Medical Radiology and Radiation Safety. 2015. Vol. 60. No. 6. P. 42-47


Mathematical Simulation of Transport Kinetics of Radiopharmaceutical 68Ga-Citrate for PET Imaging of Inflammation

1. A.I. Burnasyan Federal Medical Biophysical Center of FMBA, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; 2. Moscow State Academy of Veterinary Medicine and Biotechnology, Moscow, Russia


Purpose: 68Ga-citrate is 67Ga-citrate analogue and prospective radiopharmaceutical for PET imaging of inflammation and infection. However, some pharmacokinetic hardships such as low blood clearance and long accumulation time in foci (24-72 h) except application possibility of the short-lived gallium-68 (T1/2 = 68 min). Proposed solution of this problem (extra injection of competitive chemical agent; here: Fe-citrate) should be proved quantitatively. Therefore the aim of this study is the creation of a mathematical (compartment) model for the transport kinetics of radiopharmaceutical Ga-citrate with extra injection of stable Fe-citrate.

Material and methods: Ga-citrate and stable Fe-citrate for i. v. injection are the objects of our study. Nonlinear rats’ females (two groups: with/without extra injection of Fe-citrate) with soft tissue inflammation were used. Mathematical simulation of transport kinetics for calculation of pharmacokinetic parameters was created according to the rats’ biodistribution of Ga-citrate.

Results: Extra i. v. injection of Fe-citrate allowed accelerating blood clearance from Ga-citrate, significantly decelerated its liver accumulation and excretion through intestine. Moreover, extra injection of Fe-citrate allowed for the increase of Ga-citrate accumulation and retention in inflammation site.

Conclusion: Mathematical calculations quantitatively confirmed that extra injection of Fe-citrate had a positive impacted on PET imaging of inflammation.

Key words: Ga-citrate, radiopharmaceutical, mathematical simulation, compartment model


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For citation: Lunev AS. Mathematical Simulation of Transport Kinetics of Radiopharmaceutical 68Ga-Citrate for PET Imaging of Inflammation. Medical Radiology and Radiation Safety. 2015;60(6):42-7. Russian.

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