Medical Radiology and Radiation Safety. 2018. Vol. 58. No. 4. P. 72–79

RADIATION PHYSICS, TECHNOLOGY AND DOSIMETRY

L.Ia. Klepper

The Approached Estimation of Radiobiological Model Parameters for Larynx Squamous Cell Carcinoma

Central Economic-Mathematical Institute of RAS, Moscow, Russia, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. , This email address is being protected from spambots. You need JavaScript enabled to view it.

Abstract

Purpose: To determine the radiobiological model parameters of a larynx squamous cell carcinoma by a method of Three schedules (TS) and parameters of LQ-function.

Material and methods: TS method for approximate definition of radiobiological parameters of a tumor, number of tumoral cells and their radiosensitivity are described. Results: With the help of TS method the radiobiological parameters of tumor are approximately determined: number of tumor cells N; their radiobiological characteristics g = a + bd, where d – a single dose; also for the first time the method of definition intervals in which parameters LQ of function should lay is considered.

Conclusions: Received results appear to be in good concord with experimental values of radiobiological parameters determined in vitro.

Key words: radiotherapy, mathematical models, larynx squamous cell carcinoma