SCIENTIFIC AND INFORMATION-ANALYTICAL MAGAZINE

ISSN 1024-6177 (Print), ISSN 2618-9615 (Online)

Medical Radiology and Radiation Safety. 2016. Vol. 61. No. 2. P. 58-64

RADIATION THERAPY

A.O. Rasulov, D.V. Kuzmichev, V.A. Aliev, Z.Z. Mamedli, S.S. Gordeyev, V.M. Kulushev, A.V. Polinovskiy, I.Sh. Tataev, J.M. Madyarov, A.V. Nazarenko, S.I. Tkachev, V.V. Glebovskaya, N.A. Kozlov

Neoadjuvant Chemoradiotherapy with Consolidation Chemotherapy in Complex Treatment of Locally Advanced Rectal Cancer

N.N. Blokhin Russian Cancer Research Center, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

ABSTRACT

Purpose: To investigate preliminary results of neoadjuvant chemoradiotherapy followed by neoadjuvant chemotherapy in locallyadvanced rectal cancer patients.

Material and methods: Patients aged >18 with histologycally verified MRI-staged low and medium T3 (CRM+)–4N0–2M0 rectal cancer were included. In group A (21 patients) received a preoperative chemoradiation with GENUS 4 Gy 3 times a week, with regional lymph nodes of 32 Gy to the tumor of the rectum 40 Gy with capecitabine 850 mg/m2 bid per os followed by 2 cycles of XELOX. In group B (20 patients) received the same treatment without consolidating chemotherapy. Toxicity, tumor regression, downstaging and postoperative complications were analyzed.

Results: 40 patients completed treatment according to the protocol. The second XELOX chemotherapy was amended in 1 patient in group A due to cardiac toxicity. Grade 3 toxic events were observed in 2 (9.5 %) patients in group A and in 3 (15 %) patients in group B. No grade 4 toxic events were observed. The median follow-up was 10.8 months. No patients experienced disease progression during this period. Postoperative complications were observed in 17.7 % and in 15 % of the patients respectively. Complete response was observed in 9 (42.9 %) patients in group A. Among those, 4 were referred to watchful waiting and 5 were diagnosed with pathological complete response after surgery. In group B complete response was observed in 3 (15 %) patients.

Conclusions: Combined treatment with consolidating chemotherapy represents a promising strategy for rectal.

Key words: locally advanced rectal cancer, the complex treatment of rectal cancer, chemotherapy is consolidating, medical pathomorphosis

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For citation: Rasulov AO, Kuzmichev DV, Aliev VA, Mamedli ZZ, Gordeyev SS, Kulushev VM, Polinovskiy AV, Tataev ISh, Madyarov JM, Nazarenko AV, Tkachev SI, Glebovskaya VV, Kozlov NA. Neoadjuvant Chemoradiotherapy with Consolidation Chemotherapy in Complex Treatment of Locally Advanced Rectal Cancer. Medical Radiology and Radiation Safety. 2016;61(2):58-64. Russian.

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