Medical Radiology and Radiation Safety. 2015. Vol. 60. No. 4. P. 19-26


A.S. Lunev, O.E. Klementyeva, G.E. Kodina

Computational Research of Prognosis Values of Absorbed Doses for Pre-Clinical Safety Evaluation of Radiopharmaceutical 68Ga-Citrate

A.I. Burnasyan Federal Medical Biophysical Center of FMBA, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.


Purpose: 68Ga-citrate is a prospective radiopharmaceutical for PET-imaging of the inflammation. The use of radiopharmaceuticals is assumed with risk of various complications directly related to ionizing radiation. Therefore there is a need of the information on doses conducted to the pathological locus, organs and tissues and the whole organism in the process of the development and pre-clinical study of new radiopharmaceuticals. It is important for the safety assessment of radiopharmaceuticals.

Material and methods: 68Ga-citrate is the object of the study. Nonlinear rats’ females (181.9 ± 16.0 g) with model of soft tissue inflammation conpose the study material. Absorbed and effective doses of 68Ga-citrate were calculated in organs and tissues of rats according to the rats’ body distribution and extrapolated to human body.

Results: OLINDA/EXM 1.0 software was used for the calculation of doses. The highest absorbed doses were recorded as follows: 18.4 mGy in urinary bladder, 11.6 mGy in kidneys and 23.7 mGy in the intestine. Effective dose is 14.9 mSv. Such doses (less than 100 mSv) according ICRP and UNSCEAR publications should not be included in the irradiation damage assessment. Specific absorbed dose of the pathological area (model of aseptic inflammation) is 4.9 ± 4.3 mGy/MBq.

Conclusion: The results of dosimetry evaluation have determined the high safety level of 68Ga-citrate radiopharmaceutical for PET-imaging of the inflammation.

Key words: 68Ga-citrate, OLINDA/EXM 1.0 software, dosimetry


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For citation: Lunev AS, Klementyeva OE, Kodina GE. Computational Research of Prognosis Values of Absorbed Doses for Pre-Clinical Safety Evaluation of Radiopharmaceutical 68Ga-Citrate. Medical Radiology and Radiation Safety. 2015;60(4):19-26. Russian.

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