Medical Radiology and Radiation Safety. 2015. Vol. 60. No. 6. P. 48-53


I.A. Znamenskiy, A.K. Kondakov, A.V. Grechko

Positron Emission Tomography with Oxygen-15 in Neurology. Part 1. Basic and Historical Review

Federal State Budgetary Scientific Institution «Hospital for incurable patients - the Scientific and Medical Rehabilitation Center», Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.


Purpose: A historical review of emergent technologies and the development of positron emission tomography with radiopharmaceuticals based on oxygen-15 along with its application in contemporaneity.

Material and methods: The article presents a review of sources selected from international bibliographic databases.

Results: It is shown that positron-emission tomography with radiopharmaceuticals based on oxygen-15 originated from studies of brain perfusion in the early 1960th. With positron emission tomography invented in mid-1970s, these studies lead to deep exploration of pathophysiologic basis of a number of brain diseases, mainly ischemic type diseases. The article presents basic methods of positron-emission tomography with labelled water and gaseous radiopharmaceuticals based on oxygen-15.

Conclusion: Positron-emission tomography with radiopharmaceuticals based on oxygen-15 in contemporaneity is the only one direct validated method of measurement of a number of quantities characterizing the perfusion and functional capacity of the brain. The need to implement a large number of expensive technical measures prevents the wide application of this method.

Key words: positron emission tomography, oxygen-15, perfusion, brain


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For citation: Znamenskiy IA, Kondakov AK, Grechko AV. Positron Emission Tomography with Oxygen-15 in Neurology. Part 1. Basic and Historical Review. Medical Radiology and Radiation Safety. 2015;60(6):48-53. Russian.

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