Medical Radiology and Radiation Safety. 2015. Vol. 60. No. 1. P. 33-38

RADIATION THERAPY

O.P. Trofimova, O.I. Cheban, Z.P. Mikhina, S.V. Medvedev, Ju.I. Prjamikova, N.P. Schipilina, E.V. Timoshkina, E.V. Poddubskaya, A.A. Maklakova, N.V. Vekova, O.C. Zaichenko, A.V. Berdnik, Ju.V. Bikova, M.P. Baranova, I.P. Kovalenko, L.E. Rotobelskaya, S.I. Tkachev

Cardiovascular Complications in Patients with Breast Cancer After Breast-Conserving Treatment

N.N.Blokhin Russian Cancer research center, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

ABSTRACT

Purpose: To evaluate the radiation dose on the heart in patients with left-sided localization of breast cancer receiving radiation therapy after breast-concerving treatment on the free breath and breath-hold at a deep breath.

Material and methods: The study included 113 patients with verified breast cancer T_1-2N_0-1M₀ st. with left-sided localization of tumors who were treated in the N.N. Blokhin Russian Cancer Research Center in 2012-2013. Patients were treated with radical organ resection followed by radiation therapy. Radiation therapy (RT) on the free breath was carried out in 53 patients and on breath-hold at deep breaths in 60 patients. RT - 5 times per week dose 2 Gy per day to a total dose of 50 Gy. Radiation dose distribution in under risk organs was assessed for clinical radiotherapy planning parameters V₂₅ Gy and D_mean to heart.

Results: The data presented show a significant reduction in the volume of the heart, which received a dose of 25 Gy - median performance V₂₅ in RT sync breathing in comparison with the free breathing below the 82 % and the average dose of heart-median performance below the 65 %. The difference is not reliable because of the small number of observations.

Conclusion: The RT with breath holding on deep inhalation in patients with left-sided breast cancer localization reduces an average dose to the heart and the heart volume at the dose of 25 Gy. This allows to expect a further reduction in the incidence of cardio-vascular complications.

Key words: radiotherapy, breast cancer, cardiovascular complications

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For citation: Trofimova OP, Cheban OI, Mikhina ZP, Medvedev SV, Prjamikova JuI, Schipilina NP, Timoshkina EV, Poddubskaya EV, Maklakova AA, Vekova NV, Zaichenko OC, Berdnik AV, Bikova JuV, Baranova MP, Kovalenko IP, Rotobelskaya LE, Tkachev SI. Cardiovascular Complications in Patients with Breast Cancer after Breast-Conserving Treatment. Medical Radiology and Radiation Safety. 2015;60(1):33-8. Russian.

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