Medical Radiology and Radiation Safety. 2015. Vol. 60. No. 1. P. 39-44


G.S. Zhamgaryan, L.I. Musabaeva, V.A. Lisin, Yu.I. Tyukalov

Combined Modality Treatment Including Intraoperative Electron and External Beam Radiation Therapies for Soft Tissue Sarcomas

Tomsk Cancer Research Institute, Tomsk, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.


Purpose: To study the efficiency of the combined modality treatment including intraoperative radiation therapy (IORT) and external radiotherapy for patients with soft tissue sarcomas.

Material and methods: Between 1991 and 2011, a total of 115 patients with soft tissue sarcomas of the trunk and extremities received combined modality IORT and external beam radiation therapy. There were 44 (38 %), male and 71 female (62 %) patients aged from 15 to 75 years (median age 47.6 ± 2.5 years). Primary sarcomas were diagnosed in 79 (69 %) patients and recurrent sarcomas in 36 (31 %). The study included patients with locally advanced stage II-III soft tissue sarcomas and most of them (52 %) had stage III disease.

Results: Acute and late radiation-induced damages were observed only in patients who underwent surgery with 20 Gy IORT. No radiation-induced complications were found in groups I and II. In these groups of patients who received the total radiation dose of 60-65 Gy, the 2-year disease-free survival rates were 76.2 ± 7.5 % and 76.0 ± 11.3 %, respectively.

Key words: combined modality treatment, soft tissue sarcomas, intraoperative radiation therapy, external beam radiotherapy


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For citation: Galstyan IA, Nadejina NM, Levadnaya MG, Aksenenko AV. Ulcer-Cancer of the Skin as an Outcome of Local Radiation Injury. Medical Radiology and Radiation Safety. 2015;60(1):39-44. Russian.

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