DOI: 10.2967/ jnumed.107.050195.
- Romer W., Nomayr A., Uder M. et al. SPECT-guided CT for evaluating foci of increased bone metabolism classified as indeterminate on SPECT in cancer patients. J. Nucl. Med. 2006. Vol. 47. P. 1102-1106.
For citation: Ryzhkov AD, Shiryaev SV, Machak GN, Kochergina NV, Shchipakhina YaA, Krylov AS, Nered AS. SPECT/CT in Treatment Monitoring of Bone Metastases of Osteosarcoma with Ultrasound Thermal Ablation Method Medical Radiology and Radiation Safety. 2016;61(5):54-8. Russian.